Volume 83, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The state of Veracruz, Mexico, is a well-recognized endemic region for Chagas disease, but the geographic distribution of the disease and its magnitude are still poorly documented. We evaluated the seroprevalence of infection in the sanitary jurisdictions of Cordoba and Cosamaloapan in central Veracruz. A total of 654 serum samples from 19 rural localities were tested by using four tests: two enzyme-linked immunosorbent assays, an indirect immunofluorescent, and Western blotting. Overall, 110 (16.8%) of 654 samples were positive for . by ≥ 2 tests (95% confidence interval = 14.2–19.9%). The municipality of Tezonapa in the jurisdiction of Cordoba was identified as a potential hyperendemic region with seroprevalence rates ≤ 45% in young children. No cases were detected in the jurisdiction of Cosamaloapan. Further studies should help clarify transmission dynamics in Tezonapa. The magnitude of infection rate in this region calls for the urgent implementation of extensive epidemiologic surveillance and control programs.


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  1. World Health Organization, 2007. Reporte Sobre la Enfermedad de Chagas. 17–20 de Abril de 2005, Actualizado en Julio de 2007, Buenos Aires, Argentina. Geneva: World Health Organization. [Google Scholar]
  2. Dumonteil E, , 1999. Update on Chagas' disease in Mexico. Salud Publica Mex 41: 322327.[Crossref] [Google Scholar]
  3. Cruz-Reyes A, Pickering-Lopez JM, , 2006. Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years: a review. Mem Inst Oswaldo Cruz 101: 345354.[Crossref] [Google Scholar]
  4. Salazar PM, Rojas G, Bucio M, Cabrera M, Garcia G, Ruiz A, Guevara Y, Tapia R, , 2007. Seroprevalencia de anticuerpos contra Trypanosoma cruzi y su asociacion con factores de riesgo en menores de 18 anos de Veracruz, Mexico. Rev Panam Salud Publica 22: 7582.[Crossref] [Google Scholar]
  5. Velasco Castrejon O, Valdespino JL, Tapia Conyer R, Salvatierra B, Guzman Bracho C, Magos C, Llausas A, Gutierrez G, Sepulveda J, , 1992. Seroepidemiologia de la enfermedad de Chagas en Mexico. Salud Publica Mex 34: 186196.[Crossref] [Google Scholar]
  6. Ramos-Ligonio A, Ramirez-Sanchez ME, Gonzalez-Hernandez JC, Rosales-Encina JL, Lopez-Monteon A, , 2006. Prevalencia de anticuerpos contra Trypanosoma cruzi en donadores de sanger del IMSS, Orizaba, Veracruz, Mexico. Salud Publica Mex 48: 1321.[Crossref] [Google Scholar]
  7. Olivera-Mar A, Hernandez-Vicencio C, Camacho-Marie M, Hernandez-Becerril N, Monteon-Padilla VM, Vallejo M, Reyes PA, , 2006. Chronic chagasic cardiomyopathy at the Hospital General de Zona no. 24 IMSS. Poza Rica, Veracruz [in Spanish]. Arch Cardiol Mex 76: 269276. [Google Scholar]
  8. Segura EL, Escobar-Mesa A, , 2005. Epidemiología de la enfermedad de Chagas en el estado de Veracruz. Salud Publica Mex 47: 201208.[Crossref] [Google Scholar]
  9. Sanchez B, Monteon V, Reyes PA, Espinoza B, , 2001. Standardization of micro-enzymes-linked immunosorbent assay (ELISA) and western blot for detection of Trypanosoma cruzi antibodies using extracts from Mexican strains as antigens. Arch Med Res 32: 382388.[Crossref] [Google Scholar]
  10. Rangel-Flores H, Sanchez B, Mendoza-Duarte J, Barnabe C, Breniere FS, Ramos C, Espinoza B, , 2001. Serologic and parasitologic demonstration of Trypanosoma cruzi infections in an urban area of central Mexico: correlation with electrocardiographic alterations. Am J Trop Med Hyg 65: 887895. [Google Scholar]
  11. Monteon VM, Ramos A, Reyes PA, , 1993. Reactivity of sera from Chagas patients to extracts of Mexican Trypanosoma cruzi isolates [in Spanish]. Rev Biol Trop 41: 861865. [Google Scholar]
  12. Luquetti AO, Espinoza B, Martinez I, Hernandez-Becerril N, Ponce C, Ponce E, Reyes PA, Hernandez O, Lopez R, Monteon V, , 2009. Performance levels of four Latin American laboratories for the serodiagnosis of Chagas disease in Mexican sera samples. Mem Inst Oswaldo Cruz 104: 797800.[Crossref] [Google Scholar]
