1921
Volume 82, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A cross-sectional study was carried out in Água Comprida, MG, Brazil, a region previously endemic to Chagas disease whose vectorial transmission was interrupted around 20 year ago. A total of 998 individuals were examined for anti- antibodies. Seropositivity was observed in 255 subjects (25.5%), and 743 subjects were negative. Forty-one families with 5–80 individuals with similar environmental conditions were selected for familial analysis. In 15 families, seropositivity to was observed in > 50% of individuals. The segregation analysis confirmed family aggregation for the seropositivity to the . Heart commitment was the major clinical form observed, and in six families, > 50% of the individuals display cardiopathy that may be attributed to infection. Our results support the hypothesis that there is a family aggregation for the seropositivity but without the effect of one major gene.

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References

  1. Dessein A, Marquet S, Hillaire D, Rodrigues V, Abel L, 1996. Susceptibilité génétique aux infections parasitaires humaines: étude de la bilharziose. Annales de L’Institut Pasteur 7: 5962.[Crossref]
    [Google Scholar]
  2. Williams-Blangero S, Subedi J, Upadhayay RP, Manral DB, Rai DR, Jha B, Robinson ES, Blangero J, 1999. Genetic analysis of susceptibility to infection with Ascaris lumbricoides. Am J Trop Med Hyg 60: 921926.
    [Google Scholar]
  3. Segal S, Hill AVS, 2003. Genetic susceptibility to infectious disease. Trends Microbiol 11: 445448.[Crossref]
    [Google Scholar]
  4. Abel L, Dessein A, 1991. Predisposição genética a altos níveis de infecção em área endêmica de esquistossomose mansônica. Rev Soc Bras Med Trop 24: 13.[Crossref]
    [Google Scholar]
  5. Abel L, Demenais F, Prata A, Souza AE, Dessein A, 1991. Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni. Am J Hum Genet 48: 959970.
    [Google Scholar]
  6. Marquet S, Abel L, Hillaire D, Dessein H, Kalil J, Feingold J, Weissenbash J, Dessein AJ, 1996. Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31q33. Nat Genet 14: 181184.[Crossref]
    [Google Scholar]
  7. Schmunis GA, 1999. Iniciativa del Cono Sur. Proceedings of the II International Workshop on Population Genetics and Control of Triatominae, Tegucigalpa, Honduras, pp. 2631.
    [Google Scholar]
  8. Moncayo A, 2003. Chagas disease: current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries. Mem Inst Oswaldo Cruz 98: 577591.[Crossref]
    [Google Scholar]
  9. Morel CM, Lazdins J, 2003. Focus: Chagas disease. Nature Reviews Microbiology 1: 1415.[Crossref]
    [Google Scholar]
  10. Trischmann TM, Bloom BR, 1982. Genetics of murine resistance to Trypanosoma cruzi. Infect Immun 35: 546551.
    [Google Scholar]
  11. Silva JS, Vespa GNR, Cardillo F, Cardoso MAG, Martins GA, Rodrigues V, 1993. O papel de citocinas no determinismo de resistência ou susceptibilidade à infecção pelo Trypanosoma cruzi. Rev Soc Bras Med Trop 26 (Suppl 2): 1718.
    [Google Scholar]
  12. Reed SG, Brownell CE, Russo DM, Silva JS, Grabstein KH, Morrissey PJ, 1994. IL-10 mediates susceptibility to Trypanosoma cruzi infection. Journal of Immunology 153: 31353140.
    [Google Scholar]
  13. Chandrasekar B, Melby PC, Troyer DA, Freeman GL, 1996. Induction of proinflammatory cytokyne expression in experimental acute chagasic cardiomyopathy. Biochem Biophys Res Commun 223: 365371.[Crossref]
    [Google Scholar]
  14. Andrade ALS, Zicker F, Silva IG, Souza JMP, Martelli CMT, 1995. Risk factors for Trypanosoma cruzi infection among children in central Brazil: a case-control study in vector control settings. Am J Trop Med Hyg 52: 183187.
    [Google Scholar]
  15. Williams-Blangero S, Vandeberg JL, Blangero J, Teixeira ARL, 1997. Genetic epidemiology of seropositivity for Trypanosoma cruzi infection in rural Goiás, Brazil. Am J Trop Med Hyg 57: 538543.
    [Google Scholar]
  16. Bahia-Oliveira LMG, Gomes JAS, Rocha MOC, Moreira MCV, Lemos EM, Luz ZMP, Pereira MES, Coffman RL, Dias JCP, Cançado JR, Gazzinelli G, Côrrea-Oliveira R, 1998. IFN-γ in human Chagas’ disease: protection or pathology? Braz J Med Biol Res 31: 127131.[Crossref]
    [Google Scholar]
  17. Corrêa-Oliveira R, Gomes JAS, Lemos EM, Cardoso GM, Reis DD, Adad S, Crema E, Martins-Filho AO, Costa MOR, Gazzinelli G, Bahia-Oliveira LMG, 1999. The role of immune response on the development of severe clinical forms of human Chagas disease. Mem Inst Oswaldo Cruz 94 (Suppl 1): 253255.[Crossref]
    [Google Scholar]
  18. Vinhaes MC, Dias JCP, 2000. Doença de Chagas no Brasil. Cad Saude Publica 16 (Suppl 2): 712.[Crossref]
    [Google Scholar]
  19. Villela MM, Souza JMB, Melo VP, Dias JCP, 2009. Avaliação do Programa de Controle da Doença de Chagas em relação à presença de Panstrongylus megistus na região centro-oeste do Estado de Minas Gerais, Brasil. Cad Saude Publica 25: 907917.[Crossref]
    [Google Scholar]
  20. Anonymous, 1985. Validade do conceito de forma indeterminada de doença de Chagas. Rev Soc Bras Med Trop 18: 46.[Crossref]
    [Google Scholar]
  21. Prata A, 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1: 92100.[Crossref]
    [Google Scholar]
  22. Rezende JM, Lauar KM, Oliveira AR, 1960. Aspectos clínicos e radiológicos da aperistalse do esôfago. Revista Brasileira de Gastroenterologia 12: 247262.
