Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg), recently described to have promising antischistosomal properties, against juvenile and adult in T cell-deficient and in comparably infected age- and sex-matched immunologically intact control mice. Artemether and mefloquine are equally effective in athymic and immunocompetent mice. Artemether treatment resulted in total and female worm burden reductions ranging between 71.1% and 85.3%, whereas mefloquine achieved total and female worm burden reductions of 80.4–97.8%. In conclusion, artemether and mefloquine act T-cell independently and no synergistic interaction with the immune response was involved.


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  1. Keiser J, Utzinger J, , 2007. Artemisinins and synthetic trioxolanes in the treatment of helminth infections. Curr Opin Infect Dis 20: 605612.[Crossref]
  2. Utzinger J, Xiao SH, Tanner M, Keiser J, , 2007. Artemisinins for schistosomiasis and beyond. Curr Opin Investig Drugs 8: 105116.
  3. Keiser J, Chollet J, Xiao SH, Mei JY, Jiao PY, Utzinger J, Tanner M, , 2009. Mefloquine-an aminoalcohol with promising antischistosomal properties in mice. PLoS Negl Trop Dis 3: e350.[Crossref]
  4. Xiao SH, Shen BG, Chollet J, Utzinger J, Tanner M, , 2001. Tegumental alterations in juvenile Schistosoma haematobium harboured in hamsters following artemether treatment. Parasitol Int 50: 175183.[Crossref]
  5. Wang JX, Tang W, Shi LP, Wan J, Zhou R, Ni J, Fu YF, Yang YF, Li Y, Zuo JP, , 2007. Investigation of the immunosuppressive activity of artemether on T-cell activation and proliferation. Br J Pharmacol 150: 652661.[Crossref]
  6. Sabah AA, Fletcher C, Webbe G, Doenhoff MJ, , 1985. Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell-deprived mice. Exp Parasitol 60: 348354.[Crossref]
  7. Doenhoff MJ, , 1989. The immune-dependence of chemotherapy in experimental schistosomiasis. Mem Inst Oswaldo Cruz 84: 3137.[Crossref]
  8. Brindley PJ, Sher A, , 1987. The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response. J Immunol 139: 215220.
  9. Buchanan RD, Fine DP, Colley DG, , 1973. Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. II. Pathology and altered pathogenesis. Am J Pathol 71: 207218.
  10. Byram JE, von Lichtenberg F, , 1977. Altered schistosome granuloma formation in nude mice. Am J Trop Med Hyg 26: 944956.
  11. Byram JE, Doenhoff MJ, Musallam R, Brink LH, von Lichtenberg F, , 1979. Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. II. Pathology. Am J Trop Med Hyg 28: 274285.
  12. Gargione C, Vellosa SA, Hoshino-Shimizu S, Okumura M, Chiodelle SG, , 1998. Immunosuppression and parasitic diseases: experimental schistosomiasis mansoni . Rev Hosp Clin Fac Med Sao Paulo 53: 122128.
  13. Watanabe K, Mwinzi PN, Black CL, Muok EM, Karanja DM, Secor WE, Colley DG, , 2007. T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment. Am J Trop Med Hyg 77: 676682.
  14. Xiao SH, Guo J, Chollet J, Wu JT, Tanner M, Utzinger J, , 2004. Effect of artemether on Schistosoma mansoni: dose-efficacy relationship, and changes in worm morphology and histopathology. Chinese Journal of Parasitology and Parasitic Diseases 22: 148153.
  15. Utzinger J, Chollet J, Tu ZW, Xiao SH, Tanner M, , 2002. Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice. Trans R Soc Trop Med Hyg 96: 318323.[Crossref]
  16. Botros SS, Mahmoud MR, Moussa MM, Nosseir MM, , 2007. Immunohistopathological and biochemical changes in Schistosoma mansoni-infected mice treated with artemether. J Infect 55: 470477.[Crossref]
  17. Ammann P, Waldvogel A, Breyer I, Esposito M, Muller N, Gottstein B, , 2004. The role of B- and T-cell immunity in toltrazuril-treated C57BL/6 WT, microMT and nude mice experimentally infected with Neospora caninum . Parasitol Res 93: 178187.[Crossref]
  18. Harnett W, Kusel JR, , 1986. Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro . Parasitology 93: 401405.[Crossref]
  19. Manneck T, Haggenmüller Y, Keiser J, , 2009. Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni . Parasitology (in press). doi:10.1017/S0031182009990965
  20. Xiao SH, Shen BG, Chollet J, Utzinger J, Tanner M, , 2000. Tegumental changes in adult Schistosoma mansoni harbored in mice treated with artemether. J Parasitol 86: 11251132.[Crossref]

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  • Received : 10 Aug 2009
  • Accepted : 28 Sep 2009

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