Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



Chagas disease is a major vector-borne disease, and regional initiatives based on insecticide spraying have successfully controlled domiciliated vectors in many regions. Non-domiciliated vectors remain responsible for a significant transmission risk, and their control is a challenge. We performed a proof-of-concept field trial to test alternative strategies in rural Yucatan, Mexico. Follow-up of house infestation for two seasons following the interventions confirmed that insecticide spraying should be performed annually for the effective control of ; however, it also confirmed that insect screens or long-lasting impregnated curtains may represent good alternative strategies for the sustained control of these vectors. Ecosystemic peridomicile management would be an excellent complementary strategy to improve the cost-effectiveness of interventions. Because these strategies would also be effective against other vector-borne diseases, such as malaria or dengue, they could be integrated within a multi-disease control program.


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  1. Moncayo AC, Ortiz Yanine MI, , 2006. An update on Chagas disease (human American trypanosomiasis). Ann Trop Med Parasitol 100: 663677.[Crossref] [Google Scholar]
  2. Schofield CJ, Jannin J, Salvatella R, , 2006. The future of Chagas disease control. Trends Parasitol 22: 583588.[Crossref] [Google Scholar]
  3. Pinto Dias JC, , 2006. Chagas disease: successes and challenges. Cad Saude Publica 22: 20202021.[Crossref] [Google Scholar]
  4. Sanchez-Martin MJ, Feliciangeli MD, Campbell-Lendrum D, Davies CR, , 2006. Could the Chagas disease elimination program in Venezuela be compromised by reinvasion of houses by sylvatic Rhodnius prolixus bug populations? Trop Med Int Health 11: 15851593.[Crossref] [Google Scholar]
  5. Carbajal de la Fuente AL, Minoli SA, Lopes CM, Noireau F, Lazzari CR, Lorenzo MG, , 2007. Flight dispersal of the Chagas disease vectors Triatoma brasiliensis and Triatoma pseudomaculata in northeastern Brazil. Acta Trop 101: 115119.[Crossref] [Google Scholar]
  6. Salazar Schettino PM, Rosales Pina JS, Rojas Wastavino G, Cabrera Bravo M, Vences Blanco M, Lopez Cardenas J, , 2007. Triatoma mexicana (Hemiptera: Reduviidae) in Guanajuato, Mexico: house infestation and seasonal variation. Mem Inst Oswaldo Cruz 102: 803807.[Crossref] [Google Scholar]
  7. Dumonteil E, Gourbière S, Barrera-Perez M, Rodriguez-Felix E, Ruiz-Piña H, Baños-Lopez O, Ramirez-Sierra MJ, Menu F, Rabinovich JE, , 2002. Geographic distribution of Triatoma dimidiata and transmission dynamics of Trypanosoma cruzi in the Yucatan peninsula of Mexico. Am J Trop Med Hyg 67: 176183. [Google Scholar]
  8. Polonio R, Ramirez-Sierra MJ, Dumonteil E, , 2009. Dynamics and distribution of house infestation by Triatoma dimidiata in central and southern Belize. Vector Borne Zoonotic Dis 9: 1924.[Crossref] [Google Scholar]
  9. Harry M, Lema F, Romana CA, , 2000. Chagas' disease challenge. Lancet 355: 236.[Crossref] [Google Scholar]
  10. Schofield CJ, , 2000. Challenges of Chagas disease vector control in Central America. WHO, ed. Global Collaboration for Development of Pesticides for Public Health (GCDPP). Geneva, Switzerland: WHO, WHO/CDS/WHOPES/GCDPP/2000.1. [Google Scholar]
  11. Miles MA, Feliciangeli MD, Rojas de Arias A, , 2003. American trypanosomiasis (Chagas' disease) and the role of molecular epidemiology in guiding control strategy. BMJ 326: 14441448.[Crossref] [Google Scholar]
  12. Dumonteil E, Ruiz-Pina H, Rodriguez-Felix E, Barrera-Perez M, Ramirez-Sierra MJ, Rabinovich JE, Menu F, , 2004. Re-infestation of houses by Triatoma dimidiata after intra-domicile insecticide application in the Yucatan peninsula, Mexico. Mem Inst Oswaldo Cruz 99: 253256.[Crossref] [Google Scholar]
