Volume 82, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The aim of this study was to investigate the factors associated with acute kidney injury (AKI) in patients with visceral leishmaniasis (VL). The study patients had a diagnosis of VL and were admitted to a tertiary hospital. A multivariate analysis was performed to analyze the risk factors for AKI. A total of 224 patients were included. The mean age was 36 ± 15 years. AKI was observed in 33.9% of cases. Risk factors associated with AKI were male gender (odds ratio [OR] = 2.2; = 0.03), advanced age (OR = 1.05; < 0.001), and jaundice (OR = 2.9; = 0.002). There was an association between amphotericin B use and AKI (OR = 18.4; < 0.0001), whereas glucantime use was associated with lower incidence of AKI compared with amphotericin B use (OR = 0.05; < 0.0001). Mortality was 13.3%, and it was higher in AKI patients (30.2%). Therefore, factors associated with AKI were male gender, advanced age, and jaundice. Amphotericin B was an important cause of AKI in VL.


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  • Received : 20 Sep 2009
  • Accepted : 29 Nov 2009
  • Published online : 05 Mar 2010

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