1921
Volume 81, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Corticosteroid and the combination of corticosteroid and antihelminthic drug are safe and beneficial in relieving headaches in patients with eosinophilic meningitis. However, clinical trials comparing the efficacies of these regimens have never been reported. We conducted a prospective, open, randomized, controlled study to compare the efficacy of the combination of prednisolone plus albendazole and prednisolone alone for the treatment of eosinophilic meningitis. Our study had 53 patients in the combined treatment group and 51 patients in the prednisolone alone group. There were no significant differences between the two groups with regard to the number of patients who still had headaches after 14 days (0 versus 1, respectively; = 0.49) and the median length of time until complete disappearance of headache (3 versus 3 days, respectively; = 0.32. Prednisolone plus albendazole is no better than prednisolone alone for treatment of patients with eosinophilic meningitis.

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2009-09-01
2017-09-25
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References

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  7. Koo J, Pien F, Kliks MM, 1988. Angiostrongylus (Parastrongylus) eosinophilic meningitis. Rev Infect Dis 10 : 1155–1162.
  8. Kliks MM, Kroenke K, Hardman JM, 1982. Eosinophilic radiculo-myeloencephalitis: an angiostrongylus outbreak in American Samoa related to ingestion of Achatina fulica snails. Am J Trop Med Hyg 31 : 1114–1122.
  9. Jitpimolmard S, Sawnayawisuth K, Morakote N, Vejjajiva A, Puntumetakul M, Sanchaisuriya K, Tassaneeyakul W, Tassaneeyakul W, Korwanich N, 2007. Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis. Parasitol Res 100 : 1293–1296.
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  • Received : 20 Mar 2009
  • Accepted : 13 May 2009

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