Volume 83, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Dengue is an acute emerging infectious disease transmitted by mosquitoes and has become a serious global public health problem. In mainland China, a number of large dengue outbreaks with serious consequences have been reported as early as 1978. In the three decades from 1978 to 2008, a total of 655,324 cases were reported, resulting in 610 deaths. Since the 1990s, dengue epidemics have spread gradually from Guangdong, Hainan, and Guangxi provinces in the southern coastal regions to the relatively northern and western regions including Fujian, Zhejiang, and Yunnan provinces. As the major transmission vectors of dengue viruses, the biological behavior and vectorial capacity of mosquitoes have undergone significant changes in the last two decades in mainland China, most likely the result of urbanization and global climate changes. In this review, we summarize the geographic and temporal distributions, the serotype and genotype distributions of dengue viruses in mainland China, and analyze the current status of surveillance and control of vectors for dengue transmission.


Article metrics loading...

Loading full text...

Full text loading...



  1. Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, , 1998. Dengue and dengue haemorrhagic fever. Lancet 352: 971977.[Crossref]
  2. Yi BT, Zhang ZY, , 2002. Epidemic and control of dengue fever in China. Chin Public Health 18: 11281130.
  3. Luo HM, , 2007. A big challenge for prevention and control of dengue fever in China. South Chin J Prev Med 33: 13.
  4. Mao XH, Zhang ZX, , 2007. The status of epidemic of dengue fever in China. J Pathog Biol 2: 385388.
  5. Han WB, Yang XY, , 2003. Overview of dengue fever in China. Clin J Med Officer 31: 103104.
  6. Guan YQ, Huang ZX, Liao HL, Chen XB, Cai DS, , 2000. Epidemiological analysis of dengue fever in Foshan city, 1978 to 1998. Guangdong Health Prev 26: 710.
  7. Kan B, , 1997. Proposition for prevalence and monitor of dengue fever in China. Chin J Vector Bio Control 8: 152156.
  8. Liang WJ, He JF, Luo HM, Zhou HQ, Yang F, Zheng K, , 2007. Epidemiological analysis of dengue fever in Guangdong province, 2001–2006. South Chin J Prev Med 33: 47.
  9. Luo HM, He J, Zheng K, Li L, Jiang L, , 2002. Analysis on the epidemiologic features of dengue fever in Guangdong province, 1990–2000. Zhonghua Liu Xing Bing Xue Za Zhi 23: 427430.
  10. Liu MH, Hung SY, Pan C, , 2002. Clinical analysis on 1649 cases of dengue fever breakout in Fuzhou city in 1999. Chin J Zoonoses 18: 132133.
  11. Xu G, Dong H, Shi N, Liu S, Zhou A, Cheng Z, Chen G, Liu J, Fang T, Zhang H, Gu C, Tan X, Ye J, Xie S, Cao G, , 2007. An outbreak of dengue virus serotype 1 infection in Cixi, Ningbo, People's Republic of China, 2004, associated with a traveler form Thailand and high dengsity of Aedes albopictus . Am J Trop Med Hyg 76: 11821188.
  12. Qiu FX, Gubler DJ, Liu JC, Chen QQ, , 1993. Dengue in China: a clinical review. Bull World Health Organ 71: 349359.
  13. Yan TS, Hong RS, Shen XN, Weng YW, Cai SK, Xu BH, Li SQ, He JX, Xu LS, Lin YQ, Zheng NX, Lin M, Lin SH, , 2006. Study on the epidemiology and etiologic agent of Dengue fever outbreaks in FUzhou in 2004. Chin J Epidemiol 27: 371374.
  14. Zheng NX, Wang ZH, Lin YQ, Zhang XY, Zheng G, Chen HH, Wu HH, Chen MH, , 2002. Analysis on the result of epidemiological detection of dengue in Fuzhou city from 1999 to 2001. Modern Prev Med 29: 495497.
