1921
Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Infection rate is an estimate of the prevalence of arbovirus infection in a mosquito population. It is assumed that when infection rate increases, the risk of arbovirus transmission to humans and animals also increases. We examined some of the factors that can invalidate this assumption. First, we used a model to illustrate how the proportion of mosquitoes capable of virus transmission, or infectious, is not a constant fraction of the number of infected mosquitoes. Thus, infection rate is not always a straightforward indicator of risk. Second, we used a model that simulated the process of mosquito sampling, pooling, and virus testing and found that mosquito infection rates commonly underestimate the prevalence of arbovirus infection in a mosquito population. Infection rate should always be used in conjunction with other surveillance indicators (mosquito population size, age structure, weather) and historical baseline data when assessing the risk of arbovirus transmission.

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References

  1. Eldridge BF, Scott TW, Day JF, Tabachnick WJ, Eldridge BF, Edman JD, , 2004. Arbovirus diseases. , eds. Medical Entomology. Dordrecht, The Netherlands: Kluwer Academic Publishers, 415460.[Crossref] [Google Scholar]
  2. Moore CG, McLean RG, Mitchell CJ, Nasci RS, Tsai TF, Calisher CH, Marfin AA, Moore PS, Gubler DJ, , 1993. Guidelines for Arbovirus Surveillance Programs in the United States. Fort Collins, CO: Centers for Disease Control and Prevention. [Google Scholar]
  3. Kyle JL, Harris E, , 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 7192.[Crossref] [Google Scholar]
  4. Chiang CL, Reeves WC, , 1962. Statistical estimation of virus infection rates in mosquito vector populations. Am J Hyg 75: 377391. [Google Scholar]
  5. Dohm DJ, O'Guinn ML, Turell MJ, , 2002. Effect of environmental temperature on the ability of Culex pipiens (Diptera: Culicidae) to transmit West Nile virus. J Med Entomol 39: 221225.[Crossref] [Google Scholar]
  6. Richards SL, Mores CN, Lord CC, Tabachnick WJ, , 2007. Impact of extrinsic incubation temperature and virus exposure on vector competence of Culex pipiens quinquefasciatus Say (Diptera: Culicidae) for West Nile virus. Vector Borne Zoonotic Dis 4: 629636.[Crossref] [Google Scholar]
  7. Turell MJ, O'Guinn M, Oliver J, , 2000. Potential for New York mosquitoes to transmit West Nile virus. Am J Trop Med Hyg 62: 413414. [Google Scholar]
  8. Turell MJ, O'Guinn M, Dohm DJ, Jones JW, , 2001. Vector competence of North American mosquitoes (Diptera: Culicidae) for West Nile virus. J Med Entomol 38: 130134.[Crossref] [Google Scholar]
  9. Kramer D, Hardy JL, Presser SB, , 1983. Effect of temperature of extrinsic incubation on the vector competence of Culex tarsalis for western equine encephalomyelitis virus. Am J Trop Med Hyg 32: 11301139. [Google Scholar]
  10. Reisen WK, Meyer RP, Presser SB, Hardy JL, , 1993. Effect of temperature on the transmission of western equine encephalomyelitis and St. Louis encephalitis viruses by Culex tarsalis (Diptera: Culicidae). J Med Entomol 30: 151160.[Crossref] [Google Scholar]
  11. Meyer RP, Hardy JL, Reisen WK, , 1990. Diel changes in adult mosquito microhabitat temperatures and their relationship to the extrinsic incubation of arboviruses in mosquitoes in Kern County, California. J Med Entomol 27: 607614.[Crossref] [Google Scholar]
  12. Cowling DW, Gardner IA, Johnson WO, , 1999. Comparison of methods for estimation of individual-level prevalence based on pooled samples. Prev Vet Med 39: 211225.[Crossref] [Google Scholar]
  13. Ryan J, Dave K, Emmerich E, Fernandez B, Turell M, Johnson J, Gottfried K, Burkhalter K, Kerst A, Hunt A, Wirtz R, Nasci R, , 2003. Wicking assays for the rapid detection of West Nile and St. Louis encephalitis viral antigens in mosquitoes (Diptera: Culicidae). J Med Entomol 40: 9599.[Crossref] [Google Scholar]
