1921
Volume 82, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

is a gram-negative bacillus that causes the highly contagious disease known as pertussis or whooping cough. Antibody response in children may vary depending on the vaccination schedule and the product used. In this study, we have analyzed the antibody response of cellular pertussis vaccinated children against strains and their virulence factors, such as pertussis toxin, pertactin, and filamentous hemagglutinin. After the completion of the immunization process, according to the Brazilian vaccination program, children serum samples were collected at different periods of time, and tested for the presence of specific antibodies and antigenic cross-reactivity. Results obtained show that children immunized with three doses of the Brazilian whole-cell pertussis vaccine present high levels of serum antibodies capable of recognizing the majority of the components present in vaccinal and non-vaccinal strains and their virulence factors for at least 2 years after the completion of the immunization procedure.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.09-0486
2010-04-01
2017-09-24
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/4/678.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0486&mimeType=html&fmt=ahah

References

  1. Forsyth KD, von König CH, Tan T, Caro J, Plotkin S, , 2007. Prevention of pertussis: recommendations derived from the second Global Pertussis Initiative roundtable meeting. Vaccine 25: 26342642.[Crossref]
  2. Tan T, Trindade E, Skowronski D, , 2005. Epidemiology of pertussis. Pediatr Infect Dis J 24: S10S18.[Crossref]
  3. Cherry JD, , 2006. Epidemiology of pertussis. Pediatr Infect Dis J 25: 361362.[Crossref]
  4. Edwards K, Freeman DM, , 2006. Adolescent and adult pertussis: disease burden and prevention. Curr Opin Pediatr 18: 7780.[Crossref]
  5. Celentano LP, Massari M, Paramatti D, Salmaso S, Tozzi AE, , 2005. Resurgence of pertussis in Europe. Pediatr Infect Dis J 24: 761765.[Crossref]
  6. Cherry JD, Grimprel E, Guiso N, Heininger U, Mertsola J, , 2005. Defining pertussis epidemiology clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J 24: S25S34.[Crossref]
  7. Bamberger ES, Srugo I, , 2008. What is new in pertussis. Eur J Pediatr 167: 133139.[Crossref]
  8. Matoo S, Cherry JD, , 2005. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev 18: 326382.[Crossref]
  9. Le T, Cherry JD, Chang SJ, Knoll MD, Lee ML, Barenkamp S, Bernstein D, Edelman R, Edwards KM, Greenberg D, Keitel W, Treanor J, Ward JI, APERT Study, 2004. Immune responses and antibody decay after immunization of adolescents and adults with an acellular pertussis vaccine: the APERT Study. J Infect Dis 190: 535544.[Crossref]
  10. Ward JI, Cherry JD, Chang SJ, Partridge S, Lee H, Treanor J, Greenberg DP, Keitel W, Barenkamp S, Bernstein DI, Edelman R, Edwards K, APERT Study Group, 2005. Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med 353: 15551563.[Crossref]
  11. Willems RJL, Mooi FR, , 1996. From whole-cell to acellular vaccine. Rev Med Microbiol 7: 1321.[Crossref]
  12. World Health Organization, 2001. Annual Report 2000, Vaccines and Biologicals. Geneva: World Health Organization.
  13. Campins-Marti M, Cheng HK, Forsyth K, Guiso N, Halperin S, Huang LM, Mertsola J, Oselka G, Ward J, Wirsing van Konig CH, Zeep F, , 2001. Recommendations are needed for adolescent and adult pertussis immunization: rationale and strategies for consideration. Vaccine 20: 641646.[Crossref]
  14. Pereira A, Pereira ASP, Moreira-Filho CA, Bando SY, Tambourgi DV, , 2005. Comparative analysis of a Bordetella pertussis patient isolated strain and classical strains used in the pertussis vaccine. Vaccine 23: 43534358.[Crossref]
  15. Bordet J, Gengou O, , 1906. Le microbe de la coqueluche. Ann Inst Pasteur (Paris) 20: 731741.
  16. Stainer DW, Scholte MJ, , 1970. A simple chemically defined medium for the production of phase I Bordetella pertussis . J Gen Microbiol 63: 211220.[Crossref]
  17. Laemmli UK, , 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680685.[Crossref]
  18. Towbin H, Staehelin T, Gordon J, , 1992. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Biotechnology 24: 145149.
  19. Matoo S, Cherry JD, , 2005. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev 18: 326382.[Crossref]
  20. Tran Minh NN, Edelman K, He Q, Viljanen MK, Arvilommi H, Mertsola J, , 1998. Antibody and cell-mediated immune responses to booster immunization with a new acellular pertussis vaccine in school children. Vaccine 16: 16041610.[Crossref]
  21. Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J, , 1996. A controlled trial of a two-component acellular, a five-component acellular, and a whole cell pertussis vaccine. N Engl J Med 334: 349355.[Crossref]
  22. Brasil. Ministério da Saúde. Fundação Nacional de Saúde, 2002. Guia Brasileiro de Vigilância Epidemiológica, 5th ed. Brasília: FUNASA 1: 183199.
  23. Garcia-Corbeira P, Dal Re R, Aguilar L, Garcia-deLomas J, , 2000. Seroepidemiology of Bordetella pertussis infections in the Spanish population: a cross sectional study. Vaccine 18: 21732176.[Crossref]
  24. Hewlet EL, , 1997. Pertussis: current concepts of pathogenesis and prevention. Pediatr Infect Dis J 16: S78S84.[Crossref]
  25. Leininger E, Roberts M, Kenimer JG, Charles IG, Fairweather N, Novotiny P, Brennan MJ, , 1991. Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells. Proc Natl Acad Sci USA 88: 345349.[Crossref]
  26. Mouton D, Sant'Anna OA, Biozzi G, , 1998. Multigenic control of specific and non-specific immunity in mice: a review. Livest Prod Sci 20: 277286.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0486
Loading
/content/journals/10.4269/ajtmh.2010.09-0486
Loading

Data & Media loading...

  • Received : 21 Aug 2009
  • Accepted : 12 Oct 2009

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error