  13. Barbu C, Dumonteil E, Gourbiere S, , 2009. Optimization of control strategies for non-domiciliated Triatoma dimidiata, Chagas disease vector in the Yucatán peninsula, Mexico. PLoS Negl Trop Dis 3: e416.[Crossref] [Google Scholar]
  14. Vassena CV, Picollo MI, Zerba EN, , 2000. Insecticide resistance in Brazilian Triatoma infestans and Venezuelan Rhodnius prolixus . Med Vet Entomol 14: 5155.[Crossref] [Google Scholar]
  15. Ponce C, , 2007. Current situation of Chagas disease in Central America. Mem Inst Oswaldo Cruz 102 (Suppl 1): 4144.[Crossref] [Google Scholar]
  16. Dumonteil E, Tripet F, Ramirez-Sierra MJ, Payet V, Lanzaro G, Menu F, , 2007. Assessment of Triatoma dimidiata dispersal in the Yucatan peninsula of Mexico using morphometry and microsatellite markers. Am J Trop Med Hyg 76: 930937. [Google Scholar]
  17. Payet V, Ramirez-Sierra MJ, Rabinovich J, Menu F, Dumonteil E, , 2009. Variations in sex-ratio, feeding and fecundity of Triatoma dimidiata between habitats in the Yucatan Peninsula, Mexico. Vector Borne Zoonotic Dis 9: 243251.[Crossref] [Google Scholar]
  18. Dumonteil E, Ferral J, Euan-García M, Chavez-Nuñez L, Ramirez-Sierra MJ, , 2009. Usefulness of community participation for the fine-scale monitoring of non-domiciliated triatomines. J Parasitol 95: 469471.[Crossref] [Google Scholar]
  19. Gourbière S, Dumonteil E, Rabinovich J, Minkoue R, Menu F, , 2008. Demographic and dispersal constraints for domestic infestation by non-domiciliated Chagas disease vectors in the Yucatan peninsula, Mexico. Am J Trop Med Hyg 78: 133139. [Google Scholar]
  20. Guzman-Tapia Y, Ramirez-Sierra MJ, Dumonteil E, , 2007. Urban infestation by Triatoma dimidiata in the city of Mérida, Yucatan, Mexico. Vector Borne Zoonotic Dis 7: 597606.[Crossref] [Google Scholar]
  21. Herber O, Kroeger A, , 2003. Pyrethroid-impregnated curtains for Chagas' disease control in Venezuela. Acta Trop 88: 3338.[Crossref] [Google Scholar]
  22. Ault SK, , 1994. Environmental management: a re-emerging vector control strategy. Am J Trop Med Hyg 50 (Suppl): 3549. [Google Scholar]
  23. Boischio A, Sanchez A, Orosz Z, Charron D, , 2009. Health and sustainable development: challenges and opportunities of ecosystem approaches in the prevention and control of dengue and Chagas disease. Cad Saude Publica 25 (Suppl 1): S149S154.[Crossref] [Google Scholar]
  24. Ellis BR, Wilcox BA, , 2009. The ecological dimensions of vector-borne disease research and control. Cad Saude Publica 25 (Suppl 1): S155S167.[Crossref] [Google Scholar]
  25. Zeledon R, Rojas JC, Urbina A, Cordero M, Gamboa SH, Lorosa ES, Alfaro S, , 2008. Ecological control of Triatoma dimidiata (Latreille, 1811): five years after a Costa Rican pilot project. Mem Inst Oswaldo Cruz 103: 619621.[Crossref] [Google Scholar]
  26. Monroy C, Bustamante DM, Pineda S, Rodas A, Castro X, Ayala V, Quinones J, Moguel B, , 2009. House improvements and community participation in the control of Triatoma dimidiata re-infestation in Jutiapa, Guatemala. Cad Saude Publica 25 (Suppl 1): S168S178.[Crossref] [Google Scholar]
  27. Dumonteil E, Gourbière S, , 2004. Prediction of Triatoma dimidiata vector abundance and infection rate: a risk map for Trypanosoma cruzi natural transmission in the Yucatan peninsula of Mexico. Am J Trop Med Hyg 70: 514519. [Google Scholar]
  28. Wood E, de Licastro SA, Casabe N, Picollo MI, Alzogaray R, Nicolas Zerba E, , 1999. A new tactic for Triatoma infestans control: fabrics impregnated with beta-cypermethrin. Rev Panam Salud Publica 6: 17.[Crossref] [Google Scholar]
  29. Yates A, N'Guessan R, Kaur H, Akogbeto M, Rowland M, , 2005. Evaluation of KO-Tab 1-2-3: a wash-resistant ‘dip-it-yourself’ insecticide formulation for long-lasting treatment of mosquito nets. Malar J 4: 52.[Crossref] [Google Scholar]