  14. Chiles RE, Green EN, Fang Y, Goddard L, Roth A, Reisen WK, Scott TW, , 2004. Blinded laboratory comparison of the in situ enzyme immunoassay, the VecTest wicking assay, and a reverse transcription-polymerase chain reaction assay to detect mosquitoes infected with West Nile and St. Louis encephalitis viruses. J Med Entomol 41: 539544.[Crossref] [Google Scholar]
  15. Reisen WK, Fang Y, Martinez VM, , 2006. Effects of temperature on the transmission of West Nile virus by Culex tarsalis (Diptera: Culicidae). J Med Entomol 43: 309317.[Crossref] [Google Scholar]
  16. Gu W, Lampman R, Novak RJ, , 2003. Problems in estimating mosquito infection rates using MIR. J Med Entomol 40: 595596.[Crossref] [Google Scholar]
  17. Gu W, Lampman R, Novak RJ, , 2004. Assessment of arbovirus vector infection rates using variable size pooling. Med Vet Entomol 18: 200204.[Crossref] [Google Scholar]
  18. Walter SD, Hildreth SW, Beaty BJ, , 1980. Estimation of infection in populations of organisms using pools of variable size. Am J Epidemiol 112: 124128.[Crossref] [Google Scholar]
  19. Gu W, Unnasch TR, Katholi CR, Lampman R, Novak RJ, , 2008. Fundamental issues in mosquito surveillance for arboviral transmission. Trans R Soc Trop Med Hyg 102: 817822.[Crossref] [Google Scholar]
  20. Condotta SA, Hunter FF, Bidochka MJ, , 2004. West Nile virus infection rates in pooled and individual mosquito samples. Vector Borne Zoonotic Dis 4: 198203.[Crossref] [Google Scholar]
  21. Hachiya M, Osborne M, Stinson C, Werner BG, , 2007. Human eastern equine encephalitis in Massachusetts: predictive indicators from mosquitoes collected at 10 long term trap sites, 1979–2004. Am J Trop Med Hyg 76: 285292. [Google Scholar]
  22. Frank B, , 2004. Minimum infection rates. A tool for using mosquito trap catches to predict human disease incidence. Available at: http://www.azdhs.gov/phs/edc/edrp/es/pdf/billfrankminimuminfectionrates.pdf. Accessed August 2009. [Google Scholar]
  23. California Department of Public Health, 2009. California mosquito-borne virus surveillance and response plan. Available at: http://www.cdph.ca.gov/HealthInfo/discond/Documents/2009Mosq-SurvRespPlan.pdf. Accessed August 2009. [Google Scholar]
  24. Georgia Department of Community Health, 2009. Mosquito surveillance in Georgia. Available at: http://oasis.state.ga.us/Arboviral/index_mosquito.asp. Accessed August 2009. [Google Scholar]
  25. Day JF, Burgess J, Focks DA, Shroyer D, Rutledge CR, Day JF, Lord CC, O'Meara GF, Rey JR, Tabachnick WJ, , 2003. Surveillance issues. , eds. Florida Mosquito Control Response to the Challenge of West Nile Virus. Technical Bulletin of the Florida Mosquito Control Association No. 4. Fort Meyers, FL: Florida Mosquito Control Association, 28. [Google Scholar]
  26. Reisen WK, Milby MM, Reeves WC, Meyer RP, Bock ME, , 1983. Population ecology of Culex tarsalis (Diptera: Culicidae) in a foothill environment of Kern County, California: temporal changes in female relative abundance, reproductive status, and survivorship. Ann Entomol Soc Am 76: 800808.[Crossref] [Google Scholar]
  27. Gordon-Smith CE, , 1987. Factors influencing the transmission of western equine encephalomyelitis virus between its vertebrate maintenance hosts and from them to humans. Am J Trop Med Hyg 37 (Suppl.): 33S39S. [Google Scholar]
  28. Rua GL, Quinonez ML, Velez ID, Zuluaga JS, Rojas W, Poveda G, Ruiz D, , 2005. Laboratory estimation of the effects of increasing temperatures on the duration of gonotrophic cycle of Anopheles albimanus (Diptera: Culicidae). Mem Inst Oswaldo Cruz 100: 515520.[Crossref] [Google Scholar]
  29. Country Studies, 2008. California weather. Available at: http://countrystudies.us/united-states/weather/California/. Accessed August 2008. [Google Scholar]
  30. McHugh CP, , 1999. Survivorship and gonotrophic cycle length of Culex tarsalis (Diptera: Culicidae) near Sheridan, Placer County, California. J Med Entomol 27: 10271030.[Crossref] [Google Scholar]
  31. Chandra G, Seal B, Hati AK, , 1996. Age composition of the filarial vector Culex quinquefaciatus (Diptera: Culicidae) in Calcutta, India. Bull Entomol Res 86: 223226.[Crossref] [Google Scholar]
  32. Kolkata, cultural capital of India, 2008. Kolkata weather. Available at: www.kolkata.org.uk/weather-climate.html. Accessed August 2008. [Google Scholar]