  15. Fang MY, Zhao WZ, Jiang LH, Chen CH, Liu JW, Bai ZJ, Tian XD, Lin LH, , 2001. Molecular epidemiological study of dengue fever in Guangdong province. Chin J Microbiol Immunol 21: 326329.
  16. Liu JW, Tian XD, Fang MY, Jiang LH, Ren RW, Hong WY, Chen GF, , 2003. Gene sequence of NS1 of three strain dengue 1 virus isolated from Guangdong in China. J Prev Med Chin PLA 21: 64.
  17. Ren RW, Fang MY, Hong WY, Huang BM, Jiang LH, Tian XD, Chen GF, , 2003. Isolation, identification and sequence analyses of dengue virus type 2 strain GD19/2001. Chin J Epidemiol 24: 288290.
  18. Wang L, Wang Y, Jin S, Zunyou Wu ZY, Chin DP, Koplan JP, Wilson ME, , 2008. Emergence and control of infectious diseases in China. Lancet 372: 15981605.[Crossref]
  19. Jetten TH, Focks DA, , 1997. Potential change in the distribution of dengue transmission under climate warming. Am J Trop Med Hyg 57: 285297.
  20. Yi BT, Zhang ZY, Xu DZ, Xi YZ, Fu JG, Lou J, Yuan MH, Liu SQ, Kuang Q, , 2003. Correlation between dengue fever epidemic and climate factors in Guangdong Province. J Fourth Mil Med Univ 24: 143146.
  21. Brower V, Report, 2001. Vector-borne diseases and global warming: are both on an upward swing. Eur Mol Biol Organ 21:755757.
  22. Yi BT, Zhang ZY, Xu DZ, , 2003. Study on influence of climate factors on dengue vector Aedes density. Chin J Publ Health 19: 129131.
  23. Reiter P, , 2008. Climate change and mosquito-borne disease: knowing the horse before hitching the cart. Rev Sci Tech 27: 383398.
  24. Benitez MA, , 2009. Climate change could affect mosquito-borne diseases in Asia. Lancet 373: 1070.[Crossref]
  25. Shao Y, Jiang LF, Ye CY, , 2000. Molecular epidemiology of dengue fever. Chin J Microecol 12: 365368.
  26. Rico-Hesse R, , 1990. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174: 479492.[Crossref]
  27. Rico-Hesse R, Lisa M, Aannda N, Vaughn DW, Kalayanarooj S, Green S, Rothman AL, Ennis FA, , 1998. Molecular evolution of dengue type 2 virus in Thailand. Am J Trop Med Hyg 58: 96101.
  28. Lanciotti R, Lewis JG, Gubler JD, Trent DW, , 1994. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol 75: 6575.[Crossref]
  29. Lanciotti R, Gubler D, Trent DW, , 1997. Molecular evolution and phylogeny of dengue-4 viruses. J Gen Virol 78: 22792286.[Crossref]
  30. Tian XD, Liu JW, Fang MY, Jiang LH, Ren RW, Hong WY, Cheng GF, , 2005. Analysis of the E gene sequences of three dengue virus type 1isolates in Guangdong province. J First Mil Med Univ 25: 5457.
  31. Yao HJ, Liu JW, Fang MY, Zhao WZ, Liao YH, Lin LH, Jiang LH, Wu SM, Lei LB, , 2005. Sequence analysis of NA2a-NS2b of dengue 4 viruses in Guangdoang province. J Prev Med Chin PLA 23: 2325.
  32. Wang ZG, Tang Q, Zhao XQ, , 2000. Preliminary study on variation of Guangdong dengue-1 virus strains. Chin J Microbiol Immunol 20: 160163.
  33. Zhang JL, Rui X, Wan YJ, Peng T, An J, Zhang FC, Tang XP, , 2005. Identification and phylogenetic analysis of virulence of dengue-1 virus isolated from strains prevalent in Guangzhou in 2002. Acta Acad Med Mil Tertiae 27: 282286.
