Volume 83, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



We conducted this study to determine the prognostic significance of the platelet count in children with cerebral malaria. We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis. There was a significant difference in platelet counts between children with cerebral malaria and those with meningitis. Among children with cerebral malaria, there was no relationship between the platelet count and either the admission coma score or the eventual outcome. Those with malarial retinopathy were more thrombocytopenic than those without. Our results suggest that the platelet count is not prognostic in Malawian children with cerebral malaria.


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  1. Ladhani S, Lowe B, Cole AO, Kouwondo K, Newton CR, , 2002. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol 119: 839847.[Crossref] [Google Scholar]
  2. Wickramasinghe SN, Abdalla SH, , 2000. Blood and bone marrow in malaria. Best Pract Res Clin Haematol 13: 277299.[Crossref] [Google Scholar]
  3. Taha K, El-Dein SZ, Idrees M, Makboul G, Baidas G, , 2007. Haematological changes in malaria in relation to Plasmodium species. Kuwait Med J 39: 262267. [Google Scholar]
  4. Gerardin P, Roger C, Ka AS, Jouvencel P, Brousse V, Imbert P, , 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66: 686691. [Google Scholar]
  5. Taylor TE, Fu WN, Carr RA, Whitten RO, Mueller JG, Fosiko NM, Liomba NG, Molyneux ME, , 2004. Differentiating the pathologies of cerebral malaria by post mortem parasite counts. Nat Med 10: 143145.[Crossref] [Google Scholar]
  6. Beare NA, Taylor TE, Harding SP, Lewallen S, Molyneux ME, , 2006. Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg 75: 790797. [Google Scholar]
  7. Kelton JG, Keystone J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jewen J, , 1983. Immune-mediated thrombocytopenia of malaria. J Clin Invest 71: 832836.[Crossref] [Google Scholar]
  8. Kreil A, Wenisch C, Brittenham G, Looreesvwan S, Peck-Radosavljevic M, , 2000. Thrombopoietin in Plasmodium falciparum malaria. Br J Haematol 109: 534536.[Crossref] [Google Scholar]
  9. Mwangi TW, Ross A, Snow RW, Marsh K, , 2005. Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis 191: 19321939.[Crossref] [Google Scholar]
  10. Smith T, Charwood JD, Kihonda J, Mwankusye S, Billingsley P, Meuwissen J, Lyimo E, Takken W, Teuscher T, Tanner M, , 1993. Absence of seasonal variation in malaria parasitaemia in an area of intense seasonal transmission. Acta Trop 54: 5572.[Crossref] [Google Scholar]
  11. Wassmer SC, Combes V, Grau GE, , 2003. Pathophysiology of cerebral malaria: role of host cells in the modulation of cytoadhesion. Ann N Y Acad Sci 992: 3038.[Crossref] [Google Scholar]
  12. Grau E, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME, , 2003. Platelet accumulation in brain microvessels in fatal paediatric cerebral malaria. J Infect Dis 187: 461466.[Crossref] [Google Scholar]
  13. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, , 1989. Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med 71: 441459. [Google Scholar]

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  • Received : 12 Oct 2009
  • Accepted : 08 Feb 2010
  • Published online : 06 Jul 2010

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