1921
Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The role of human Fcγ receptors (FcγR) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of FcγR genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific FcγRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated to a reduced risk for developing dengue hemorrhagic fever (DHF). Here, we investigated the role of this polymorphism in a very well-characterized group of Cuban individuals with antecedents of DHF, dengue fever (DF), or subclinical dengue infection. The HH131 genotype was significantly associated with dengue disease, either DF (* = 0.016; odds ratio = 4.425; 95% confidence interval = 1.10–20.52) or DHF ( = 0.00018; odds ratio = 10.56; 95% confidence interval = 2.33–54.64) with respect to the subclinical infection.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.09-0353
2010-06-01
2017-09-23
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/6/1153.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0353&mimeType=html&fmt=ahah

References

  1. Byron E, Martina E, Koraka P, Albert D, Osterhaus ME, , 2009. Dengue virus pathogenesis: an integrated view. Clin Microbiol Rev 22: 564581.[Crossref]
  2. Sierra B, Alegre R, Perez AB, Garcia G, Sturn-Ramirez K, Guzmán MG, , 2007. HLA A, B and DRB1 allele frequencies in Cuban individuals with antecedents of Dengue 2 disease. Advantages of the Cuban population for HLA studies of dengue virus infection. Hum Immunol 68: 531540.[Crossref]
  3. Loke H, Bethell DB, Phuong CX, Dung M, Schneider J, White NJ, Day NP, Farrar J, Hill AV, , 2001. Strong HLA class I–restricted T cell responses in dengue hemorrhagic fever: a double-edged sword? J Infect Dis 184: 13691373.[Crossref]
  4. Chiewsilp P, Scott RM, Bhamarapravati N, , 1981. Histocompatibility antigens and dengue hemorrhagic fever. Am J Trop Med Hyg 30: 11001105.
  5. Lan NT, Kikuchi M, Huong VT, Ha do Q, Thuy TT, Tham VD, Tuan HM, Tuong VV, Nga CT, Van Dat T, Oyama T, Morita K, Yasunami M, Hirayama K, , 2008. Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome. PLoS Negl Trop Dis 2: e304.[Crossref]
  6. Loke H, Bethell D, Phuong CXT, Day N, White N, Farrar J, Hill A, , 2002. Susceptibility to dengue hemorrhagic fever in Vietnam: evidence of an association with variation in the vitamin D receptor and Fc ganma receptor IIa genes. Am J Trop Hyg 67: 102106.
  7. Sakuntabhai A, Turbpaiboon C, Casademont I, Chuansumrit A, Lowhnoo T, Kajaste-Rudnitski A, Kalayanarooj SM, Tangnararatchakit K, Tangthawornchaikul N, Vasanawathana S, Chaiyaratana W, Yenchitsomanus PT, Suriyaphol P, Avirutnan P, Chokephaibulkit K, Matsuda F, Yoksan S, Jacob Y, Lathrop GM, Malasit P, Despres P, Julier C, , 2005. A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet 37: 507513.[Crossref]
  8. Van de Winkel JGJ, Capel PJA, , 1993. Hman IgG Fc receptor heterogenicity: molecular aspects and clinical implications. Immunol Today 14: 215221.[Crossref]
  9. Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ, , 1991. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147: 13381343.
  10. Kimberly C, Altaf A, Lisa B, Steketee R, Bernard L, Ya Ping S, , 2004. Polymorphism of Fc receptor IIafor immunoglobulin G is associated with placental malaria in HIV-1–positive women in Western Kenya. J Infect Dis 190: 11921198.[Crossref]
  11. Guzman MG, Kouri G, , 2008. Dengue haemorrhagic fever integral hypothesis: confirming observations. Trans R Soc Trop Med Hyg 102: 522523.[Crossref]
  12. Libel M, , 2006. Brote de dengue en Cuba, 2006. Enfermedades infecciosas emergentes y reemergentes, Región de las Américas. Havana, Cuba: Organización Panamericana de la Salud.
  13. WHO, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Geneva: WHO, 2nd ed.
