1921
Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Pemphigus foliaceus is a life threatening skin disease that is associated with autoimmunity to desmoglein, a skin protein involved in the adhesion of keratinocytes. This disease is endemic in certain areas of South America, suggesting the mediation of environmental factors triggering autoimmunity. Among the possible environmental factors, exposure to bites of black flies, in particular has been suggested. In this work, we describe the sialotranscriptome of adult female flies. It reveals the complexity of the salivary potion of this insect, comprised by over 70 distinct genes within over 30 protein families, including several novel families, even when compared with the previously described sialotranscriptome of the autogenous black fly, The uncovering of this sialotranscriptome provides a platform for testing pemphigus patient sera against recombinant salivary proteins from and for the discovery of novel pharmacologically active compounds.

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  • Received : 18 Dec 2009
  • Accepted : 23 Feb 2010

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