1921
Volume 81, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We report the first case of granulomatous amebic encephalitis caused by in a previously healthy farmer in Taiwan who fell into a ditch. The DNA amplicons of amebas identified by polymerase chain reaction in the cerebrospinal fluid specimen and the ditch water specimens were identical and shared strong homology with . He survived after treatment with amphotericin B, rifampin, and corticosteroids.

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References

  1. Ma P, Visvesvara GS, Martinez AJ, Theodore FH, Dagget PM, Sawyer TK, 1990. Naeglaria and Acanthamoeba infections. Rev Infect Dis 12 : 490–513. [Google Scholar]
  2. Marciano-Cabral F, 2003. Acanthamoeba spp. as agents of disease in humans. Clin Microbiol Rev 16 : 273–307. [Google Scholar]
  3. Schuster FL, 2004. Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals. Int J Parasitol 34 : 1001–1027. [Google Scholar]
  4. Qvarnstrom Y, Visvesvara GS, Sriram R, da Silva AJ, 2006. Multiplex real-time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. J Clin Microbiol 44 : 3589–3595. [Google Scholar]
  5. Schild M, Gianinazzi C, Gottstein B, Muller N, 2007. PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffin-embedded brain sections. J Clin Microbiol 45 : 564–567. [Google Scholar]
  6. Schroeder JM, Booton GC, Hay J, Niszl IA, Seal DV, Markus MB, Fuerst PA, Byers TJ, 2001. Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge. J Clin Microbiol 39 : 1903–1911. [Google Scholar]
  7. Higgins DG, Sharp PM, 1988. CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. Gene 73 : 237–244. [Google Scholar]
  8. Tamura K, Dudley J, Nei M, Kumar S, 2007. MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0. Mol Biol Evol 24 : 1596–1599. [Google Scholar]
  9. Sison JP, Kemper CA, Loveless M, McShane D, Visvesvara GS, Deresinski SC, 1995. Disseminated Acanthamoeba infection in patients with AIDS: case reports and review. Clin Infect Dis 20 : 1207–1216. [Google Scholar]
  10. Martinez AJ, Visvesvara GS, 1997. Free-living, amphizoic and opportunistic amebas. Brain Pathol 7 : 583–598. [Google Scholar]
  11. Kidney DD, Kim SH, 1998. CNS infections with free living amebas: neuroimaging findings. AJR Am J Roentgenol 171 : 809–812. [Google Scholar]
  12. Lalitha MK, Anandi V, Srivastava A, Thomas K, Cherian AM, Chandi SM, 1985. Isolation of Acanthamoeba culbertsoni from a patient with meningitis. J Clin Microbiol 21 : 666–667. [Google Scholar]
  13. Carter RF, Cullity GJ, Ojeda VJ, Silberstein P, Willaert E, 1981. A fatal case of meningocephalitis due to a free-living ameba of uncertain identity: probably Acanthamoeba sp. Pathology 13 : 51–68. [Google Scholar]
  14. Walochnik J, Aichelburg A, Assadian O, Steuer A, Visvesvara G, Vetter N, Aspock H, 2008. Granulomatous amoebic encephalitis caused by Acanthamoeba amoebae of genotype T2 in a human immunodeficiency-virus negative patient. J Clin Microbiol 46 : 338–340. [Google Scholar]
  15. Bloch KC, Schuster FL, 2005. Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous amebic encephalitis. J Clin Microbiol 43 : 3003–3006. [Google Scholar]
  16. Ferante A, Rowen Kelly B, Thong YH, 1984. In vitro sensitivity of virulent Acanthamoeba culbertsoni to a variety of drugs and antibiotics. Int J Parasitol 14 : 53–56. [Google Scholar]
  17. Stevens AR, Willaert E, 1980. Drug sensitivity and resistance of four Acanthamoeba species. Trans R Soc Trop Med Hyg 74 : 806–808. [Google Scholar]
  18. Das SR, Asiri S, el Soofi A, Baer HP, 1991. Protective and curative effects of rifampicin in Acanthamoeba meningitis of the mouse. J Infect Dis 163 : 916–917. [Google Scholar]
  19. Rowen Kelly B, Ferante A, Thong YH, 1982. The chemotherapeutic value of sulphadiazine in treatment of Acanthamoeba meningoencephalitis in mice. Trans R Soc Trop Med Hyg 76 : 636–638. [Google Scholar]
  20. Slater CA, Sickel JZ, Visvesvara GS, Pabico RC, Gaspari AA, 1994. Successful treatment of disseminated Acanthamoeba infection in an immunocompromised patient. N Engl J Med 331 : 85–87. [Google Scholar]
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  • Received : 13 May 2009
  • Accepted : 23 May 2009

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