1921
Volume 83, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Immunity to saliva of protects against infection as determined by co-inoculation of parasites with salivary gland homogenates (SGHs) of this vector. These results were obtained with long-term colonized female . We investigated the effect of pre-immunization with SGH of long-term colonized against infection co-inoculated with SGH of wild-caught . Our results showed that pre-exposure to SGH of long-term, colonized do not confer protection against infection with co-inoculated with SGH of wild-caught . These preliminary results strongly suggest that the effectiveness of a vector saliva-based vaccine derived from colonized sand fly populations may be affected by inconsistent immune response after natural exposure.

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2010-09-01
2017-11-21
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References

  1. Belkaid Y, Kamhawi S, Modi G, Valenzuela J, Noben-Trauth N, Rowton E, Ribeiro J, Sacks DL, , 1998. Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva pre-exposure on the long-term outcome of Leismania major infection in the mouse ear dermis. J Exp Med 188: 19411953.[Crossref]
  2. Kamhawi S, Belkaid Y, Modi G, Rowton E, Sacks D, , 2000. Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies. Science 290: 13511354.[Crossref]
  3. Valenzuela J, Belkaid Y, Garfiela MK, Mendez S, Kamhawi S, Rowton E, Sacks D, Ribeiro JMC, , 2001. Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. J Exp Med 194: 331342.[Crossref]
  4. Handman E, , 2001. Protective saliva: a novel approach to a Leishmania vaccine. Trends Parasitol 17: 513514.[Crossref]
  5. Ben Hadj Ahmed S, Chelbi I, Kaabi B, Cherni S, Derbali M, Zhioua E, , 2010. Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice. J Med Entomol 47: 7479.[Crossref]
  6. Laurenti MD, Silveira VM, Secundino NF, Corbett CE, Pimenta PP, , 2009. Saliva of laboratory-reared Lutzomyia longipalpis exacerbates Leishmania (leishmania) amazonensis infection more potently than saliva of wild-caught Lutzomyia longipalpis . Parasitol Int 58: 220226.[Crossref]
  7. Laurenti MD, da Matta VL, Pernichelli T, Secundino NF, Pinto LC, Corbett CE, Pimenta PP, , 2009. Effects of saliva gland homogenate from wild-caught and laboratory-reared Lutzomyia longipalpis on the evolution and immunomodulation of Leishmania (leishmania) amazonensis infection. Scand J Immunol 70: 389395.[Crossref]
  8. Chelbi I, Zhioua E, , 2007. Biology of Phlebotomus papatasi (Diptera: Psychodidae) in the laboratory. J Med Entomol 44: 597600.[Crossref]
  9. Chelbi I, Derbali M, AL-Ahmadi Z, Zaafouri B, El Fahem A, Zhioua E, , 2007. Phenology of Phlebotomus papatasi (Diptera: Psychodidae) relative to the seasonal prevalence of zoonotic cutaneous leishmaniasis in central Tunisia. J Med Entomol 44: 385388.[Crossref]
  10. Laird NM, Ware JH, , 1982. Random-effect models for longitudinal data. Biometrics 38: 963974.[Crossref]
  11. Bauer DF, , 1972. Constructing confidence sets using rank statistics. J Am Stat Assoc 67: 687690.[Crossref]
  12. Holm S, , 1979. A simple sequentially rejective multiple test procedure. Scand J Stat 6: 6570.
  13. Elnaiem DEA, Menesses C, Slotman M, Lanzaro GC, , 2005. Genetic variation in the sand fly salivary protein, SP-15, a potential vaccine candidate against Leishmania major . Insect Mol Biol 14: 145150.[Crossref]
  14. Lanzaro GC, Lopes AHCS, Riberiro JMC, Shoemaker CB, Warburg A, Soares M, Titus RG, , 1999. Variation in the salivary peptide, maxadilan from species in the Lutzomyia longipalpis complex. Insect Mol Biol 8: 267275.[Crossref]
  15. Milleron RS, Mutebi JP, Valle S, Montoya A, Yin H, Soong L, Lanzaro GC, , 2004. Antigenic diversity in maxadilan, a salivary protein from the sand fly vector of American visceral leishmaniasis. Am J Trop Med 70: 278293.
  16. Morris RV, Shoemaker CB, David JR, Lanzaro GC, Titus R, , 2001. Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection. J Immunol 167: 52265230.[Crossref]
  17. Oliveira F, Lawyer PG, Kamhawi S, Valenzuela JG, , 2008. Immunity to distinct sand fly salivary proteins primes the anti-Leishmania immune response towards protection or exacerbation of disease. PLOS Neg Trop Dis 2: e226.[Crossref]
  18. Gomes R, Teixeira C, Teixeira MJ, Olivera F, Menezes MJ, Silva C, Miranda JC, Kamhawi S, Valenzuela J, Brodskyn CI, , 2008. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proc Natl Acad Sci USA 105: 78457850.[Crossref]
  19. Lorenz L, Beaty BJ, Aitken THG, Wallis GP, Tabachnik WJ, , 1984. The effect of colonization upon Aedes aegypti susceptibility to oral infection with yellow fever virus. Am J Trop Med Hyg 33: 690694.
  20. Kassem HA, Fryauff DJ, Shehata MG, Sawaf BM, , 1993. Enzyme polymorphism and genetic variability of one colonized and several field populations of Phlebotomus papatasi (Diptera: Psychodidae). J Med Entomol 30: 407413.[Crossref]
  21. Mukhopadhyay J, Rangel E, Ghosh K, Munstermann LE, , 1997. Patterns of genetic variability in colonized strains of Lutzomyia longipalpis (Diptera: Psychodidae) and its consequences. Am J Trop Med Hyg 57: 216221.
  22. Lanzaro GC, Warburg A, , 1995. Genetic variability in phlebotomine sand flies: possible implication for leishmaniasis epidemiology. Parasitol Today 4: 151154.[Crossref]
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  • Received : 17 Nov 2009
  • Accepted : 23 Apr 2010

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