1921
Volume 82, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The new recommendations to prevent malaria in pregnant women have recently been implemented in Gabon. There is little information on the pregnancy indicators that are useful for their evaluation. A cross-sectional study for the assessment of the prevalence of peripheral, placental, and cord malaria and anemia among delivering women was performed at the largest public hospital of Gabon. Malaria prevalence was 34.4%, 53.6%, and 18.2% for maternal peripheral, placental, and cord blood respectively, with no difference between primigravidae and multigravidae. Submicroscopic infections were frequent and concerned all the positive cord samples. Maternal peripheral, late placental, and cord infections were all associated with a reduced mean birth weight in primigravidae ( = 0.02). Anemia prevalence was 53%, low birth rate was 13%, and prematurity was 25%. The use of intermittent preventive treatment with sulfadoxine-pyrimethamine (greater than or equal to one dose) combined with bed net was associated with a reduction in infection only in multigravidae and with a reduced risk of maternal anemia.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2010.09-0267
2010-02-05
2019-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/2/202.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0267&mimeType=html&fmt=ahah

References

  1. Fried M, Duffy PE, , 1998. Maternal malaria and parasite adhesion. J Mol Med 76: 162171.[Crossref] [Google Scholar]
  2. Uneke CJ, , 2007. Impact of placental Plasmodium falciparum malaria on pregnancy and perinatal outcome in sub-Saharan Africa. II: effects of placental malaria on perinatal outcome; malaria and HIV. Yale J Biol Med 80: 95103. [Google Scholar]
  3. Steketee RW, Wirima JJ, Hightower AW, Slutsker L, Heymann DL, Breman JG, , 1996. The effect of malaria and malaria prevention in pregnancy on offspring birthweight, prematurity, and intrauterine growth retardation in rural Malawi. Am J Trop Med Hyg 55: 3341. [Google Scholar]
  4. World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the African Region. Brazzaville, Republic of Congo: WHO. [Google Scholar]
  5. Parise ME, Ayisi JG, Nahlen BL, Schultz LJ, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW, , 1998. Efficacy of sulfadoxine–pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59: 813822. [Google Scholar]
  6. Rogerson SJ, Chaluluka E, Kanjala M, Mkundika P, Mhango C, Molyneux ME, , 2000. Intermittent sulfadoxine-pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997–99. Trans R Soc Trop Med Hyg 94: 549553.[Crossref] [Google Scholar]
  7. Verhoeff FH, Brabin BJ, Chimsuku L, Kazembe P, Russell WB, Broadhead RL, , 1998. An evaluation of the effects of intermittent sulfadoxine-pyrimethamine treatment in pregnancy on parasite clearance and risk of low birthweight in rural Malawi. Ann Trop Med Parasitol 92: 141150.[Crossref] [Google Scholar]
  8. de Santé Ministère, , 2003. Rapport de l’atelier national de consensus. Traitement Préventif Intermittent contre le Paludisme chez la Femme Enceinte. Programme National de Lutte Contre le Paludisme, Libreville, Gabon. [Google Scholar]
  9. Ramharter M, Schuster K, Bouyou-Akotet MK, Adegnika AA, Schmits K, Mombo-Ngoma G, Agnandji ST, Nemeth J, Afène SN, Issifou S, Onnas IN, Kombila M, Kremsner PG, , 2007. Malaria in pregnancy before and after the implementation of a national IPTp program in Gabon. Am J Trop Med Hyg 77: 418422. [Google Scholar]
  10. Nsimba B, Guiyedi V, Mabika-Mamfoumbi M, Mourou-Mbina JR, Ngoungou E, Bouyou-Akotet M, Loembet R, Durand R, Le Bras J, Kombila M, , 2008. Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: a randomized trial to guide national policy. Malar J 7: 3138.[Crossref] [Google Scholar]
