1921
Volume 82, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Hepatitis E is a worldwide public health problem, especially in areas with poor sanitation. This study examines the potential hepatitis E virus (HEV) animal reservoirs and the current status of HEV infection among animals and humans in an endemic area of Xinjiang, China. One thousand five hundred twenty-one serum samples from 12 different animal species and 296 sera from humans were detected for anti-HEV with an in-house enzyme immunoassay, and partial HEV RNA was amplified with a reverse transcription–nested polymerase chain reaction (RT-nPCR). All these distinct animal species, except jerboa and hoptoad, were positive for anti-HEV. However, HEV RNA was only amplified from pigs and a sporadic hepatitis E case in humans. The human HEV strain (CHN-XJ-HE29) shared 100% nucleotide identity with the swine HEV strain (CHN-XJ-SW50), both of which were collected from the same district; this indicates the possibility of HEV transmission from swine to humans in an endemic area.

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2010-05-01
2017-09-19
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References

  1. Dalton HR, Bendall R, Ijaz S, Banks M, , 2008. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis 8: 698709.[Crossref]
  2. Mushahwar IK, , 2008. Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention. J Med Virol 80: 646658.[Crossref]
  3. Meng XJ, , 2009. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet Microbiol 140: 256265.[Crossref]
  4. Aye TT, Uchida T, Ma XZ, Iida F, Shikata T, Zhuang H, Win KM, , 1992. Complete nucleotide sequence of a hepatitis E virus isolated from the Xinjiang epidemic (1986–1988) of China. Nucleic Acids Res 20: 3512.[Crossref]
  5. Zhuang H, Li K, Zhu W, , 2000. Partial nucleotide sequences of hepatitis E viruses isolated from patients in 14 cities of China. Zhonghua Yixue Zazhi 80: 893896.
  6. Li RC, Ge SX, Li YP, Zheng YJ, Nong Y, Guo QS, Zhang J, Ng MH, Xia NS, , 2006. Seroprevalence of hepatitis E virus infection, rural southern People's Republic of China. Emerg Infect Dis 12: 16821688.[Crossref]
  7. Zheng Y, Ge S, Zhang J, Guo Q, Ng MH, Wang F, Xia N, Jiang Q, , 2006. Swine as a principal reservoir of hepatitis E virus that infects humans in eastern China. J Infect Dis 193: 16431649.[Crossref]
  8. Ning H, Yu S, Zhu Y, Dong S, Yu R, Shen S, Niu Z, Li Z, , 2008. Genotype 3 hepatitis E has been widespread in pig farms of Shanghai suburbs. Vet Microbiol 126: 257263.[Crossref]
  9. Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, Haynes JS, Thacker BJ, Emerson SU, , 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci USA 94: 98609865.[Crossref]
  10. Nishizawa T, Takahashi M, Mizuo H, Miyajima H, Gotanda Y, Okamoto H, , 2003. Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99% identity over the entire genome. J Gen Virol 84: 12451251.[Crossref]
  11. Ji Y, Zhu Y, Liang J, Wei X, Yang X, Wang L, Li L, Chang Y, Tang R, Zhuang H, , 2008. Swine hepatitis E virus in rural southern China: genetic characterization and experimental infection in rhesus monkeys (Macaca mulatta). J Gastroenterol 43: 565570.[Crossref]
  12. Li L, Zhu Y, Fu H, Wei X, Wang L, Liang J, Ji Y, Tang R, Zhuang H, , 2009. Full-genome nucleotide sequence and analysis of a Chinese swine hepatitis E virus isolate of genotype 4 identified in the Guangxi Zhuang autonomous region: evidence of zoonotic risk from swine to human in South China. Liver Int 29: 12301240.[Crossref]
  13. Shukla P, Chauhan UK, Naik S, Anderson D, Aggarwal R, , 2007. Hepatitis E virus infection among animals in northern India: an unlikely source of human disease. J Viral Hepat 14: 310317.[Crossref]
  14. Arankalle VA, Chobe LP, Joshi MV, Chadha MS, Kundu B, Walimbe AM, , 2002. Human and swine hepatitis E viruses from western India belong to different genotypes. J Hepatol 36: 417425.[Crossref]
