Volume 80, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The aim was to evaluate the efficacy of (Sb) in addition to metronidazole in amebiasis. A prospective, randomized, open clinical trial was performed in 50 children presenting with acute bloody diarrhea caused by . Group A and B (each = 25) was treated with metronidazole, but Sb (250 mg, twice daily) during the 7 days was added to Group B patients who were re-evaluated 2, 3, 5, 10, and 30 days after diagnosis. Duration of bloody diarrhea was significantly longer in Group A (72.0 ± 28.5 versus 42.2 ± 17.4 hours, < 0.001). On day 5, amebic cysts had disappeared in all children in Group B, whereas in Group A, amebic cysts were still present in 6 children ( < 0.05). On day 10, all children were cured and cysts had disappeared in all. The addition of Sb to metronidazole in amebiasis significantly decreases duration of (bloody) diarrhea and enhances clearance of cysts.


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  • Received : 16 Dec 2008
  • Accepted : 07 Mar 2009

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