  33. Elizondo-Quiroga A, Flores-Suarez A, Elizondo-Quiroga D, Ponce-Garcia G, Blitvich BJ, Contreras-Cordero JF, Gonzalez-Rojas JI, Mercado-Hernandez R, Beaty BJ, Fernandez-Sales I, , 2006. Gonotrophic cycle and survivorship of Culex quinquefasciatus (Diptera: Culicidae) using sticky ovitraps in Monterrey, northeastern Mexico. J Am Mosq Control Assoc 22: 1014.[Crossref] [Google Scholar]
  34. Reisen WK, , 1995. Effect of temperature on Culex tarsalis (Diptera: Culicidae) from the Coachella and San Joaquin valleys of California. J Med Entomol 32: 636645.[Crossref] [Google Scholar]
  35. Microsoft Corporation, 2007. Microsoft Office Excel. Redmond, WA: Microsoft Corporation. [Google Scholar]
  36. R Development Core Team, 2008. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. [Google Scholar]
  37. Hadfield TL, Turell M, Dempsey MP, David J, Park EJ, , 2001. Detection of West Nile virus in mosquitoes by RT-PCR. Mol Cell Probes 15: 147150.[Crossref] [Google Scholar]
  38. Rutledge CR, Day JF, Lord CC, Stark LM, Tabachnick WJ, , 2003. West Nile virus infection rates in Culex nigripalpus (Diptera: Culicidae) do not reflect transmission rates in Florida. J Med Entomol 40: 253258.[Crossref] [Google Scholar]
  39. Vitek CJ, Richards SL, Mores CN, Day JF, Lord CC, , 2008. Arbovirus transmission by Culex nigripalpus in Florida, 2005. J Med Entomol 45: 483493.[Crossref] [Google Scholar]
  40. Abel U, Schosser R, Süss J, , 1999. Estimating the prevalence of infectious agents using pooled samples: biometrical considerations. Zentralbl Bakteriol 289: 550563.[Crossref] [Google Scholar]
  41. Gu W, Novak RJ, , 2004. Detection probability of arbovirus infection in mosquito populations. Am J Trop Med Hyg 71: 636638. [Google Scholar]
  42. Katholi CR, Unnasch TR, , 2006. Important experimental parameters for determining infection rates in arthropod vectors using pool screening approaches. Am J Trop Med Hyg 74: 779785. [Google Scholar]
  43. Shroyer DA, , 1991. The 1990 Florida epidemic of St. Louis encephalitis: virus infection rates in Culex nigripalpus . J Fla Mosq Control Assoc 62: 6971. [Google Scholar]
  44. Day JF, , 2001. Predicting St. Louis encephalitis virus epidemics: lessons from recent, and not so recent, outbreaks. Ann Rev Entomol 46: 111138.[Crossref] [Google Scholar]
  45. Broom AK, Lindsay MDA, Johansen CA, Wright AE, Mckenzie JS, , 1995. Two possible mechanisms for survival and initiation of Murray Valley encephalitis virus activity in the Kimberley region of Western Australia. Am J Trop Med Hyg 53: 9599. [Google Scholar]
  46. Florida Department of Health, 2009. Surveillance and Control of Selected Mosquito-Borne Diseases in Florida. 2009 Guidebook. Tallahassee, FL: Division of Environmental Health. [Google Scholar]
  47. Ezenwa VO, Godsey MS, King RJ, Guptill SC, , 2006. Avian density and West Nile virus: testing associations between biodiversity and infectious disease risk. Proc Biol Soc 273: 109117.[Crossref] [Google Scholar]
  48. Kilpatrick AM, Kramer LD, Campbell SR, Alleyne O, Dobson AP, Daszak P, , 2005. West Nile virus risk assessment and the bridge vector paradigm. Emerg Infect Dis 11: 425429.[Crossref] [Google Scholar]
  49. Gujral IB, Zielinski-Gutierrez EC, LeBailly A, Nasci R, , 2007. Behavioral risk for West Nile virus disease, northern Colorado, 2003. Emerg Infect Dis 13: 419425.[Crossref] [Google Scholar]
  50. Kilpatrick AM, Meola MA, Moudy RM, Kramer LD, , 2008. Temperature, viral genetics, and the transmission of West Nile virus by Culex pipiens mosquitoes. PLoS Pathog 4: e1000092.[Crossref] [Google Scholar]
  51. Alto BW, Lounibos LP, Higgs S, Juliano SA, , 2005. Larval competition differentially affects arbovirus infection in Aedes mosquitoes. Ecology 86: 32793288.[Crossref] [Google Scholar]
  52. Nasci RS, Mitchell CJ, , 1996. Arbovirus titer variation in field-collected mosquitoes. J Am Mosq Control Assoc 12: 167171. [Google Scholar]
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  • Received : 12 Jun 2009
  • Accepted : 08 Feb 2010

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