Volume 81, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two genes. Lao blood donors and patients with fever, hepatitis, or jaundice ( = 1,132) had a high prevalence (17%) of immunofluorescence assay IgG anti- antibodies compared with 4% and 0% from febrile patients ( = 848) in Thailand and Malaysia, respectively. We found DNA by PCR, for the first time, in a fish (). These data suggest that sennetsu may be an under-recognized cause of fever and are consistent with the hypothesis that it may be contracted from eating raw fish.


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Supplementary material

  • Received : 31 Jan 2009
  • Accepted : 07 May 2009

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