1921
Volume 82, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

A prospective cohort design was used to measure the association between daily cotrimoxazole-prophylaxis and infection with containing mutations associated with antifolate resistance among persons infected with human immunodeficiency virus (HIV) in Tororo and Busia District, in eastern Uganda. Of 149 cases of parasitemia diagnosed, 147 (99%) (smears from participants taking prophylaxis = 91 and smears from those not taking cotrimoxazole prophylaxis = 56) were successfully assessed for mutations in the dihydrofolate reductase () and dihydropteroate synthase () mutations associated with antifolate resistance. Prevalences of the pure triple mutant (74% and 70%; = 0.71), the pure double mutant (95% and 88%; = 0.21), and the pure quintuple mutant (73% and 64%; = 0.36), were not significantly different between those taking and those not taking cotrimoxazole-prophylaxis, respectively. The overall prevalence of the pure quintuple mutant in this study was 69%, which is among the highest in Africa. Although resistance rates of to antifolate drugs are high, cotrimoxazole-prophylaxis in HIV-infected persons was not associated with a higher prevalence of mutations associated with antifolate resistance.

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2017-11-17
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  • Received : 14 Aug 2008
  • Accepted : 02 Jan 2010

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