    [Google Scholar]
  23. Rezende JM, Moreira H, 1976. Megacolo chagásico. Porto JAF, ed. Clínica das Doenças Intestinais. Rio de Janeiro: Atheneu, 451474.
    [Google Scholar]
  24. Bonney GE, 1984. On the statistical determination of major gene mechanisms in continuous human traits. Am J Med Genet 18: 731749.[Crossref]
    [Google Scholar]
  25. Moncayo A, Yanine MIO, 2006. An update on Chagas disease (human American trypanosomiasis). Ann Trop Med Parasitol 100: 115.[Crossref]
    [Google Scholar]
  26. Pereira JB, Coura JR, 1986. Morbidade da doença de Chagas. Estudo seccional em uma área endêmica, Virgem da Lapa, Minas Gerais. Rev Soc Bras Med Trop 19: 139148.[Crossref]
    [Google Scholar]
  27. Chapadeiro E, Lopes ER, Mesquita PM, Pereira FEL, 1964. Incidência de “megas” associados à cardiopatia chagásica. Rev Inst Med Trop Sao Paulo 6: 287291.
    [Google Scholar]
  28. Coura JR, Abreu LL, Dubois LEG, Lima FC, Arruda Júnior E, Willcox HPF, Anunziato N, Petana W, 1984. Morbidade da doença de Chagas. II—Estudo seccionais em quatro áreas de campo no Brasil. Mem Inst Oswaldo Cruz 79: 101124.[Crossref]
    [Google Scholar]
  29. Maguire JH, Hoff R, Sherlock I, Guimarães AC, Sleigh AC, Ramos NB, Mott KE, Weller TH, 1987. Cardiac morbidity and mortality due to Chagas’ disease: prospective electrocardiographic study of a Brazilian community. Circulation 75: 11401145.[Crossref]
    [Google Scholar]
  30. Laranja FS, Dias E, Duarte E, Pellegrino J, 1951. Observações clínicas e epidemiológicas sobre a moléstia de Chagas no oeste de Minas Gerais. Hospital Med 40: 945988.
    [Google Scholar]
  31. Dias E, Laranja FS, Nóbrega G, 1945. Doença de Chagas. Mem Inst Oswaldo Cruz 42: 495582.
    [Google Scholar]
  32. Lucena DT, Costa EG, Cordeiro E, 1963. Alterações eletrocardiográficas na doença de Chagas, no nordeste do Brasil. Revista Brasileira de Malariologia e Doenças Tropicais 15: 369390.
    [Google Scholar]
  33. Baruffa G, Aquino Neto JO, Alcântara Filho A, Bettini VN, Bertinetti ES, 1972. Dados preliminares de inquérito sorológico e eletrocardiográfico para doença de Chagas em populações rurais não selecionadas da zona sul do Rio Grande do Sul. Rev Soc Bras Med Trop 6: 362363.
    [Google Scholar]
  34. Macêdo V, Prata A, Silva GR, Castilho E, 1982. Prevalência de alterações eletrocardiográficas em chagásicos. (Informações preliminares sobre o inquérito eletrocardiográfico nacional). Arq Bras Cardiol 34: 261264.
    [Google Scholar]
  35. Castro C, Macêdo V, Rezende JM, Prata A, 1994. Estudo radiológico longitudinal do esôfago, em área endêmica de doença de Chagas, em um período de 13 anos. Rev Soc Bras Med Trop 27: 227233.[Crossref]
    [Google Scholar]
  36. Pereira JB, Cunha RV, Willcox HPF, Coura JR, 1990. Evolução da cardiopatia chagásica crônica humana no sertão do estado da Paraíba, Brasil, no período de 4,5 anos. Rev Soc Bras Med Trop 23: 141147.[Crossref]
    [Google Scholar]
  37. Correia D, Junqueira LF, Molina RJ, Prata A, 2007. Cardiac autonomic modulation evaluated by heart interval variability is unaltered but subtly widespread in the indeterminate Chagas’ disease. Pacing Clin Electrophysiol 30: 772780.[Crossref]
    [Google Scholar]
  38. Resende LAPR, Molina RJ, Ferreira BDC, Carneiro AC, Ferreira LAA, Silva VJD, Prata A, Correia D, 2007. Cardiac autonomic function in chagasic elderly patients in an endemic área: a time and frequency domain analysis approach. Auton Neurosci 131: 94101.[Crossref]
    [Google Scholar]
  39. Pereira JB, Willcox HPF, Coura JR, 1992. Evolução da cardiopatia chagásica crônica. I—Influência da parasitemia. Rev Soc Bras Med Trop 25: 101108.[Crossref]
    [Google Scholar]
  40. Souza W, 2000. O parasita e sua interação com os hospedeiros. Brenner Z, Andrade ZA, Barral-Neto M, eds. Trypanosoma cruzi e doença de Chagas. Rio de Janeiro: Guanabara Koogan, 88126.
    [Google Scholar]
  41. Abel L, Dessein AJ, 1997. The impact of host genetics on susceptibility to human infectious diseases. Curr Opin Immunol 9: 509516.[Crossref]
    [Google Scholar]
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  • Received : 02 Dec 2009
  • Accepted : 28 Sep 2009
  • Published online : 05 Jan 2010
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