Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The role of human Fcγ receptors (FcγR) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of FcγR genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific FcγRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated to a reduced risk for developing dengue hemorrhagic fever (DHF). Here, we investigated the role of this polymorphism in a very well-characterized group of Cuban individuals with antecedents of DHF, dengue fever (DF), or subclinical dengue infection. The HH131 genotype was significantly associated with dengue disease, either DF (* = 0.016; odds ratio = 4.425; 95% confidence interval = 1.10–20.52) or DHF ( = 0.00018; odds ratio = 10.56; 95% confidence interval = 2.33–54.64) with respect to the subclinical infection.


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  • Received : 23 Jun 2009
  • Accepted : 30 Dec 2009
  • Published online : 04 Jun 2010

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