  30. Levy MZ, Bowman NM, Kawai V, Plotkin JB, Waller LA, Cabrera L, Steurer F, Seitz AE, Pinedo-Cancino VV, Cornejo del Carpio JG, Cordova Benzaquen E, McKenzie FE, Maguire JH, Gilman RH, Bern C, , 2009. Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots. Clin Infect Dis 48: 11041106.[Crossref] [Google Scholar]
  31. Ramirez-Sierra MJ, Herrera-Aguilar M, Gourbière S, Dumonteil E, , 2009. Patterns of house infestation dynamics by non-domiciliated Triatoma dimidiata reveal a spatial gradient of infestation in rural villages and potential insect manipulation by Trypanosoma cruzi . Trop Med Int Health (in press). doi:10.1111/j.1365-3156.2009.02422.x. [Google Scholar]
  32. Bell ML, Baker JR, , 2000. Comparison of greenhouse screening materials for excluding whitefly (Homoptera: Aleyrodidae) and thrips (Thysanoptera: Thripidae). J Econ Entomol 93: 800804.[Crossref] [Google Scholar]
  33. Wood BL, Beck LR, Lobitz BM, Bobo MR, , 2000. Education, outreach and the future of remote sensing in human health. Adv Parasitol 47: 331344.[Crossref] [Google Scholar]
  34. Zeledón R, Rojas JC, , 2006. Environmental management for the control of Triatoma dimidiata (Latreille, 1811), (Hemiptera: Reduviidae) in Costa Rica: a pilot project. Mem Inst Oswaldo Cruz 101: 379386.[Crossref] [Google Scholar]
  35. Rojas-De-Arias A, , 2001. Chagas disease prevention through improved housing using an ecosystem approach to health. Cad Saude Publica 17: 8997.[Crossref] [Google Scholar]
  36. Acevedo F, Godoy E, Schofield C, , 2000. Comparison of intervention strategies for control of Triatoma dimidiata in Nicaragua. Mem Inst Oswaldo Cruz 95: 867871.[Crossref] [Google Scholar]
  37. Vazquez-Prokopec GM, Spillmann C, Zaidenberg M, Kitron U, Gurtler RE, , 2009. Cost-effectiveness of Chagas disease vector control strategies in northwestern Argentina. PLoS Negl Trop Dis 3: e363.[Crossref] [Google Scholar]
  38. Rojas de Arias A, Ferro EA, Ferreira ME, Simancas LC, , 1999. Chagas disease vector control through different intervention modalities in endemic localities of Paraguay. Bull World Health Organ 77: 331339. [Google Scholar]
  39. Castillo-Riquelme M, Guhl F, Turriago B, Pinto N, Rosas F, Martinez MF, Fox-Rushby J, Davies C, Campbell-Lendrum D, , 2008. The costs of preventing and treating Chagas disease in Colombia. PLoS Negl Trop Dis 2: e336.[Crossref] [Google Scholar]
  40. Kroeger A, Ayala C, Medina Lara A, , 2002. Unit costs for house spraying and bednet impregnation with residual insecticides in Colombia: a management tool for the control of vector-borne disease. Ann Trop Med Parasitol 96: 405416.[Crossref] [Google Scholar]
  41. Diabate A, Chandre F, Rowland M, N'Guessan R, Duchon S, Dabire KR, Hougard JM, , 2006. The indoor use of plastic sheeting pre-impregnated with insecticide for control of malaria vectors. Trop Med Int Health 11: 597603.[Crossref] [Google Scholar]
  42. Sexton JD, , 1994. Impregnated bed nets for malaria control: biological success and social responsibility. Am J Trop Med Hyg 50: 7281. [Google Scholar]
  43. Beach RF, Ruebush TK, 2nd Sexton JD, Bright PL, Hightower AW, Breman JG, Mount DL, Oloo AJ, , 1993. Effectiveness of permethrin-impregnated bed nets and curtains for malaria control in a holoendemic area of western Kenya. Am J Trop Med Hyg 49: 290300. [Google Scholar]
  44. Kroeger A, Lenhart A, Ochoa M, Villegas E, Levy M, Alexander N, McCall PJ, , 2006. Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomized trials. BMJ 332: 12471252.[Crossref] [Google Scholar]

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  • Received : 03 Jul 2009
  • Accepted : 12 Oct 2009
  • Published online : 05 Jan 2010

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