  13. Dorn PL, Monroy C, Curtis A, , 2007. Triatoma dimidiata (Latreille, 1811): a review of its diversity across its geographic range and the relationship among populations. Infect Genet Evol 7: 343352.[Crossref] [Google Scholar]
  14. Ibarra-Cerdena CN, Sanchez-Cordero V, Townsend Peterson A, Ramsey JM, , 2009. Ecology of North American Triatominae. Acta Trop 110: 178186.[Crossref] [Google Scholar]
  15. Dumonteil E, Gourbière S, , 2004. Prediction of Triatoma dimidiata vector abundance and infection rate: a risk map for Trypanosoma cruzi natural transmission in the Yucatan peninsula of Mexico. Am J Trop Med Hyg 70: 514519. [Google Scholar]
  16. Bustamante DM, Monroy C, Rodas A, Juarez J, Malone JB, , 2007. Environmental determinants of the distribution of Chagas disease vectors in southeastern Guatemala. Geospatial Health 2: 199211.[Crossref] [Google Scholar]
  17. Biancardi MA, Conca Moreno M, Torres N, Pepe C, Altcheh J, Freilij H, , 2003. Seroprevalencia de la enfermedad de Chagas en 17 parajes del “Monte Impenetrable” de la Provincia del Chaco. Medicina (B Aires) 63: 125129. [Google Scholar]
  18. Medrano-Mercado N, Ugarte-Fernandez R, Butron V, Uber-Busek S, Guerra HL, Araujo-Jorge TC, Correa-Oliveira R, , 2008. Urban transmission of Chagas disease in Cochabamba, Bolivia. Mem Inst Oswaldo Cruz 103: 423430.[Crossref] [Google Scholar]
  19. Albarracin-Veizaga H, Carvalho ME, Nascimento EM, Rodrigues VL, Casanova C, Barata JM, , 1999. Chagas disease in an area of recent occupation in Cochabamba, Bolivia. Rev Saude Publica 33: 230236.[Crossref] [Google Scholar]
  20. Bowman NM, Kawai V, Levy MZ, Cornejo del Carpio JG, Cabrera L, Delgado F, Malaga F, Cordova Benzaquen E, Pinedo VV, Steurer F, Seitz AE, Gilman RH, Bern C, , 2008. Chagas disease transmission in periurban communities of Arequipa, Peru. Clin Infect Dis 46: 18221828.[Crossref] [Google Scholar]
  21. Gurtler RE, Kitron U, Cecere MC, Segura EL, Cohen JE, , 2007. Sustainable vector control and management of Chagas disease in the Gran Chaco, Argentina. Proc Natl Acad Sci USA 104: 1619416199.[Crossref] [Google Scholar]
  22. Montoya R, Dias JC, Coura JR, , 2003. Chagas disease in a community in southeast Brazil. I. A serologic follow-up study on a vector controlled area. Rev Inst Med Trop Sao Paulo 45: 269274.[Crossref] [Google Scholar]
  23. Mazariego-Arana MA, Monteon VM, Ballinas-Verdugo MA, Hernandez-Becerril N, Alejandre-Aguilar R, Reyes PA, , 2001. Seroprevalence of human Trypanosoma cruzi infection in different geografic zones of Chiapas, Mexico. Rev Soc Bras Med Trop 34: 453458.[Crossref] [Google Scholar]
  24. Greer GJ, Nix NA, Cordon-Rosales C, Hernandez B, MacVean CM, Powell MR, , 1999. Seroprevalence of Trypanosoma cruzi infection in three rural communities in Guatemala. Rev Panam Salud Publica 6: 110116.[Crossref] [Google Scholar]
  25. Buekens P, Almendares O, Carlier Y, Dumonteil E, Eberhard M, Gamboa-Leon R, James M, Padilla N, Wesson D, Xiong X, , 2008. Mother-to-child transmission of Chagas' disease in North America: why don't we do more? Matern Child Health J 12: 283286.[Crossref] [Google Scholar]
  26. Sanchez Negrette O, Mora MC, Basombrio MA, , 2005. High prevalence of congenital Trypanosoma cruzi infection and family clustering in Salta, Argentina. Pediatrics 115: e668e672.[Crossref] [Google Scholar]
  27. Olivera Mar A, Guillen Ortega F, Cruz Vidal S, Hernandez-Becerril N, Perez Galdamez E, Cordova Concepcion G, Reyes PA, Monteon VM, , 2006. Serological and parasitological screening of Trypanosoma cruzi infection in mothers and newborns living in two Chagasic areas of Mexico. Arch Med Res 37: 774777.[Crossref] [Google Scholar]
  28. Mott KE, Lehman JS, Jr Hoff R, Morrow RH, Muniz TM, Sherlock I, Draper CC, Pugliese C, Guimaraes AC, , 1976. The epidemiology and household distribution of seroreactivity to Trypanosoma cruzi in a rural community in northeast Brazil. Am J Trop Med Hyg 25: 552562. [Google Scholar]

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  • Received : 11 Nov 2009
  • Accepted : 06 Mar 2010
  • Published online : 06 Jul 2010

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