1921
Volume 81, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two genes. Lao blood donors and patients with fever, hepatitis, or jaundice ( = 1,132) had a high prevalence (17%) of immunofluorescence assay IgG anti- antibodies compared with 4% and 0% from febrile patients ( = 848) in Thailand and Malaysia, respectively. We found DNA by PCR, for the first time, in a fish (). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish.

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References

  1. Misao T, Kobayashi Y, 1954. Studies on mononucleosis. 1 report. Isolation of the infectious agent [in Japanese]. Fukuoka Med J 45 : 519.
  2. Fukuda T, Kitao T, Keida Y, 1954. Studies on the causative agent of “Hyuganetsu” disease. 1. Isolation of the agent and its inoculation trial in human beings [in Japanese]. Med Biol 32 : 200–209.
  3. Misao TY, Kobayashi Y, Shirakawa M, 1978. La mononucleose infecteuse (fibvre ganglionaire) [in French]. Sang 28 : 785–805.
  4. Tachibana N, 1986. Sennetsu fever: the disease, diagnosis, and treatment. Leive L, editor. Microbiology. Washington, DC: American Society for Microbiology, 205–208.
  5. Rikihisa Y, 1991. The tribe Ehrlichieae and ehrlichial diseases. Clin Microbiol Rev 4 : 286–308.
  6. Hirai K, 1966. Study of infectious mononucleosis in Kumamoto Prefecture. 1. Isolation of a Rickettsia sennetsu-like organism from patients with epidemic glandular fever [in Japanese]. Kumamoto Igakkai Zasshi 40 : 1159–1173.
  7. Dumler JS, Barbet AF, Bekker CP, Dasch GA, Palmer GH, Ray SC, Rikihisa Y, Rurangirwa FR, 2001. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and ‘HGE agent’ as subjective synonyms of Ehrlichia phagocytophila. Int J Syst Evol Microbiol 51 : 2145–2165.
  8. Rikihisa Y, Zhang C, Kanter M, Cheng Z, Ohashi N, Fukuda T, 2004. Analysis of p51, groESL, and the major antigen P51 in various species of Neorickettsia, an obligatory intracellular bacterium that infects trematodes and mammals. J Clin Microbiol 42 : 3823–3826.
  9. Hotopp JC, Lin M, Madupu R, Crabtree J, Angiuoli SV, Eisen JA, Seshadri R, Ren Q, Wu M, Utterback TR, Smith S, Lewis M, Khouri H, Zhang C, Niu H, Lin Q, Ohashi N, Zhi N, Nelson W, Brinkac LM, Dodson RJ, Rosovitz MJ, Sundaram J, Daugherty SC, Davidsen T, Durkin AS, Gwinn M, Haft DH, Selengut JD, Sullivan SA, Zafar N, Zhou L, Benahmed F, Forberger H, Halpin R, Mulligan S, Robinson J, White O, Rikihisa Y, Tettelin H, 2006. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2 : e21.
  10. Wen B, Rikihisa Y, Yamamoto S, Kawabata N, Fuerst PA, 1996. Characterization of the SF agent, an Ehrlichia sp. isolated from the fluke Stellantchasmus falcatus, by 16S rRNA base sequence, serological, and morphological analyses. Int J Syst Bacteriol 46 : 149–154.
  11. Shishido A, Honjo S, Suganuma M, Ohtaki S, Hikita M, Fujiwara T, Takasaka M, 1965. Studies on infectious mononucleosis induced in the monkey by experimental infection with Rickettsia sennetsu. Jpn J Med Sci Biol 18 : 73–83.
  12. Holland CJ, Ristic M, Huxsoll DL, Cole AI, Rapmund G, 1985. Adaptation of Ehrlichia sennetsu to canine blood monocytes: preliminary structural and serological studies with cell culture-derived Ehrlichia sennetsu. Infect Immun 48 : 366–371.
  13. Ristic M, 1990. Current strategies in research on ehrlichioisis. Williams JC, Kakoma I, eds. Ehrlichiosis: A Vector Borne Disease of Animals and Humans. Dordecht: Kluwer Academic Publishers, 136–153.
  14. Phongmany S, Rolain JM, Phetsouvanh R, Blacksell SD, Soukkhaseum V, Rasachack B, Phiasakha K, Soukkhaseum S, Frichithavong K, Chu V, Keolouangkhot V, Martinez-Aussel B, Chang K, Darasavath C, Rattanavong O, Sisouphone S, Mayxay M, Vidamaly S, Parola P, Thammavong C, Heuangvongsy M, Syhavong B, Raoult D, White NJ, Newton PN, 2006. Rickettsial infections and fever, Vientiane, Laos. Emerg Infect Dis 12 : 256–262.
  15. Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, Suwancharoen D, Panlar P, Saisongkorh W, Rolain JM, Raoult D, Suputtamongkol Y, 2006. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 100 : 363–370.
  16. Kottelat M, 2001. Fishes of Laos. Colombo, Sri Lanka: WHT Publications.
  17. Parola P, Roux V, Camicas JL, Baradji I, Brouqui P, Raoult D, 2000. Detection of ehrlichiae in African ticks by polymerase chain reaction. Trans R Soc Trop Med Hyg 94 : 707–708.
  18. Inokuma H, Brouqui P, Drancourt M, Raoult D, 2001. Citrate synthase gene sequence: a new tool for phylogenetic analysis and identification of Ehrlichia. J Clin Microbiol 39 : 3031–3039.
  19. Rolain JM, Gouriet F, Brouqui P, Larrey D, Janbon F, Vene S, Jarnestrom V, Raoult D, 2005. Concomitant or consecutive infection with Coxiella burnetii and tickborne diseases. Clin Infect Dis 40 : 82–88.
  20. Mekong River Commission, 2003. The MRC Mekong Fish Database CD. Vientiane, Lao PDR: Mekong River Commission.
  21. Brouqui P, Raoult D, 1990. In vitro susceptibility of Ehrlichia sennetsu to antibiotics. Antimicrob Agents Chemother 34 : 1593–1596.
  22. Fukuda T, Sasahara T, Kitao T, 1962. Studies on the causative agent of Hyuga fever. 10. The vector. Jpn J Infect Dis 36 : 235–241.
  23. Sripa B, 2008. Concerted action is needed to tackle liver fluke infections in Asia. PLoS Negl Trop Dis 2 : e232.
  24. Sayasone S, Odermatt P, Phoumindr N, Vongsaravane X, Sensombath V, Phetsouvanh R, Choulamany X, Strobel M, 2007. Epidemiology of Opisthorchis viverrini in a rural district of southern Lao PDR. Trans R Soc Trop Med Hyg 101 : 40–47.
  25. Sithithaworn P, Sukavat K, Vannachone B, Sophonphong K, Ben-Embarek P, 2006. Epidemiology of food-borne trematodes and other parasite infections in a fishing community on the Nam Ngum reservoir, Lao PDR. SE Asian J Trop Med Publ Hlth 37 : 1083–1090.
  26. Unnevehr L, Roberts T, 2002. Food safety incentives in a changing world food system. Food Contr 13 : 73–76.
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Supplementary Data

Supplementary material

  • Received : 31 Jan 2009
  • Accepted : 07 May 2009

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