Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment of uncomplicated malaria in children. In each arm, 160 patients were assigned to receive either AS + MQ or AL with 28 days follow-up. The adequate clinical and parasitological response at Day 28 for per protocol analysis was after polymerase chain reaction correction, 100% for AS + MQ and 96.8% for AL. In the intention-to-treat analysis, the respective cure rates were 96.2% for AS + MQ and 93.7% for AL. No serious adverse events (AEs) were reported. The most frequent AE was vomiting, 30% in AS + MQ arm and 36% in AL arm. No biological significant abnormal values related to the study drug have been reported. The new pediatric artesunate mefloquine formulated in granule fixed dose combination is well adapted to children in Africa.


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  1. World Health Organization, 2006 Guidelines for the Treatment of Malaria. Geneva: World Health Organization. WHO/HTM/RBM 2006.1108.
    [Google Scholar]
  2. Massougbodji A, Kone M, Kinde-Gazard D, Same-Ekobo A, Cambon N, Mueller EA, 2002 A randomized, double-blind study on the efficacy and safety of a practical three-day regimen with artesunate and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa. Trans R Soc Trop Med Hyg 96: 655659.[Crossref]
    [Google Scholar]
  3. Agomo PU, Meremikwu MM, Watila IM, Omalu IJ, Odey FA, Oguche S, Ezeiru VI, Aina OO, 2008 Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria. Malar J 7: 172.
  4. Ndiaye JL, Faye B, Diouf A, Kuété T, Cisse M, Seck PA, Brasseur P, Same-Ekobo A, Lameyre V, Gaye O, 2008 Randomized, comparative study of the efficacy and safety of artesunate plus amodiaquine, administered as a single daily intake versus two daily intakes in the treatment of uncomplicated falciparum malaria. Malar J 7: 16.
  5. World Health Organization, 2000 Management of Severe Malaria: A Practical Handbook. Second Edition. Geneva: WHO.
    [Google Scholar]
  6. World Health Organization, 1999 Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO.
    [Google Scholar]
  7. World Health Organization, 2003 Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated Falciparum Malaria. Geneva: World Health Organization. WHO/HTM/RBM/2003.50.
    [Google Scholar]
  8. Faye B, Ndiaye JL, Dieng Y, Faye O, Gaye O, 2007 Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal. Malar J 6: 80.[Crossref]
    [Google Scholar]
  9. Sagara I, Dicko A, Djimde A, Guindo O, Kone M, Tolo Y, Thera MA, Sogoba M, Fofana M, Ouattara A, Sissoko M, Jansen HF, Doumbo OK, 2008 A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Mali. Am J Trop Med Hyg 79: 655661.
    [Google Scholar]
  10. Valecha N, Srivastava P, Mohanty SS, Mittra P, Sharma SK, Tyagi PK, Pradhan K, Dev V, Singh R, Dash AP, Sharma YD, 2009 Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India. Malar J 8: 107.[Crossref]
    [Google Scholar]
  11. Hutagalung R, Paiphun L, Ashley EA, McGready R, Brockman A, Thwai KL, Singhasivanon P, Jelinek T, White NJ, Nosten FH, 2005 A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand. Malar J 4: 46.[Crossref]
    [Google Scholar]
  12. Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, Mcgready R, ter Kuile F, Looaresuwan S, White NJ, 2000 Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356: 297302.[Crossref]
    [Google Scholar]

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  • Received : 16 May 2009
  • Accepted : 15 Sep 2009
  • Published online : 05 Jan 2010

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