Volume 82, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645



The planned upscaling of vector control strategies requires insight into the epidemiological consequences of vector resistance. Therefore, the pyrethroid and DDT resistance status of s.l. was assessed in Uganda from 2004 to 2006, and spatial and seasonal variations in knockdown resistance () frequencies were analyzed in terms of epidemiological significance. s.l. was DDT and pyrethroid resistant in central and eastern Uganda. The L1014S allele frequencies varied from 3% to 48% in s.s. Although the homozygous resistant genotype was the most prevalent genotype among survivors, the genotypes could not entirely explain the bioassay results. In the dry season, the frequency was significantly higher in -infected mosquitoes, indicating that mosquitoes bearing a mutation have a better adult survival, hence a higher likelihood of becoming infectious. This study showed that might have an epidemiological impact that could jeopardize the vector control strategies.


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  • Received : 22 Dec 2008
  • Accepted : 27 Nov 2009
  • Published online : 05 Apr 2010

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