1921
Volume 80, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The antimalarial susceptibility of ring stage (> 80%) from the Republic of Korea, where long incubation–period strains are prevalent, was evaluated using the schizont maturation inhibition technique. During 2005–2007, susceptibility to seven antimalarial drugs was evaluated with 24 fresh isolates. The geometric mean (95% confidence interval) 50% inhibition concentration (IC) were quinine 60 (54–75) ng/mL, chloroquine 39 (22–282) ng/mL, piperaquine 27 (17–58) ng/mL, mefloquine 39 (35–67) ng/mL, pyrimethamine 138 (89–280) ng/mL, artesunate 0.6 (0.5–0.8) ng/mL, and primaquine 122 (98–232) ng/mL. Positive correlations were found between quinine and mefloquine (r = 0.6, = 0.004), piperaquine and chloroquine (r = 0.6, = 0.008), and piperaquine and primaquine IC values (r = 0.5, = 0.01). Compared with in Thailand, in the Republic of Korea was more sensitive to quinine and mefloquine, but equally sensitive to chloroquine and artesunate.

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  • Received : 04 Sep 2008
  • Accepted : 11 Feb 2009

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