1921
Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

chronic infections are usually asymptomatic and underestimated. We used direct fresh stool examination, Ritchie's method, and agar plate culture for diagnosis in patients with eosinophilia and previous residence in endemic areas. The frequency of strongyloidosis detected among these patients was high: 21 of 42 were positive. Among them, 10 were positive only by agar plate culture. After ivermectin treatment, patients resulted negative for parasitological tests and reduced their eosinophil counts. Half of the submitted patients that were followed 4–12 months after treatment remained negative without eosinophilia, except one who showed an eosinophil ascending curve before reappearance of larvae in stools. The high frequency of strongyloidosis found in this group emphasizes the relevance of including this parasitosis among differential diagnosis in patients with eosinophilia and past risk of infection to prevent disseminated infections secondary to corticoid therapy.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2010.09-0332
2010-06-04
2019-12-13
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/6/1088.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0332&mimeType=html&fmt=ahah

References

  1. Brigandi RA, Rotman HL, Nolan TJ, Schad GA, Abraham D, , 1997. Chronicity in Strongyloides stercoralis infections: dichotomy of the protective inmune response to infective and autoinfective larvae in a mouse model. Am J Trop Med Hyg 56: 640646. [Google Scholar]
  2. Concha R, Harrington W, Jr Rogers AI, , 2005. Intestinal strongyloidiasis: recognition, management and determinants of outcome. J Clin Gastroenterol 39: 203211.[Crossref] [Google Scholar]
  3. Vadlamudi RS, Chi DS, Krishnaswamy G, , 2006. Intestinal strongyloidiasis and hyperinfection syndrome. Clin Mol Allergy 30: 48. [Google Scholar]
  4. Segarra-Newnham M, , 2007. Manifestations, diagnosis, and treatment of Strongyloides stercoralis infection. Ann Pharmacother 41: 19922001.[Crossref] [Google Scholar]
  5. Marcos LA, Terashima A, Dupont HL, Gotuzzo E, , 2008. Strongyloides hyperinfection syndrome: an emerging global infectious disease. Trans R Soc Trop Med Hyg 102: 314318.[Crossref] [Google Scholar]
  6. Keiser PB, Nutman TB, , 2004. Strongyloides stercoralis in the inmunocompromised population. Rev Clin Microbiol Rev 17: 208217.[Crossref] [Google Scholar]
  7. Al-Hasan MN, McCormick M, Ribes JA, , 2007. Invasive enteric infections in hospitalized patients with underlying strongyloidiasis. Am J Clin Pathol 128: 622627.[Crossref] [Google Scholar]
  8. Siddiqui AA, Berk SL, , 2001. Diagnosis of Strongyloides stercoralis infection. Clin Infect Dis 33: 10401047.[Crossref] [Google Scholar]
  9. Lim S, Katz K, Krajden S, Fuksa M, Keystone JS, Kain KC, , 2004. Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. CMAJ 171: 479484.[Crossref] [Google Scholar]
  10. Intapan PM, Maleewong W, Wongsaroj T, Singthong S, Morakote N, , 2005. Comparison of the quantitative formalin ethyl acetate concentration technique and agar plate culture for diagnosis of human strongyloidiasis. J Clin Microbiol 43: 19321933.[Crossref] [Google Scholar]
  11. Salazar SA, Gutierrez C, Berk SL, , 1995. Value of the agar plate method for the diagnosis of intestinal strongyloidiasis. Diagn Microbiol Infect Dis 23: 141145.[Crossref] [Google Scholar]
  12. De Kamisky RG, , 1993. Evaluation of three methods for laboratory diagnosis of Strongyloides stercoralis infection. J Parasitol 79: 277280.[Crossref] [Google Scholar]
  13. Jongwutiwes S, Charoenkorn M, Sitthichareonchai P, Akaraborvorn P, Putaporntip C, , 1999. Increased sensitivity of routine laboratory detection of Strongyloides stercoralis and hookworm by agar-plate culture. Trans R Soc Trop Med Hyg 93: 398400.[Crossref] [Google Scholar]
