1921
Volume 82, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

The planned upscaling of vector control strategies requires insight into the epidemiological consequences of vector resistance. Therefore, the pyrethroid and DDT resistance status of s.l. was assessed in Uganda from 2004 to 2006, and spatial and seasonal variations in knockdown resistance () frequencies were analyzed in terms of epidemiological significance. s.l. was DDT and pyrethroid resistant in central and eastern Uganda. The L1014S allele frequencies varied from 3% to 48% in s.s. Although the homozygous resistant genotype was the most prevalent genotype among survivors, the genotypes could not entirely explain the bioassay results. In the dry season, the frequency was significantly higher in -infected mosquitoes, indicating that mosquitoes bearing a mutation have a better adult survival, hence a higher likelihood of becoming infectious. This study showed that might have an epidemiological impact that could jeopardize the vector control strategies.

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2010-04-01
2017-09-26
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References

  1. President's Malaria Initiative Uganda, 2009. Malaria Operational Plan. Available at: http://www.fightingmalaria.gov/countries/profiles/uganda_profile.pdf. Accessed April 2009.
  2. Elissa N, Mouchet J, Riviere F, Meunier JY, Yao K, , 1993. Resistance of Anopheles gambiae s.s. to pyrethroids in Côte d'Ivoire. Ann Soc Belg Med Trop 73: 291294.
  3. WHO, 2005. Atlas of Insecticide Resistance in Malaria Vectors of the WHO African Region. Geneva: World Health Organization. Available at: http://www.afro.who.int/des/phe/publications/atlas_final_version.pdf. Accessed October 2005.
  4. Soderlund DM, Knipple DC, , 2003. The molecular biology of knockdown resistance to pyrethroid insecticides. Insect Biochem Mol Biol 33: 563577.[Crossref]
  5. Martinez-Torres D, Chandre F, Williamson MS, Darriet F, Bergé JB, Devonshire AL, Guillet P, Pasteur N, Pauron D, , 1998. Molecular characterization of pyrethroid knockdown resistance (kdr) in the major malaria vector Anopheles gambiae s.s. Insect Mol Biol 7: 179184.[Crossref]
  6. Ranson H, Jensen B, Vulule JM, Wang X, Hemingway J, Collins FH, , 2000. Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids. Insect Mol Biol 9: 491497.[Crossref]
  7. Darriet F, N'Guessan R, Koffi AA, Konan L, Doannio JM, Chandre F, Carnevale P, , 2000. Impact de la résistance aux pyréthrinoïdes sur l'efficacité des moustiquaires imprégnées dans la prévention du palidisme: résultats des essais en cases expérimentales avec la deltaméthrine SC. Bull Soc Pathol Exot 93: 131134.
  8. Mahama T, Desiree EJ, Pierre C, Fabrice C, , 2007. Effectiveness of permanet in Côte d'Ivoire rural areas and residual activity on a knockdown-resistant strain of Anopheles gambiae . J Med Entomol 44: 498502.
  9. Sharp BL, Ridl FC, Govender D, Kuklinski J, Kleinschmidt I, , 2007. Malaria vector control by indoor residual insecticide spraying on the tropical island of Bioko, Equatorial Guinea. Malar J 6: 52.[Crossref]
  10. Verhaeghen K, Van Bortel W, Roelants P, Backeljau T, Coosemans M, , 2006. Detection of the East and West African kdr mutation in Anopheles gambiae s.s. and An. arabiensis from Uganda using a new assay based on FRET/Melt Curve Analysis. Malar J 5: 16.[Crossref]
  11. Okello PE, Van Bortel W, Byaruhanga AM, Correwyn A, Roelants P, Talisuna A, D'Alessandro U, Coosemans M, , 2006. Variation in malaria transmission intensity in seven sites throughout Uganda. Am J Trop Med Hyg 75: 219225.
  12. Gillies MT, Coetzee M, , 1987. Supplement to the Anophelinae of Africa South of the Sahara. Publication no. 55. Johannesburg, South Africa: South African Institute for Medical Research.
  13. Collins FH, Mendez MA, Rasmussen MO, Mehaffey PC, Besansky NJ, Finnerty V, , 1987. A ribosomal RNA gene probe differentiates member species of the Anopheles gambiae complex. Am J Trop Med Hyg 37: 3741.
  14. Garros C, Koekemoer LL, Kamau L, Awolola TS, Van Bortel W, Coetzee M, Coosemans M, Manguin S, , 2004. Restriction fragment length polymorphism method for the identification of major African and Asian malaria vectors within the Anopheles funestus and An. minimus groups. Am J Trop Med Hyg 70: 260265.
  15. Scott JA, Brogdon WG, Collins FH, , 1993. Identification of single specimens of the Anopheles gambiae complex by the polymerase chain reaction. Am J Trop Med Hyg 49: 520529.
  16. Favia G, della Torre A, Bagayoko M, Lanfrancotti A, Sagnon N, Touré YT, Coluzzi M, , 1997. Molecular identification of sympatric chromosomal forms of Anopheles gambiae and further evidence of their reproductive isolation. Insect Mol Biol 6: 377383.[Crossref]
