1921
Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

We report a case of visceral leishmaniasis in a human immunodeficiency virus (HIV)-infected 37-year-old Thai fisherman who presented with nephritonephrotic syndrome, fever, anemia, and thrombocytopenia. Bone marrow biopsy revealed many amastigotes within macrophages. Kidney biopsy showed membranoproliferative glomerulonephritis. Polymerase chain reaction (PCR) and nucleotide sequence analysis of the internal transcribed spacer 1 of the small subunit ribosomal RNA gene in blood and kidney biopsy specimens showed species previously described in a Thai patient with visceral leishmaniasis. Only four autochthonous cases of leishmaniasis have been reported in Thailand since 1996. To the best of our knowledge, this is the first report of autochthonous visceral leishmaniasis in an HIV-infected Thai. With an increasing number of patients with autochthonous leishmaniasis in association with the presence of potential vector, it remains to be determined whether this vector-borne disease will become an emerging infectious disease in Thailand.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.09-0434
2010-01-01
2017-11-22
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/1/004.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0434&mimeType=html&fmt=ahah

References

  1. Desjeux P, , 1996. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27: 305318.[Crossref]
  2. Guerin PJ, Olliaro P, Sundar S, Boelaert M, Croft SL, Desjeux P, Wasunna MK, Bryceson AD, , 2002. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2: 494501.[Crossref]
  3. Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S, , 2007. Cutaneous leishmaniasis. Lancet Infect Dis 7: 581596.[Crossref]
  4. Suttinont P, Thammanichanont C, Chantarakul N, , 1987. Visceral leishmaniasis: a case report. Southeast Asian J Trop Med Public Health 18: 103106.
  5. Viriyavejakul P, Viravan C, Riganti M, Punpoowong B, , 1997. Imported cutaneous leishmaniasis in Thailand. Southeast Asian J Trop Med Public Health 28: 558562.
  6. Thisyakorn U, Jongwutiwes S, Vanichsetakul P, Lertsapcharoen P, , 1999. Visceral leishmaniasis: the first indigenous case report in Thailand. Trans R Soc Trop Med Hyg 93: 2324.[Crossref]
  7. Kongkaew W, Siriarayaporn P, Leelayoova S, Supparatpinyo K, Areechokchai D, Duang-ngern P, Chanachai K, Sukmee T, Samung Y, Sridurongkathum P, , 2007. Autochthonous visceral leishmaniasis: a report of a second case in Thailand. Southeast Asian J Trop Med Public Health 38: 812.
  8. Sukmee T, Siripattanapipong S, Mungthin M, Worapong J, Rangsin R, Samung Y, Kongkaew W, Bumrungsana K, Chanachai K, Apiwathanasorn C, Rujirojindakul P, Wattanasri S, Ungchusak K, Leelayoova S, , 2008. A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient. Int J Parasitol 38: 617622.[Crossref]
  9. Maharom P, Siripattanapipong S, Mungthin M, Naaglor T, Sukkawee R, Pudkorn R, Wattana W, Wanachiwanawin D, Areechokchai D, Leelayoova S, , 2008. Visceral leishmaniasis caused by Leishmania infantum in Thailand. Southeast Asian J Trop Med Public Health 39: 988990.
  10. Apiwathnasorn C, Sucharit S, Rongsriyam Y, Leemingsawat S, Kerdpibule V, Deesin T, Surathin K, Vutikes S, Punavuthi N, , 1989. A brief survey of phlebotomine sandflies in Thailand. Southeast Asian J Trop Med Public Health 20: 429432.
  11. Apiwathnasorn C, Sucharit S, Surathin K, Deesin T, , 1993. Anthropophilic and zoophilic phlebotomine sand flies (Diptera: Psychodidae) from Thailand. J Am Mosq Control Assoc 9: 135137.
  12. Polseela R, Apiwathnasorn C, Samung Y, , 2007. Seasonal variation of cave-dwelling phlebotomine sandflies (Diptera:Psychodidae) in Phra Phothisat Cave, Saraburi Province, Thailand. Southeast Asian J Trop Med Public Health 38: 10111015.
  13. Le Fichoux Y, Quaranta JF, Aufeuvre JP, Lelievre A, Marty P, Suffia I, Rousseau D, Kubar J, , 1999. Occurrence of Leishmania infantum parasitemia in asymptomatic blood donors living in an area of endemicity in southern France. J Clin Microbiol 37: 19531957.
  14. Uliana SR, Nelson K, Beverley SM, Camargo EP, Floeter-Winter LM, , 1994. Discrimination amongst Leishmania by polymerase chain reaction and hybridization with small subunit ribosomal DNA derived oligonucleotides. J Eukaryot Microbiol 41: 324330.[Crossref]
  15. Alex S, Criado C, Fernández-Guerrero ML, de Górgolas M, Petkov V, Garcia Perez A, Egido J, Barat A, Manzarbeitia F, Caramelo C, Ortiz A, , 2008. Nephrotic syndrome complicating chronic visceral leishmaniasis: re-emergence in patients with AIDS. Clin Nephrol 70: 6568.[Crossref]
  16. Efstratiadis G, Boura E, Giamalis P, Mandala E, Leontsini M, Tsiaousis G, Memmos D, , 2006. Renal involvement in a patient with visceral leishmaniasis. Nephrol Dial Transplant 21: 235236.[Crossref]
  17. Dutra M, Martinelli R, de Carvalho EM, Rodrigues LE, Brito E, Rocha H, , 1985. Renal involvement in visceral leishmaniasis. Am J Kidney Dis 6: 2227.[Crossref]
  18. Herwaldt BL, , 1999. Leishmaniasis. Lancet 354: 11911199.[Crossref]
  19. Rodriguez-Bonfante C, Bonfante-Garrido R, Grimaldi G Jr, Momen H, Cupolillo E, , 2003. Genotypically distinct Leishmania colombiensis isolates from Venezuela cause both cutaneous and visceral leishmaniasis in humans. Infect Genet Evol 3: 119124.[Crossref]
  20. Schallig HD, Schoone GJ, Kroon CC, Hailu A, Chappuis F, Veeken H, , 2001. Development and application of ‘simple’ diagnostic tools for visceral leishmaniasis. Med Microbiol Immunol (Berl) 190: 6971.[Crossref]
  21. Abranches P, Campino L, Santos-Gomes GM, , 1998. Canine leishmaniasis. New concepts of epidemiology and immunopathology: their impact in the control of human visceral leishmaniasis. Acta Med Port 11: 871875.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0434
Loading
/content/journals/10.4269/ajtmh.2010.09-0434
Loading

Data & Media loading...

  • Received : 28 Jul 2009
  • Accepted : 05 Oct 2009

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error