  14. Hirata T, Nakamura H, Kinjo N, Hokama A, Kinjo F, Yamane N, Fujita J, , 2007. Increased detection rate of Strongyloides stercoralis by repeated stool examinations using the agar plate culture method. Am J Trop Med Hyg 77: 683684. [Google Scholar]
  15. Sato Y, Kobayashi J, Toma H, Shiroma Y, , 1995. Efficacy of stool examination for detection of Strongyloides infection. Am J Trop Med Hyg 53: 248250. [Google Scholar]
  16. van Doorn HR, Koelewijn R, Hofwegen H, Gilis H, Wetsteyn JC, Wismans PJ, Sarfati C, Vervoort T, Van Gool T, , 2007. Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans. J Clin Microbiol 45: 438442.[Crossref] [Google Scholar]
  17. Centers for Disease Control and Prevention, 2009. Diagnostic findings: strongyloidiasis antibody detection. Available at: http:/www.dpd.cdc.gov/dpdx/html/frames/S-Z/Strongyloidiasis/. Accessed August 28, 2009. [Google Scholar]
  18. Checkley AM, Chiodini PL, Dockrell DH, Bates I, Thwaites GE, Booth HL, Brown M, Wrigght SG, Grant AD, Mabey DC, Whitty C, Sanderson F, , British Infection Society and Hospital for Tropical Diseases, 2010. Eosinophilia in returning travelers and migrants from the tropics: UK recommendations for investigation and initial management. J Infect 60: 120.[Crossref] [Google Scholar]
  19. Ramanathan R, Nutman T, , 2008. Strongyloides stercoralis infection in the immunocompromised host. Curr Infect Dis Rep 10: 105110.[Crossref] [Google Scholar]
  20. González Cappa SM, Paulin P, , 1997. Microbiología clínica. Diagnóstico Parasitológico. Argentina: Asociación Argentina de Microbiología, Colegio de Bioquímicos de la Provincia de Entre Ríos, Facultad de Bioquímica y Ciencias Biológicas. [Google Scholar]
  21. Garcia LS, , 2007. Diagnosis Medical Parasitology. Fifth edition. Washington, DC: ASM Press. [Google Scholar]
  22. Loutfy M, Wilson M, Keystone J, Kain K, , 2002. Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area. Am J Trop Med Hyg 66: 749762. [Google Scholar]
  23. Olsen A, van Lieshout L, Marti H, Polderman T, Polman K, Steinmann P, Stothard R, Thybo S, Verweij JJ, Magnussen P, , 2009. Strongyloidiasis–the most neglected of the neglected tropical diseases? Trans R Soc Trop Med Hyg 103: 967972.[Crossref] [Google Scholar]
  24. Genta RM, , 1992. Dysregulation of strongyloidiasis: a new hypothesis. Clin Microbiol Rev 5: 345355.[Crossref] [Google Scholar]
  25. Neva FA, , 1986. Biology and immunology of human strongyloidiasis. J Infect Dis 153: 397406.[Crossref] [Google Scholar]
  26. Mansfield LS, Niamatali S, Bhopale V, Volk S, Smith G, Lok JB, Genta RM, Schad GA, , 1996. Strongyloides stercoralis: maintenance of exceedingly chronic infections. Am J Trop Med Hyg 55: 617624. [Google Scholar]
  27. Boulware DR, Stauffer WM, Hendel-Paterson BR, Rocha JL, Seet RC, Summer AP, Nield LS, Supparatpinyo K, Chaiwarith R, Walker PF, , 2007. Maltreatment of Strongyloides infection: case series and worldwide physicians-in-training survey. Am J Med 120: 545.e1545.e8.[Crossref] [Google Scholar]
  28. Igual-Adell R, Oltra-Alcaraz C, Soler-Company E, Sánchez-Sánchez P, Matogo-Oyana J, Rodríguez-Calabuig D, , 2004. Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis. Expert Opin Pharmacother 5: 26152619.[Crossref] [Google Scholar]
  29. Intapan P, Prasongdee T, Laummaunwai P, Sawanyawisuth K, Singthong S, Maleewong W, , 2006. A modified filter paper culture technique for screening of Strongyloides stercoralis ivermectin sensitivity in clinical specimens. Am J Trop Med Hyg 75: 563564. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0332
Loading
/content/journals/10.4269/ajtmh.2010.09-0332
Loading

Data & Media loading...

  • Received : 16 Jun 2009
  • Accepted : 21 Feb 2010
  • Published online : 04 Jun 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error