  17. WHO, 1998. Report of the WHO Informal Consultation. Test procedures for insecticide resistance monitoring in malaria vectors, bio-efficacy and persistence of insecticides on treated surfaces. Geneva: WHO.
  18. Goudet J, , 1995. FSTAT (version 1.2): a computer program to calculate F statistics. J Hered 86: 485486.[Crossref]
  19. Raymond M, Rousset F, , 1995. Genepop (version 1.2): a population genetics software for exact tests and ecumenicism. J Hered 86: 248249.[Crossref]
  20. Penilla PR, Rodriquez AD, Hemingway J, Torres JL, Arredonde-Jimenez JI, Rodriquez MH, , 1998. Resistance management strategies in malaria vector mosquito control. Baseline data for a large-scale field trial against Anopheles albimanus in Mexico. Med Vet Entomol 12: 217233.[Crossref]
  21. Stump AD, Atieli FK, Vulule JM, Besansky NJ, , 2004. Dynamics of the pyrethroid knockdown resistance allele in Western Kenyan populations of Anopheles gambiae in response to insecticide-treated bed nets trials. Am J Trop Med Hyg 70: 591596.
  22. Diabaté A, Baldet T, Chandre F, Akogbeto M, Guiguemde TR, Darriet F, Brengues C, Guillet P, Hemingway J, Small GJ, Hougard JM, , 2002. The role of agricultural use of insecticides in resistance to pyrethroids in Anopheles gambiae s.l. in Burkina Faso. Am J Trop Med Hyg 67: 617622.
  23. Awolola TS, Oduola AO, Oyewole IO, Obansa JB, Amajoh CN, Koekemoer LL, Coetzee M, , 2007. Dynamics of knockdown pyrethroid insecticide resistance alleles in a field population of Anopheles gambiae s.s. in southwestern Nigeria. J Vector Borne Dis 44: 181188.
  24. Protopopoff N, Verhaeghen K, Van Bortel W, Roelants P, Marcotty T, Baza D, D'Alessandro U, Coosemans M, , 2008. A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands. Trop Med Int Health 13: 14791487.[Crossref]
  25. Roush RT, Mckenzie JA, , 1987. Ecological genetics of insecticide and acaricide resistance. Annu Rev Entomol 32: 361380.[Crossref]
  26. Martinez-Torres D, Chevillon C, Brun-Barale A, Bergé JB, Pasteur N, Pauron D, , 1999. Voltage-dependent Na+ channels in pyrethroid-resistant Culex pipiens L mosquitoes. Pestic Sci 55: 10121020.[Crossref]
  27. Vulule JM, Beach RF, Atieli FK, McAllister JC, Brogdon WG, Roberts JM, Mwangi RW, Hawley WA, , 1999. Elevated oxidase and esterase levels associated with permethrin tolerance in Anopheles gambiae from Kenyan villages using permethrin-impregnated nets. Med Vet Entomol 13: 239244.[Crossref]
  28. Hougard JM, Corbel V, N'Guessan R, Darriet F, Chandre F, Akogbeto M, Baldet T, Guillet P, Carnevale P, Traore-Lamizana M, , 2003. Efficacy of mosquito nets treated with insecticide mixtures or mosaics against insecticide resistant Anopheles gambiae and Culex quinquefasciatus (Diptera: Culicidae) in Côte d'Ivoire. Bull Entomol Res 93: 491498.[Crossref]
  29. Asidi AN, N'Guessan R, Hutchinson RA, Traore-Lamizana M, Carnevale P, Curtis CF, , 2004. Experimental hut comparisons of nets treated with carbamate or pyrethroid insecticides, washed or unwashed, against pyrethroid-resistant mosquitoes. Med Vet Entomol 18: 134140.[Crossref]
  30. Henry MC, Assi SB, Rogier C, Sou-Yoyo J, Chandre F, Guillet P, Carnevale P, , 2005. Protective efficacy of lambda-cyhalothrin treated nets in Anopheles gambiae pyrethroid resistance areas of Côte d'Ivoire. Am J Trop Med Hyg 73: 859864.
  31. N'Guessan R, Corbel V, Akogbéto M, Rowland M, , 2007. Reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin. Emerg Infect Dis 13: 199206.[Crossref]
  32. Hargreaves K, Koekemoer LL, Brooke B, Hunt RH, Mthembu J, Coetzee M, , 2000. Anopheles funestus resistant to pyrethroid insecticides in South Africa. Med Vet Entomol 14: 181189.[Crossref]
  33. Etang J, Chandre F, Guillet P, Manga L, , 2004. Reduced bio-efficacy of permethrin EC impregnated bednets against an Anopheles gambiae strain with oxidase-based pyrethroid tolerance. Malar J 3: 46.[Crossref]
  34. John R, Ephraim T, Andrew A, , 2008. Reduced susceptibility to pyrethroid insecticide treated nets by the malaria vector Anopheles gambiae s.l. in western Uganda. Malar J 7: 92.[Crossref]
  35. Vais H, Williamson MS, Goodson SJ, Devonshire AL, Warmke JW, Usherwood PNR, Cohen CJ, , 2000. Activation of Drosophila sodium channels promotes modification by deltamethrin: reductions in affinity caused by knock-down resistance mutations. J Gen Physiol 115: 305318.[Crossref]
  36. Vais H, Atkinson S, Pluteanu F, Goodson SJ, Devonshire AL, Williamson MS, Usherwood PNR, , 2003. Mutations of the para sodium channel of Drosophila melanogaster identify putative binding sites for pyrethroids. Mol Pharmacol 64: 914922.[Crossref]
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  • Received : 22 Dec 2008
  • Accepted : 27 Nov 2009

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