  14. Vazquez S, Valdes O, Pupo M, Delgado I, Alvarez M, Pelegrino JL, Guzman MG, , 2003. MAC-ELISA and ELISA inhibition methods for detection of antibodies after yellow fever vaccination. J Virol Methods 110: 179184.[Crossref]
  15. Vazquez S, Perez AB, Ruiz D, Rodriguez R, Pupo M, Calzada N, Gonzalez L, Gonzalez D, Castro O, Serrano T, Guzman MG, , 2005. Serological markers during dengue 3 primary and secondary infections. J Clin Virol 33: 132137.[Crossref]
  16. Bazilio AP, Viana VST, Toledo R, Woronik V, Bonfá E, Monteiro RC, , 2004. Fc ganma RIIa polymorphism: a susceptibility factor for inmune complex-mediated lupus nephritis in Brazilian patients. Nephrol Dial Transplant 19: 14271431.[Crossref]
  17. Cooke G, Aucan C, Walley AJ, Segal SG, Greenwood B, Hill AVS, , 2003. Association of Fc ganma receptor IIa (CD32) polymorphism with severe Malaria in West Africa. Am J Trop Hyg 69: 565568.
  18. Yee AM, Phan HM, Zuniga R, Salmon JE, Musher DM, , 2000. Association between FcgammaRIIa-R131 allotype and bacteremic pneumococcal pneumonia. Clin Infect Dis 30: 2528.[Crossref]
  19. Bossuyt X, Moens L, Van Hoeyveld E, Jeurissen A, Bogaert G, Sauer K, , 2007. Coexistence of (partial) immune defects and risk of recurrent respiratory infections. Clin Chem 53: 11241130.[Crossref]
  20. Koraka P, Suharti C, Setiati TE, Mairuhu AT, Van Gorp E, Hack CE, Juffrie M, Sutaryo J, Van Der Meer GM, Groen J, Osterhaus AD, , 2001. Kinetics of dengue virus-specific serum immunoglobulin classes and subclasses correlate with clinical outcome of infection. J Clin Microbiol 39: 43324338.[Crossref]
  21. van Sorge NM, van der Pol W-L, van de Winkel JGJ, , 2003. FcgrR polymorphisms: implications for function, disease susceptibility and immunotherapy. Tissue Antigens 61: 189202.[Crossref]
  22. García E, Rosales C, , 2002. Signal transduction during Fc receptor-mediated phagocytosis. J Leukoc Biol 72: 10921108.
  23. Israelsson E, Vafa M, Maiga B, Lysén A, Iriemenam NC, Dolo A, Doumbo OK, Troye-Blomberg M, Berzins K, , 2008. Differences in Fc gamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali. Malar J 15: 175.[Crossref]
  24. Forthal DN, Moog C, , 2009. Fc receptor-mediated antiviral antibodies. Current Opinion in HIV and AIDS 4: 388393.[Crossref]
  25. Moi ML, Lim CHK, Takasaki T, Kurane I, , 2010. Involvement of the Fcγ receptor IIA cytoplasmic domain in antibody dependent enhancement of dengue virus infection. J Gen Virol 91: 103111.[Crossref]
  26. Bruhns P, Iannascoli B, England P, Mancardi D, Fernández N, Jorieux S, Daeron M, , 2009. Specificity and affinity of human Fc gamma receptor and their polymorphic variants for human IgG subclasses. Blood 113: 37163725.[Crossref]
  27. García G, Rosado I, Sierra B, Pérez AB, Hirayama K, Guzmán MG, , 2008. Variantes genotípicas del receptor de baja afinidad Fcγ II a en la población cubana de Ciudad de la Habana. Revista Cubana de Genética Comunitaria 2: 4651.
  28. Lehrnbecher T, Foster CB, Zhu S, Leitman SF, Goldin LR, Huppi K, Chanock SJ, , 1999. Variant genotypes of the low affinity Fcg receptors in two control populations and a review of low affinity receptor polymorphisms in control and disease population. Blood 94: 42204232.
  29. Halstead S, , 2006. Dengue in Americas and Southeast Asia: do they differ? Rev Panam Salud Publica 20: 407415.[Crossref]
  30. Sierra BC, Kourí G, Guzmán MG, , 2007. Race: a risk factor for dengue hemorrhagic fever. Arch Virol 152: 533542.[Crossref]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0353
Loading
/content/journals/10.4269/ajtmh.2010.09-0353
Loading

Data & Media loading...

  • Received : 23 Jun 2009
  • Accepted : 30 Dec 2009

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error