  34. Lu YC, Jiang ZY, Chen WS, Ren RW, Fang MY, Wang SZ, Cheng GF, Tian XD, Liu JW, Yin ZB, , 2004. Isolation and sequence analysis of dengue virus type 1 from suspected dengue virus infected patients in Guangzhou in 2003. J Trop Med 4: 666669.
  35. Han JF, Yu M, Chen SP, Jiang T, Qin CF, Qin ED, , 2008. Genomic characteristics and phylogenetic analysis of dengue virus type 1 isolated from Guangzhou in 2006. Med J Chin PLA 33: 10551058.
  36. Weng YW, Chen D, Zhang ZS, Zhao ZY, Xie JF, Shen XN, Yan TS, , 2006. Complete genome sequencing and phylogenetic analysis of a Dengue virus type I strain isolated in Fujian province. Chin J Zoonoses 22: 10131016.
  37. Zhou JM, Jiang LF, Gao Y, Xue YH, Fang DY, , 2003. Gene sequencing and analysis of the envelope protein of dengue 2 virus isolated in Hainan China. Chin J Microbiol Immunol 23: 304306.
  38. Fang MY, Ren RW, Hong WY, Liu JW, Jiang LH, Tian XD, Lin LH, , 2003. Sequencing and structural analysis of structural gene of three dengue virus type 2 isolated from Guangdong province. Chin J Microbiol Immunol 23: 300303.
  39. Li JJ, Ren RW, Ma AD, Xu XL, Shen M, Jiang ZJ, , 2006. Sequencing and analysis of the structural gene of dengue virus type 2 strain GD06 /93 isolated from Foshan, Guangdong province. J Trop Med 8: 877880.
  40. Geng LQ, Qin ED, Zhao W, Hu ZJ, Yuan XT, Yu M, Li XY, Yang PY, , 2001. Genomic sequence determination of a new dengue 2 virus Fujian strain. Chin J Microbiol Immunol 21: 330333.
  41. Liu ZW, Yu YX, Jia LL, Dong GM, Wang ZW, , 2007. Sequence determination and phylogenetic analysis of two dengue virus type 4 strains isolated in the first outbreak of dengue fever after the foundation of the People's Republic of China. Chin J Zoonoses 23: 678683.
  42. An JY, Yan G, Zhang XW, Yan BS, , 2003. Aedes albopictus: the important transmission vector. Med Ani Prev 17: 449452.
  43. Su AF, Pei ZC, Fu JC, Li JG, Feng F, Zhu Q, Huang SP, , 2005. Analysis of distribution and population density changes of Aedes egypti the transmission vector of dengue fever in Haikou city. China Trop Med 5: 13941395.
  44. Lin LH, Chen WJ, Ma YH, Bai ZJ, Yang JQ, Fang MY, , 2000. Analysis on relationship between characteristic of bleeding in house and dengue epidemic. Chin Public Health 16: 610.
  45. Song XL, Huang JL, Zheng XY, Wu Y, , 2005. Advancement study on dengue virus transmission efficacy with adult mosquito. J Trop Med 5: 251253.
  46. Tang SY, Li GA, Zhang QE, , 1987. Study on transmission efficacy spreading dengue virus by several mosquito in China. Bull Acad Mil Med Sci 30: 458462.
  47. Zhou GZ, Zhao TY, Guo XX, Zhu LH, Xue J, , 2004. Study among different strains of Aedes aegypti in susceptibility for oral infection with DEN-2 virus. Chin J Vector Bio Control 15: 99101.
  48. Zhang S, He GM, , 1989. Different geographical strains Aedes albopictus susceptibility to dengue virus in China. Zhonghua Liu Xing Bing Za Zhi 10: 348351.
  49. Zhou GZ, Zhao TY, Xue J, , 2003. The impact of the media mosquito susceptibility to dengue virus research. Chin J Vector Bio & Control 14: 237239.
  50. Zhang S, He GM, , 1989. Observation of barrier Aedes mosquito infected with dengue virus in vivo . Chin J Zoonoses 5: 3536.
