1921
Volume 83, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

In 2004, Sudan adopted artesunate + sulfadoxine/pyrimethamine (SP) combination as the first-line drug, in response to the high level of resistance to antimalarials. In 2007, a molecular study on antimalarial resistance linked genes, , , , , and , was conducted on 198 isolates from central and eastern Sudan. We observed a high frequency of point mutations at almost all loci analyzed, mainly of 76T (72.7%), 51I (75.3%), and 108N (72.7%) alleles. The MARK III test for chloroquine sensitivity in 45 isolates showed that 37.8% of the isolates were low resistant and 6.7% were fully resistant. This study represents the most recent molecular investigation on antimalarial resistance in this area after the adoption of artemisinin-based combination therapy (ACT), and underlines the importance of the analysis of SP resistance evolution to monitor the efficacy of ACT therapy in endemic areas.

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  • Received : 02 Sep 2009
  • Accepted : 26 Apr 2010

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