  15. Wang YC, Zhang HY, Xia NS, Peng G, Lan HY, Zhuang H, Zhu YH, Li SW, Tian KG, Gu WJ, Lin JX, Wu X, Li HM, Harrison TJ, , 2002. Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol 67: 516521.[Crossref]
  16. Okamoto H, Takahashi M, Nishizawa T, Usui R, Kobayashi E, , 2004. Presence of antibodies to hepatitis E virus in Japanese pet cats. Infection 32: 5758.[Crossref]
  17. Sonoda H, Abe M, Sugimoto T, Sato Y, Bando M, Fukui E, Mizuo H, Takahashi M, Nishizawa T, Okamoto H, , 2004. Prevalence of hepatitis E virus (HEV) Infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan. J Clin Microbiol 42: 53715374.[Crossref]
  18. Okamoto H, , 2007. Genetic variability and evolution of hepatitis E virus. Virus Res 127: 216228.[Crossref]
  19. Nakamura M, Takahashi K, Taira K, Taira M, Ohno A, Sakugawa H, Arai M, Mishiro S, , 2006. Hepatitis E virus infection in wild mongooses of Okinawa, Japan: demonstration of anti-HEV antibodies and a full-genome nucleotide sequence. Hepatol Res 34: 137140.[Crossref]
  20. Huang RT, Li DR, Wei J, Huang XR, Yuan XT, Tian X, , 1992. Isolation and identification of hepatitis E virus in Xinjiang, China. J Gen Virol 73: 11431148.[Crossref]
  21. Liang JR, Wei X-F, Xue C, Ji Y-L, Zhu Y-H, , 2007. Genotype and subgenotype of swine HEV. Zhonghua Weishengwuxue He Mianyixue Zazhi 27: 747750.
  22. Xun MA, Cheng-ping LU, , 2005. Analysis of the complete genome of a strain swCH25 of swine hepatitis E virus isolated from Xinjiang. Zhongguo Nongye Kexue 38: 16691774.
  23. Zhang W, Shen Q, Mou J, Gong G, Yang Z, Cui L, Zhu J, Ju G, Hua X, , 2008. Hepatitis E virus infection among domestic animals in eastern China. Zoonoses Public Health 55: 291298.[Crossref]
  24. Saad MD, Hussein HA, Bashandy MM, Kamel HH, Earhart KC, Fryauff DJ, Younan M, Mohamed AH, , 2007. Hepatitis E virus infection in work horses in Egypt. Infect Genet Evol 7: 368373.[Crossref]
  25. Usmanov RK, Balaian MS, Dvoinikova OV, Alymbaeva DB, Zamiatina NA, Kazachkov IA, Belov VI, , 1994. An experimental infection in lambs by the hepatitis E virus. Vopr Virusol 39: 165168.
  26. Hirano M, Ding X, Li TC, Takeda N, Kawabata H, Koizumi N, Kadosaka T, Goto I, Masuzawa T, Nakamura M, Taira K, Kuroki T, Tanikawa T, Watanabe H, Abe K, , 2003. Evidence for widespread infection of hepatitis E virus among wild rats in Japan. Hepatol Res 27: 15.[Crossref]
  27. Maneerat Y, Clayson ET, Myint KS, Young GD, Innis BL, , 1996. Experimental infection of the laboratory rat with the hepatitis E virus. J Med Virol 48: 121128.[Crossref]
  28. Li TC, Suzaki Y, Ami Y, Tsunemitsu H, Miyamura T, Takeda N, , 2008. Mice are not susceptible to hepatitis E virus infection. J Vet Med Sci 70: 13591362.[Crossref]
  29. Johne R, Plenge-Bonig A, Hess M, Ulrich RG, Reetz J, Schielke A, , 2010. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol 91: 750758.[Crossref]
  30. Lu L, Li C, Hagedorn CH, , 2006. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev Med Virol 16: 536.[Crossref]
  31. Dong C, Dai X, Shao JS, Hu K, Meng JH, , 2007. Identification of genetic diversity of hepatitis E virus (HEV) and determination of the seroprevalence of HEV in eastern China. Arch Virol 152: 739746.[Crossref]
  32. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, Emerson SU, Purcell RH, , 2002. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol 40: 117122.[Crossref]
  33. Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, Sato S, Kato T, Nishimori H, Tsuji K, Maguchi H, Yoshida J, Maekubo H, Mishiro S, Ikeda H, , 2008. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion 48: 13681375.[Crossref]
  34. Kulkarni MA, Arankalle VA, , 2008. The detection and characterization of hepatitis E virus in pig livers from retail markets of India. J Med Virol 80: 13871390.[Crossref]
  35. Zhang CX, Li W, Xiang Y, Arsya, 2003. Investigation on the distribution of HEV in different nationalities and animals from Urumqi. Difangbing Tongbao 18: 3335.
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  • Received : 19 Nov 2009
  • Accepted : 11 Jan 2010

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