  51. Xi GL, , 2000. Study on the influence of meteorological factors upon density of mosquito. Chin J Vector Bio Control 11: 2123.
  52. Lin LH, Fang MY, Chen CH, Peng YF, , 2000. Study on vectorial capacity spreading dengue virus by Aedes albopictus . Chin J Vector Bio Control 11: 173176.
  53. Zhao X, Zuo L, Shu LP, Wei LH, , 2006. Study on vertical transmission with dengue virus in Aedes albopietus . Chin J Publ Health 22: 11851187.
  54. Fang MY, Chen CH, Li JQ, Li RB, Wen WD, Peng YF, Lin LH, Chen Z, Tian XD, Jiang LH, Bai ZJ, Chen WJ, , 1999. Epidemiological surveillance of dengue fever in Guangdong province. Chin Public Health 15: 990991.
  55. Duan JH, Lin LF, Cai SW, Lu WC, Zheng K, Yi JR, , 2006. Detection of dengue virus from Aedes albopitus by TaqMan MGB real-time polymerase chain reaction. Chin J Vector Bio Control 17: 8689.
  56. Chow VT, Chan YC, Yong R, Lee KM, Lim LK, Chung YK, Lam-Phua SG, Tan BT, , 1998. Monitoring of dengue viruses in field-caught Aedes aegypti and Aedes albopictus mosquitoes by a type-specific polymerase chain reaction and cycle sequencing. Am J Trop Med Hyg 58: 578586.
  57. Kow CY, Koon LL, Yin PF, , 2001. Detection of dengue viruses in field caught male Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Singapore by type-specific PCR. J Med Entomol 38: 475479.[Crossref]
  58. Xie ZS, Fu JC, , 2007. Results of monitoring and control of transmission vectors of dengue fever in Haikou City in 2005–2006. China Trop Med 7: 14161417.
  59. Tan Y, Feng XY, Jiang JH, , 2004. Analysis on the dengue vector surveillance results during 2002–2003 in Guangxi. Chin J Hyg Insecticides Equipment 10: 154156.
  60. Lin LF, Lu WC, Cai SW, Duan JH, Yi JR, Deng F, Chen Q, Chen XG, , 2005. The design and efficacy observation of new mosq-ovitrap for monitoring of vector of dengue fever. Chin J Vector Biol Control 16: 2628.
  61. Yu DX, Ren XQ, Zhou W, Liao YX, Chen Q, Yu SY, , 2008. Efficacy observation of mosq-ovitrap for monitoring Aedes albopictus in field. J Trop Med 8: 309312.
  62. Xu RQ, Jiang LY, Ren WJ, Hong M, Leng PE, Wang SZ, , 2006. Efficacy observation of mosq-ovitrap for monitoring Aedes albopictus in field. Chin J Hyg Insecticides Equipment 12: 345348.
  63. Lin LF, Cai SW, Duan JH, Zhou H, Lu WC, Feng Q, Chen Q, , 2005. Application of mosq-ovitrap on vector surveillance during dengue fever outbreak. Chin J Publ Health 21: 14591461.
  64. You JR, Zheng SH, Li JQ, Ye ZY, Li RB, Lin LF, Huang Y, Lai PH, , 2008. Study on new method of mosq-ovitrap for monitoring of vector of dengue fever. Chin J Vector Bio Control 19: 368369.
  65. Luo HM, , 2003. Manual for Prevention and Control of Dengue Fever. Beijin: Chinese Standard Publishing, 16.
  66. Zeng TM, , 1997. Mosquito biological control and its role in integrated control. Chin J Hygienic Insecticides Equipment 3: 57.
  67. Wang HW, Wang XG, , 2000. Population surveillance and prevention for dengue fever vector–Aedes mosquito. Chin Med Ani Prev 16: 389391.
  68. Pan American Health Organization, 1994. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. Washington, DC: PAHO, 320, 49–58, 69–70.
