1921
Volume 82, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Abstract.

Nucleotide sequence analysis of the PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006–2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2010.08-0332
2010-04-01
2017-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/82/4/522.html?itemId=/content/journals/10.4269/ajtmh.2010.08-0332&mimeType=html&fmt=ahah

References

  1. Arevalo-Herrera M, Herrera S, , 2001. Plasmodium vivax malaria vaccine development. Mol Immunol 38: 443455.[Crossref]
  2. Bruce MC, Galinski MR, Barnwell JW, Snounou G, Day KP, , 1999. Polymorphism at the merozoite surface protein-3α locus of Plasmodium vivax: global and local diversity. Am J Trop Med Hyg 61: 518525.
  3. Rayner JC, Corredor V, Feldman D, Ingravallo P, Iderabdullah F, Galinski MR, Barnwell JW, , 2002. Extensive polymorphism in the Plasmodium vivax merozoite surface coat protein MSP-3α is limited to specific domains. Parasitology 125: 393405.[Crossref]
  4. Galinski MR, Corredor-Medina CC, Povoa M, Crosby J, Ingravallo P, Barnwell JW, , 1999. Plasmodium vivax merozoite surface protein-3 contains coiled-coil motifs in an alanine-rich central domain. Mol Biochem Parasitol 101: 131147.[Crossref]
  5. Galinski MR, Ingravallo P, Corredor-Medina C, Al-Khedery B, Povoa M, Barnwell JW, , 2001. Plasmodium vivax merozoite surface proteins-3beta and-3gamma share structural similarities with P. vivax merozoite surface protein-3alpha and define a new gene family. Mol Biochem Parasitol 115: 4153.[Crossref]
  6. Bruce MC, Galinski MR, Barnwell JW, Donnelly CA, Walmsley M, Alpers MP, Walliker D, Day KP, , 2000. Genetic diversity and dynamics of Plasmodium falciparum and P. vivax populations in multiply infected children with asymptomatic malaria infections in Papua New Guinea. Parasitology 121: 257272.[Crossref]
  7. Cui L, Mascorro CN, Fan Q, Rzomp KA, Khuntirat B, Zhou G, Chen H, Yan G, Sattabongkot J, , 2003. Genetic diversity and multiple infections of Plasmodium vivax malaria in western Thailand. Am J Trop Med Hyg 68: 613619.
  8. Korea Center for Disease Control and Prevention, 2008. 2008 Guidelines for Malaria Control. Seoul: Korea Center for Disease Control and Prevention, 52.
  9. Han ET, Song TE, Park JH, Shin EH, Guk SM, Kim TY, Chai JY, , 2004. Allelic dimorphism in the merozoite surface protein-3α in Korean isolates of Plasmodium vivax . Am J Trop Med Hyg 71: 745749.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2010.08-0332
Loading
/content/journals/10.4269/ajtmh.2010.08-0332
Loading

Data & Media loading...

  • Received : 07 Jul 2008
  • Accepted : 18 Jan 2010

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error