1921
Volume 82, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The merozoite surface protein 1 (MSP1) is the principal surface antigen of the blood stage form of the parasite. Antibodies recognizing MSP1 are frequently detected following infection, making this protein a significant component of malaria vaccines and diagnostic tests. Although the MSP1 gene sequence has been reported for and , this gene has not been identified for the other two major human-infectious species, and . MSP1 genes from these two species were isolated from Cameroon blood donor samples. The genes are similar in size to known MSP1 genes and encode proteins with interspecies conserved domains homologous to those identified in other species. Sequence and phylogenetic analysis of all available MSP1 amino acid sequences clearly shows that the and MSP1 sequences are truly unique within the genus and not simply or variants.

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  • Received : 13 Jan 2009
  • Accepted : 02 Mar 2010

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