Volume 81, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Here we describe clinical and pathologic evidence of Chagas disease caused in dogs by circulating from a newly recognized endemic area in Mexico. We show that the isolate, although less virulent than the reference strain that caused acute myocarditis and death, was pathogenic in dogs. Dogs infected with the isolate exhibited electrocardiographic alterations, left- and right-ventricle dilation, and hydropericardium. Histologically, diffused perimysial and endomysial lymphoplasmacytic cell infiltration, cardiomyocyte necrosis, and amastigote nests were noted in -infected dogs. These findings suggest that the risk of infection and Chagas disease is present in the State of Mexico, and further research is needed to identify the bio-types circulating in southern State of Mexico.


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  • Received : 04 Mar 2008
  • Accepted : 18 Apr 2009

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