  11. Planche T, Krishna S, Kombila M, Engel K, Faucher JF, Ngou-Milama E, Kremsner PG, , 2001. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 65: 599602. [Google Scholar]
  12. Ntoumi F, Contamin H, Rogier C, Bonnefoy S, Trape JF, Mercereau-Puijalon O, , 1995. Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections. Am J Trop Med Hyg 52: 8188. [Google Scholar]
  13. Mockenhaupt FP, Bedu-Addo G, von Gaertner C, Boyé R, Fricke K, Hannibal I, Karakaya F, Schaller M, Ulmen U, Acquah PA, Dietz E, Eggelte TA, Bienzle U, , 2006. Detection and clinical manifestation of placental malaria in southern Ghana. Malar J 5: 119128.[Crossref] [Google Scholar]
  14. Mayor A, Serra-Casas E, Bardají A, Sanz S, Puyol L, Cisteró P, Sigauque B, Mandomando I, Aponte JJ, Alonso PL, Menéndez C, , 2009. Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women. Malar J 8: 918.[Crossref] [Google Scholar]
  15. Färnert A, Arez AP, Babiker HA, Beck HP, Benito A, Björkman A, Bruce MC, Conway DJ, Day KP, Henning L, Mercereau-Puijalon O, Ranford-Cartwright LC, Rubio JM, Snounou G, Walliker D, Zwetyenga J, do Rosario VE, , 2001. Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study. Trans R Soc Trop Med Hyg 95: 225232.[Crossref] [Google Scholar]
  16. Jarra W, Snounou G, , 1998. Only viable parasites are detected by PCR following clearance of rodent malarial infections by drug treatment or immune responses. Infect Immun 66: 37833787. [Google Scholar]
  17. Beny A, Fabre R, Benoi-Vical F, Cassaing S, Magnaval JF, , 2005. Contribution of PCR-based methods to diagnosis and management of imported malaria. Med Trop 65: 176183. [Google Scholar]
  18. Coleman RE, Sattabongkot J, Promstaporm S, Maneechai N, Tippayachai B, Kengluecha A, Rachapaew N, Zollner G, Miller RS, Vaughan JA, Thimasarn K, Khuntirat B, , 2006. Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand. Malar J 5: 121127.[Crossref] [Google Scholar]
  19. Nicastri E, Bevilacqua N, Sañé Schepisi M, Paglia MG, Meschi S, Ame SM, Mohamed JA, Mangi S, Fumakule R, Di Caro A, Capobianchi MR, Kitua A, Molteni F, Racalbuto V, Ippolito G, , 2009. Accuracy of malaria diagnosis by microscopy, rapid diagnostic test, and PCR methods and evidence of antimalarial overprescription in non-severe febrile patients in two Tanzanian hospitals. Am J Trop Med Hyg 80: 712717. [Google Scholar]
  20. Mockenhaupt FP, Ulmen U, von Gaertner C, Bedu-Addo G, Bienzle U, , 2002. Diagnosis of placental malaria. J Clin Microbiol 40: 306308.[Crossref] [Google Scholar]
  21. Bouyou-Akotet MK, Ionete-Collard DE, Mabika-Manfoumbi M, Kendjo E, Matsiegui PB, Mavoungou E, Kombila M, , 2003. Prevalence of Plasmodium falciparum infection in pregnant women in Gabon. Malar J 2: 1824.[Crossref] [Google Scholar]
  22. Adegnika AA, Verweij JJ, Agnandji ST, Chai SK, Breitling LP, Ramharter M, Frolich M, Issifou S, Kremsner PG, Yazdanbakhsh M, , 2006. Microscopic and sub-microscopic Plasmodium falciparum infection, but not inflammation caused by infection, is associated with low birth weight. Am J Trop Med Hyg 75: 798803. [Google Scholar]
  23. Rogerson SJ, Mkundika P, Kanjala MK, , 2003. Diagnosis of Plasmodium falciparum malaria at delivery: comparison of blood film preparation methods and of blood films with histology. J Clin Microbiol 41:1370-1374.[Crossref] [Google Scholar]
  24. Malhotra I, Mungai P, Muchiri E, Kwiek JJ, Meshnick SR, King CL, , 2006. Umbilical cord-blood infections with Plasmodium falciparum malaria are acquired antenatally in Kenya. J Infect Dis 194: 176183.[Crossref] [Google Scholar]
