1921
Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

In cerebral malaria, the binding of parasitized erythrocytes to the cerebral endothelium and the consequent angiogenic dysregulation play a key role in pathogenesis. Because vascular endothelial growth factor (VEGF) is widely regarded as a potent stimulator of angiogenesis, edema, inflammation, and vascular remodeling, the plasma levels of VEGF and the soluble form of the VEGF receptor (sVEGFR)-1 and -2 in uncomplicated malaria patients and healthy adults were measured by enzyme-linked immunosorbent assay (ELISA) to examine their roles in malaria. The results showed that VEGF and sVEGFR-2 levels were significantly elevated in malaria patients compared with healthy adults. Moreover, it was confirmed that malarial parasite antigens induced VEGF secretion from the human mast cell lines HMC-1 or KU812 cell. This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.

Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2010.09-0203
2010-01-05
2019-11-21
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/1/136.html?itemId=/content/journals/10.4269/ajtmh.2010.09-0203&mimeType=html&fmt=ahah

References

  1. Moorthy VS, Good MF, Hill AV, , 2004 Malaria vaccine developments. Lancet 363: 150156.[Crossref] [Google Scholar]
  2. Deininger MH, Winkler S, Kremsner PG, Meyermann R, Schluesener HJ, , 2003 Angiogenic proteins in brains of patients who died with cerebral malaria. J Neuroimmunol 142: 101111.[Crossref] [Google Scholar]
  3. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey AS, Dvorak HK, , 1983 Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983985.[Crossref] [Google Scholar]
  4. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N, , 1989 Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 13061309.[Crossref] [Google Scholar]
  5. Ferrara N, Houck K, Jakeman L, Leung DW, , 1992 Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13: 1832.[Crossref] [Google Scholar]
  6. Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY, , 2001 Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 276: 76147620.[Crossref] [Google Scholar]
  7. Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Geehan CS, Luster AD, Sayegh MH, Briscoe DM, , 2003 Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest 112: 16551665.[Crossref] [Google Scholar]
  8. Lucerna M, Mechtcheriakova D, Kadl A, Schabbauer G, Schafer R, Gruber F, Koshelnick Y, Muller HD, Issbrucker K, Clauss M, Binder BR, Hofer E, , 2003 NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. Biol Chem 278: 1143311440.[Crossref] [Google Scholar]
  9. Kuenen BC, Levi M, Meijers JC, Kakkar AK, van Hinsbergh VW, Kostense PJ, Pinedo HM, Hoekman K, , 2002 Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler Thromb Vasc Biol 22: 15001505.[Crossref] [Google Scholar]
  10. Harada M, Mitsuyama K, Yoshida H, Sakisaka S, Taniguchi E, Kawaguchi T, Ariyoshi M, Saiki T, Sakamoto M, Nagata K, Sata M, Matsuo K, Tanikawa K, , 1998 Vascular endothelial growth factor in patients with rheumatoid arthritis. Scand J Rheumatol 27: 377380.[Crossref] [Google Scholar]
  11. Taha Y, Raab Y, Larsson A, Carlson M, Loof L, Gerdin B, Thorn M, , 2004 Vascular endothelial growth factor (VEGF)–a possible mediator of inflammation and mucosal permeability in patients with collagenous colitis. Dig Dis Sci 49: 109115.[Crossref] [Google Scholar]
  12. Boesiger J, Tsai M, Maurer M, Yamaguchi M, Brown LF, Claffey KP, Dvorak HF, Galli SJ, , 1998 Mast cells can secrete vascular permeability factor/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of Fcɛreceptor I expression. J Exp Med 21: 11351145.[Crossref] [Google Scholar]
  13. Grützkau A, Krüger-Krasagakes S, Baumeister H, Schwarz C, Kögel H, Welker P, Lippert U, Henz BM, Möller A, , 1998 Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206. Mol Biol Cell 9: 875884.[Crossref] [Google Scholar]
  14. Marshall JS, Bienenstock J, , 1994 The role of mast cells in inflammatory reactions of the airways, skin, and intestine. Curr Opin Immunol 6: 853859.[Crossref] [Google Scholar]
  15. Echtenacher B, Mannel DN, Hultner L, , 1996 Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381: 7577.[Crossref] [Google Scholar]
  16. Galli SJ, Maurer M, Lantz CS, , 1999 Mast cells as sentinels of innate immunity. Curr Opin Immunol 11: 5359.[Crossref] [Google Scholar]
  17. Malaviya R, Ikeda T, Ross E, Abraham SN, , 1996 Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature 381: 7780.[Crossref] [Google Scholar]
  18. Furuta T, Imajo-Ohmi S, Fukuda H, Kano S, Miyake K, Watanabe N, , 2008 Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin. Eur J Immunol 38: 13411350.[Crossref] [Google Scholar]
  19. Furuta T, Kikuchi T, Iwakura Y, Watanabe N, , 2006 Protective roles of mast cells and mast cell-derived TNF in murine malaria. J Immunol 177: 32943302.[Crossref] [Google Scholar]
  20. WHO, 1990 Severe and complicated malaria. Trans R Soc Trop Med Hyg 84: 165. [Google Scholar]
  21. Kishi K, , 1985 A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors. Leuk Res 9: 381390.[Crossref] [Google Scholar]
  22. Butterfield JH, Weiler D, Dewald G, Gleich GJ, , 1988 Establishment of an immature mast cell line from a patient with mast cell leukemia. Leuk Res 12: 345355.[Crossref] [Google Scholar]
  23. Kendall RL, Wang G, Thomas KA, , 1996 Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun 226: 324328.[Crossref] [Google Scholar]
  24. Muehlenbachs A, Mutabingwa TK, Edmonds S, Fried M, Duffy PE, , 2006 Hypertension and maternal-fetal conflict during placental malaria. PLoS Med 3: 214230.[Crossref] [Google Scholar]
  25. Maynard SE, Min J-Y, Merchan J, Lim K-H, Li J, Mondal S, Towia A, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA, , 2003 Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 111: 649658.[Crossref] [Google Scholar]
  26. Clark DE, Smith SK, He Y, Day KA, Licence DR, Crops AN, Lammoglia R, Charnock-Jones S, , 1998 A vascular endothelial growth factor antagonist is produced by the placenta and released into maternal circulation. Biol Reprod 59: 15401548.[Crossref] [Google Scholar]
  27. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Kai F, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Vikas P, Sukhatme VP, Karumanchi SA, , 2004 Circulating antigenic factors and the risk of preeclampsia. N Engl J Med 350: 672683.[Crossref] [Google Scholar]
  28. Watenberger J, Claessen-Weish L, Siegbahn A, Shibuya M, Heldin CH, , 1994 Different signal transduction properties of KDR and Flt-1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 2698826995. [Google Scholar]
  29. Jain V, Armah HB, Tongren JE, Ned RM, Wilson NO, Crawford S, Joel PK, Singh MP, Nagpal AC, Dash AP, Udhayakumar V, Singh N, Stiles JK, , 2008 Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar J 7: 8398.[Crossref] [Google Scholar]
  30. Marshall JS, , 2004 Mast-cell responses to pathogens. Nat Rev Immunol 4: 787799.[Crossref] [Google Scholar]
  31. Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Amina S, Woods AS, Gowda DC, , 2005 Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem 280: 86068616.[Crossref] [Google Scholar]
  32. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S, , 2005 Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 201: 1925.[Crossref] [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.09-0203
Loading
/content/journals/10.4269/ajtmh.2010.09-0203
Loading

Data & Media loading...

  • Received : 21 Apr 2009
  • Accepted : 12 Oct 2009
  • Published online : 05 Jan 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error