1921
Volume 81, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Hepatitis C virus (HCV) infection occurs among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM) because of shared routes of transmission. To assess the association between HCV and HIV infection among MSM in Peru, we conducted a matched case-control study (162 HIV-positive cases and 324 HIV-negative controls) among participants of an HIV sentinel surveillance survey in six urban cities. The HCV infection was initially screened using anti-HCV ELISA and immunoblot assay, and thereafter confirmed by the HCV RNA qualitative assay. Among cases, no confirmed HCV infection was found while among controls, only two confirmed HCV infections were reported (0.62%). This matched case-control reports a very low probability of association between HCV and HIV co-infection and suggests a very low prevalence of HCV infection among MSM in Peru.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2009.81.184
2009-07-01
2017-11-18
Loading full text...

Full text loading...

/deliver/fulltext/14761645/81/1/0810184.html?itemId=/content/journals/10.4269/ajtmh.2009.81.184&mimeType=html&fmt=ahah

References

  1. Macdonald N, Dougan S, McGarrigle CA, Baster K, Rice BD, Evans BG, Fenton KA, 2004. Recent trends in diagnoses of HIV and other sexually transmitted infections in England and Wales among men who have sex with men. Sex Transm Infect 80 : 492–497.
  2. Alter MJ, 2002. Prevention of spread of hepatitis C. Hepatology 36 : S93–S98.
  3. Bautista CT, Sanchez JL, Montano SM, Laguna-Torres VA, Lama JR, Kusunoki L, Manrique H, Acosta J, Montoya O, Tambare AM, Avila MM, Vinoles J, Aguayo N, Olson JG, Carr JK, 2004. Seroprevalence of and risk factors for HIV-1 infection among South American men who have sex with men. Sex Transm Infect 80 : 498–504.
  4. Lama JR, Lucchetti A, Suarez L, Laguna-Torres VA, Guanira JV, Pun M, Montano SM, Celum CL, Carr JK, Sanchez J, Bautista CT, Sanchez JL, 2006. Association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in Peru. J Infect Dis 194 : 1459–1466.
  5. Alary M, Joly JR, Vincelette J, Lavoie R, Turmel B, Remis RS, 2005. Lack of evidence of sexual transmission of hepatitis C virus in a prospective cohort study of men who have sex with men. Am J Public Health 95 : 502–505.
  6. Rauch A, Rickenbach M, Weber R, Hirschel B, Tarr PE, Bucher HC, Vernazza P, Bernasconi E, Zinkernagel AS, Evison J, Furrer H, 2005. Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. Clin Infect Dis 41 : 395–402.
  7. Eyster ME, Alter HJ, Aledort LM, Quan S, Hatzakis A, Goedert JJ, 1991. Heterosexual co-transmission of hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Ann Intern Med 115 : 764–768.
  8. Sanchez JL, Sjogren MH, Callahan JD, Watts DM, Lucas C, Abdel-Hamid M, Constantine NT, Hyams KC, Hinostroza S, Figueroa-Barrios R, Cuthie JC, 2000. Hepatitis C in Peru: risk factors for infection, potential iatrogenic transmission, and genotype distribution. Am J Trop Med Hyg 63 : 242–248.
  9. Pawlotsky JM, 2002. Use and interpretation of virological tests for hepatitis C. Hepatology 36 : S65–S73.
  10. Alter MJ, Kuhnert WL, Finelli L, 2003. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 52 : 1–13, 15 quiz CE1–4.
  11. Sayan M, Meric M, Mutlu B, Celebi S, Willke A, 2006. Low positive anti-HCV microparticle enzyme immunoassay results: do they predict hepatitis C virus infection? Mikrobiyol Bul 40 : 81–84.
  12. Buffington J, Murray PJ, Schlanger K, Shih L, Badsgard T, Hennessy RR, Wood R, Weisfuse IB, Gunn RA, 2007. Low prevalence of hepatitis C virus antibody in men who have sex with men who do not inject drugs. Public Health Rep 122 (Suppl 2) : 63–67.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2009.81.184
Loading
/content/journals/10.4269/ajtmh.2009.81.184
Loading

Data & Media loading...

  • Received : 22 Dec 2008
  • Accepted : 11 Feb 2009

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error