  25. Gies S, Coulibaly SO, Ouattara FT, D’Alessandro U, , 2009. Individual efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine in primi- and secundigravidae in rural Burkina Faso: impact on parasitaemia, anaemia and birth weight. Trop Med Int Health 14: 174182.[Crossref] [Google Scholar]
  26. Njagi JK, Magnussen P, Estambale B, Ouma J, Mugo B, , 2003. Prevention of anaemia in pregnancy using insecticide-treated bednets and sulfadoxine-pyrimethamine in a highly malarious area of Kenya: a randomized controlled trial. Trans R Soc Trop Med Hyg 97: 277282.[Crossref] [Google Scholar]
  27. Menéndez C, Bardají A, Sigauque B, Romagosa C, Sanz S, Serra-Casas E, Macete E, Berenguera A, David C, Dobaño C, Naniche D, Mayor A, Ordi J, Mandomando I, Aponte JJ, Mabunda S, Alonso PL, , 2008. A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic. Plos One 3: 19.[Crossref] [Google Scholar]
  28. Sirima SB, Cotte AH, Konaté A, Moran AC, Asamoa K, Bougouma EC, Diarra A, Ouédraogo A, Parise ME, Newman RD, , 2006. Malaria prevention during pregnancy: assessing the disease burden one year after implementing a program of intermittent preventive treatment in Koupela District, Burkina Faso. Am J Trop Med Hyg 75: 205211. [Google Scholar]
  29. Hommerich L, von Oertzen C, Bedu-Addo G, Holmberg V, Acquah PA, Eggelte TA, Bienzle U, Mockenhaupt FP, , 2007. Decline of placental malaria in southern Ghana after the implementation of intermittent preventive treatment in pregnancy. Malar J 6: 144151.[Crossref] [Google Scholar]
  30. Mbonye AK, Bygbjerg I, Magnussen P, , 2008. Intermittent preventive treatment of malaria in pregnancy: a community-based delivery system and its effect on parasitemia, anemia and low birth weight in Uganda. Int J Infect Dis 12: 2229.[Crossref] [Google Scholar]
  31. Mbaye A, Richardson K, Balajo B, Dunyo S, Shulman C, Milligan P, Greenwood B, Walraven G, , 2006. A randomized, placebo-controlled trial of intermittent preventive treatment with sulphadoxine-pyrimethamine in Gambian multigravidae. Trop Med Int Health 11: 9921002.[Crossref] [Google Scholar]
  32. Kabanywanyi AM, Macarthur JR, Stolk WA, Habbema JD, Mshinda H, Bloland PB, Abdulla S, Kachur SP, , 2008. Malaria in pregnant women in an area with sustained high coverage of insecticide-treated bed nets. Malar J 7: 133.[Crossref] [Google Scholar]
  33. Msyamboza K, Senga E, Tetteh-Ashong E, Kazembe P, Brabin BJ, , 2007. Estimation of effectiveness of interventions for malaria control in pregnancy using the screening method. Int J Epidemiol 36: 406411.[Crossref] [Google Scholar]
  34. van Eijk AM, Blokland IE, Slutsker L, Odhiambo F, Ayisi JG, Bles HM, Rosen DH, Adazu K, Lindblade KA, , 2005. Use of intermittent preventive treatment for malaria in pregnancy in a rural area of western Kenya with high coverage of insecticide-treated bed nets. Trop Med Int Health 10: 11341140.[Crossref] [Google Scholar]
  35. Falade CO, Yusuf BO, Fadero FF, Mokuolu OA, Hamer DH, Salako LA, , 2007. Intermittent preventive treatment with sulphadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria. Malar J 6: 8897.[Crossref] [Google Scholar]
  36. Akum AE, Kuoh AJ, Minang JT, Achimbom BM, Ahmadou MJ, Troye-Blomberg M, , 2005. The effect of maternal, umbilical cord and placental malaria parasitaemia on the birthweight of newborns from South-western Cameroon. Acta Paediatr 94: 917923.[Crossref] [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0267
Loading
/content/journals/10.4269/ajtmh.2010.09-0267
Loading

Data & Media loading...

  • Received : 19 May 2009
  • Accepted : 25 Oct 2009
  • Published online : 05 Feb 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error