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Volume 81, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

With the implementation of mass drug administration programs for the control of human hookworms, there is a need to monitor for the emergence of drug resistance. We have therefore examined assays for monitoring sensitivity to benzimidazoles (egg hatch assay) and nicotinic acetylcholine receptor agonist drugs (motility and morphology assays), with a view to developing tools for monitoring drug sensitivity in the field. We have performed assays with and , and combined this with published data on and , to indicate the breadth of the responses of various hookworm species and isolates in these assays. This has allowed us to generate assay templates covering the known range of responses, with scope to cover any shift in response that may be indicative of resistance. These assays will have immediate applicability in monitoring for the emergence of drug resistance in human hookworm populations.

Copyright 2009 The American Society of Tropical Medicine
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Dose-Response Assay Templates for In vitro Assessment of Resistance to Benzimidazole and Nicotinic Acetylcholine Receptor Agonist Drugs in Human Hookworms
The American Journal of Tropical Medicine and Hygiene 81, 163 (2009); https://doi.org/10.4269/ajtmh.2009.81.163
/content/journals/10.4269/ajtmh.2009.81.163
/content/journals/10.4269/ajtmh.2009.81.163
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  • Received : 30 Jan 2009
  • Accepted : 24 Mar 2009

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