1921
Volume 82, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity, ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3–8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses. Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.

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References

  1. Nimmannitya S, Gubler DJ, Kuno G, , 1997. Dengue hemorrhagic fever: diagnosis and management. , eds. Dengue and Dengue Hemorrhagic Fever. New York: CAB International, 133146. [Google Scholar]
  2. Pinheiro FP, Corber SJ, , 1997. Global situation of dengue and dengue haemorrhagic fever, and its emergence in the Americas. World Health Stat Q 50: 161169. [Google Scholar]
  3. International Vaccine Institute, 2009. Global burden of dengue. Available at: http://www.pdvi.org/about_dengue/GBD.asp. Accessed July 16, 2009. [Google Scholar]
  4. Hammond SN, Balmaseda A, Perez L, Tellez Y, Saborio SI, Mercado JC, Videa E, Rodriguez Y, Perez MA, Cuadra R, Solano S, Rocha J, Idiaquez W, Gonzalez A, Harris E, , 2005. Differences in dengue severity in infants, children, and adults in a 3-year hospital-based study in Nicaragua. Am J Trop Med Hyg 73: 10631070. [Google Scholar]
  5. Tsai CJ, Kuo CH, Chen PC, Changcheng CS, , 1991. Upper gastrointestinal bleeding in dengue fever. Am J Gastroenterol 86: 3335. [Google Scholar]
  6. Wills BA, Oragui EE, Dung NM, Loan HT, Chau NV, Farrar JJ, Levin M, , 2004. Size and charge characteristics of the protein leak in dengue shock syndrome. J Infect Dis 190: 810818.[Crossref] [Google Scholar]
  7. Halstead SB, , 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239: 476481.[Crossref] [Google Scholar]
  8. Sabin A, , 1952. Research on dengue during World War II. Am J Trop Med Hyg 1: 3050. [Google Scholar]
  9. Burke DS, Nisalak A, Johnson DE, Scott RM, , 1988. A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 38: 172180. [Google Scholar]
  10. Endy TP, Nisalak A, Chunsuttitwat S, Vaughn DW, Green S, Ennis FA, Rothman AL, Libraty DH, , 2004. Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis 189: 9901000.[Crossref] [Google Scholar]
  11. Guzman MG, Kouri GP, Bravo J, Soler M, Vazquez S, Morier L, , 1990. Dengue hemorrhagic fever in Cuba, 1981: a retrospective seroepidemiologic study. Am J Trop Med Hyg 42: 179184. [Google Scholar]
  12. Kalayanarooj S, Nimmannitya S, , 2003. Clinical presentations of dengue hemorrhagic fever in infants compared to children. J Med Assoc Thai 86 (Suppl 3): S673S680. [Google Scholar]
  13. Halstead SB, Lan NT, Myint TT, Shwe TN, Nisalak A, Kalyanarooj S, Nimmannitya S, Soegijanto S, Vaughn DW, Endy TP, , 2002. Dengue hemorrhagic fever in infants: research opportunities ignored. Emerg Infect Dis 8: 14741479.[Crossref] [Google Scholar]
  14. Halstead SB, Scanlon JE, Umpaivit P, Udomsakdi S, , 1969. Dengue and chikungunya virus infection in man in Thailand, 1962–1964. IV. Epidemiologic studies in the Bangkok metropolitan area. Am J Trop Med Hyg 18: 9971021. [Google Scholar]
  15. Libraty DH, Acosta LP, Tallo V, Segubre-Mercado E, Bautista A, Potts JA, Jarman RG, Yoon IK, Gibbons RV, Brion JD, Capeding RZ, , 2009. A prospective nested case-control study of dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model. PLoS Med 6: e1000171.[Crossref] [Google Scholar]
  16. Klungthong C, Gibbons RV, Thaisomboonsuk B, Nisalak A, Kalayanarooj S, Thirawuth V, Nutkumhang N, Mammen MP, Jr Jarman RG, , 2007. Dengue virus detection using whole blood for reverse transcriptase PCR and virus isolation. J Clin Microbiol 45: 24802485.[Crossref] [Google Scholar]
  17. Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH, , 1989. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 40: 418427. [Google Scholar]
  18. Clarke DH, Casals J, , 1958. Techniques for hemagglutination and hemagglutination-inhibition with arthropod borne viruses. Am J Trop Med Hyg 7: 561573. [Google Scholar]
  19. Anonymous, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva: WHO. [Google Scholar]
  20. Kabilan L, Balasubramanian S, Keshava SM, Thenmozhi V, Sekar G, Tewari SC, Arunachalam N, Rajendran R, Satyanarayana K, , 2003. Dengue disease spectrum among infants in the 2001 dengue epidemic in Chennai, Tamil Nadu, India. J Clin Microbiol 41: 39193921.[Crossref] [Google Scholar]
  21. Nguyen TH, Lei HY, Nguyen TL, Lin YS, Huang KJ, Le BL, Lin CF, Yeh TM, Do QH, Vu TQ, Chen LC, Huang JH, Lam TM, Liu CC, Halstead SB, , 2004. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis 189: 221232.[Crossref] [Google Scholar]
  22. Simmons CP, Chau TN, Thuy TT, Tuan NM, Hoang DM, Thien NT, Lien le B, Quy NT, Hieu NT, Hien TT, McElnea C, Young P, Whitehead S, Hung NT, Farrar J, , 2007. Maternal antibody and viral factors in the pathogenesis of dengue virus in infants. J Infect Dis 196: 416424.[Crossref] [Google Scholar]
  23. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA, , 2002. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol 156: 4051.[Crossref] [Google Scholar]
  24. Hubert B, Halstead SB, , 2009. Dengue 1 virus and dengue hemorrhagic fever, French Polynesia, 2001. Emerg Infect Dis 15: 12651270.[Crossref] [Google Scholar]
  25. Potts JA, Rothman AL, , 2008. Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations. Trop Med Int Health 13: 13281340.[Crossref] [Google Scholar]
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  • Received : 11 Sep 2009
  • Accepted : 16 Nov 2009
  • Published online : 05 Feb 2010

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