  69. Gubler D, , 1989. Aedes aegypti and Aedes aegypti-borne disease control in the 1990s: top down or bottom up. Am J Trop Med Hyg 40: 571578.
  70. Newton E, Reiter P, , 1992. A model of the transmission of dengue fever with an evaluation of the impact of ultra-low volume (ULV) insecticide applications on dengue epidemics. Am J Trop Med Hyg 47: 709720.
  71. Yi BT, Xu DZ, Zhang ZY, Zhang B, Xi YZ, Fu JG, Luo J, Yuan MH, Liu SQ, Kuang Q, , 2003. Study on the distribution of dengue fever and vector in Guangdong province combined application of SRS/GIS/ PCA. Chin J Dis Control Prev 7: 509514.
  72. Yi BT, Xu DZ, Zhang ZY, Zhang B, Xi YZ, Fu JG, Luo J, Yuan MH, Liu SQ, , 2004. Development and application of geographic information system of Aedes vector in Chaozhou city Guangdong province. Zhonghua Liu Xing Bing Xue Za Zhi 25: 134137.
  73. Yi BT, Xu DZ, Zhang ZY, Zhang B, Xi YZ, Fu JG, Luo J, Yuan MH, Liu SQ, , 2003. Study on the relationship between NDVI of NOAA-AVHRR image and the Aedes density in Guangdong Province. J Fourth Mil Med Univ 24: 17201724.
  74. Su M, Chang N, , 1994. Framework for application of GTS on the monitoring of dengue vectors: Kaohsiung. Med Sci 10: 94101.
  75. Nene V, Wortman JR, Lawson D, Haas B, Kodira C, Tu ZJ, Loftus B, Megy K, Grabherr M, Ren Q, Zdobnov EM, Lobo NF, Campbell KS, Brown SE, Bonaldo MF, Zhu J, Sinkins SP, Hogenkamp DG, Amedeo P, Arensburger P, Atkinson PW, Bidwell S, Biedler J, Birney E, Bruggner RV, Costas J, Coy MR, Crabtree J, Crawford M, Debruyn B, Decaprio D, Eiglmeier K, Eisenstadt E, El-Dorry H, Gelbart WM, Gomes SL, Hammond M, Hannick LI, Hogan JR, Holmes MH, Jaffe D, Johnston JS, Kennedy RC, Koo H, Kravitz S, Kriventseva EV, Kulp D, Labutti K, Lee E, Li S, Lovin DD, Mao C, Mauceli E, Menck CF, Miller JR, Montgomery P, Mori A, Nascimento AL, Naveira HF, Nusbaum C, O'leary S, Orvis J, Pertea M, Quesneville H, Reidenbach KR, Rogers YH, Roth CW, Schneider JR, Schatz M, Shumway M, Stanke M, Stinson EO, Tubio JM, Vanzee JP, Verjovski-Almeida S, Werner D, White O, Wyder S, Zeng Q, Zhao Q, Zhao Y, Hill CA, Raikhel AS, Soares MB, Knudson DL, Lee NH, Galagan J, Salzberg SL, Paulsen IT, Dimopoulos G, Collins FH, Birren B, Fraser-Liggett CM, Severson DW, , 2007. Genome sequence of Aedes aegypti, a major arbovirus vector. Science 316: 17181722.[Crossref]
  76. Adelman ZN, Sanchez-Vargas I, Travanty EA, Carlson JO, Beaty BJ, Blair CD, Olson KE, , 2002. RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome. J Virol 76: 1292512933.[Crossref]
  77. Franz AW, Sanchez-Vargas I, Adelman ZN, Blair CD, Beaty BJ, James AA, , 2006. Engineering RNA interference-based resistance to dengue virus type-2 in genetically-modified Aedes aegypti . Proc Natl Acad Sci USA 103: 41984203.[Crossref]

Data & Media loading...

  • Received : 14 Dec 2009
  • Accepted : 06 Mar 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error