Volume 80, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


monkeys infected with the Hackeri strain of had maximum parasite counts ranging from 1,300 to 301,320/μL. In 43 intact animals infected with the ABI strain, the maximum parasite counts ranged from 672 to 57,189/μL (median = 15,100/μL); in 46 splenectomized monkeys, the maximum parasite count ranged from 660 to 350,000/μL (median = 52,245/μL). Transmission through mosquitoes was obtained on 11 occasions with pre-patent periods of 9–14 days. Relapses occurred between two and eight times during a 1-year period. has potential for testing prophylactic and radical curative drugs.


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  1. Schmidt L, 1973. Infections with Plasmodium falciparum and Plasmodium vivax infections in the owl monkey—model systems for basic biological and chemotherapeutic studies. Trans R Soc Trop Med Hyg 67 : 446–474. [Google Scholar]
  2. Collins WE, Anders RF, Ruebush TK II, Kemp DJ, Woodrow GC, Campbell GH, Brown GV, Irving DO, Gross N, Filipski VK, Coppel RL, Broderson JR, Thomas LM, Pye D, Skinner JC, Wilson C, Stanfill PS, Procell PM, 1991. Immunization of owl monkeys with ring-infected erythrocyte surface antigen of Plasmodium falciparum. Am J Trop Med Hyg 44 : 34–41. [Google Scholar]
  3. Collins WE, Skinner JC, Millet P, Filipski VK, Morris CL, Wilkins PM, Campbell GH, Stanfill PS, Richardson BB, Sullivan J, 1992. Reinforcement of immunity in Saimiri monkeys following immunization with irradiated sporozoites of Plasmodium vivax. Am J Trop Med Hyg 46 : 327–334. [Google Scholar]
  4. Coatney GR, Collins WE, Warren McW, Contacos PG, 1971. The Primate Malarias. Washington, DC: US Government Printing Office.
  5. Coatney GR, 1971. The simian malarias: zoonoses, anthroponoses, or both? Am J Trop Med Hyg 20 : 795–803. [Google Scholar]
  6. Collins WE, Warren McW, Sullivan JS, Galland GG, 2001. Plasmodium coatneyi: Observations on periodicity, mosquito infection, and transmission to Macaca mulatta monkeys. Am J Trop Med Hyg 64 : 101–110. [Google Scholar]
  7. Eyles DE, Laing ABG, Fong YL, 1962. Plasmodium fieldi sp. nov., a new species of malaria parasite from the pig-tailed macaque in Malaya. Ann Trop Med Parasitol 56 : 225–227. [Google Scholar]
  8. Warren Mc W, Wharton RH, 1963. The vectors of simian malaria: identity, biology, and geographical distribution. J Parasitol 49 : 892–904. [Google Scholar]
  9. Warren M, Ali K, Bennett GF, Sandosham AA, 1964. Morphology of Plasmodium fieldi in different species of the genus Macaca. Med J Malaysia 19 : 31. [Google Scholar]
  10. Held JR, Contacos PG, Coatney GR, 1967. Studies on the exoerythrocytic stages of simian malaria. I. Plasmodium fieldi. J Parasitol 53 : 225–232. [Google Scholar]
  11. Coombs GL, Fredericks HJ, Cheong WH, Sandosham AA, Sta Maria FL, 1968. The exoerythrocytic schizonts of Plasmodium fieldi. Med J Malaysia 22 : 225–227. [Google Scholar]
  12. Collins WE, Guinn EG, Held JR, 1968. Transmission of Plasmodium fieldi by Anopheles maculatus, A. stephensi, and A. balabacensis balabacensis. J Parasitol 54 : 376. [Google Scholar]
  13. Collins WE, Contacos PG, 1971. Observations on the relapse activity of Plasmodium fieldi in the rhesus monkey. J Parasitol 57 : 29–32. [Google Scholar]
  14. Collins WE, Skinner JC, Contacos PG, Guinn EG, Richardson BB, 1973. The influence of splenectomy on infections with Plasmodium fieldi in Macaca mulatta monkeys. J Parasitol 59 : 41–48. [Google Scholar]
  15. Millet P, Anderson P, Collins WE, 1994. In vitro cultivation of exoerythrocytic stages of the simian malaria parasites Plasmodium fieldi and P. simiovale in rhesus monkey hepatocytes. J Parasitol 80 : 384–388. [Google Scholar]
  16. Sullivan JS, Morris CL, Richardson BB, Galland GG, Collins WE, 1998. Attempts to transmit the N-3 strain of Plasmodium fieldi to Aotus monkeys. J Parasitol 84 : 195–197. [Google Scholar]
  17. Collins WE, Skinner JC, Broderson JR, Filipski VK, Morris CM, Stanfill PS, Warren M, 1992. Susceptibility of Macaca fascicularis monkeys from Mauritius to different species of Plasmodium. J Parasitol 78 : 505–511. [Google Scholar]
  18. Collins WE, Jeffery GM, Guinn E, Skinner JC, 1966. Fluorescent antibody studies in human malaria. IV. Cross-reactions between human and simian malaria. Am J Trop Med Hyg 15 : 11–15. [Google Scholar]
  19. Collins WE, Skinner JC, Coifman RF, 1967. Fluorescent antibody studies in human malaria. V. Response of sera from Nigerians to five Plasmodium antigens. Am J Trop Med Hyg 16 : 568–571. [Google Scholar]
  20. Collins WE, Warren McW, Skinner JC, Fredericks HJ, 1968. Studies on the relationship between fluorescent antibody response and ecology of malaria in Malaysia. Bull Wld Hlth Org 39 : 451–463. [Google Scholar]
  21. Meuwissen JHETh, 1968. Fluorescent antibodies in human malaria, especially in Plasmodium ovale. Trop Geogr Med 18 : 250–259. [Google Scholar]
  22. Meuwissen JHETh, 1968. Antibody responses of patients with natural malaria to human and simian Plasmodium antigens measured by the fluorescent antibody test. Trop Geogr Med 20 : 137–140. [Google Scholar]
  23. Mannweiler E, Mohr W, Lang W, Pfannemuller L, zum Felde I, 1977. Identification of plasmodial antibodies in the immunodiagnosis of malaria. Med Klin 72 : 1818–1821. [Google Scholar]
  24. Draper CC, Sirr SS, 1980. Serological investigations in retrospective diagnosis of malaria. BMJ 280 : 1575–1576. [Google Scholar]
  25. Salfeider A, Mannweiler E, 1981. Immunodiagnostic findings in sera of patients with leishmaniasis, Chagas’ disease, malaria and amebiasis in endemic regions of Venezuela. Tropenmed Parasitol 32 : 194–196. [Google Scholar]
  26. Knobloch J, Mannweiler E, zum Feide I, 1982. Determination of malarial antibodies by means of screening and differentiating antigens. Zentr Bakt Mikrobiol Hyg 252 : 566–571. [Google Scholar]
  27. Gebreel AO, Gilles HM, Prescott JE, 1985. Studies on the seroepidemiology of endemic diseases in Libya, IV. Malaria. Ann Trop Med Parasitol 79 : 341–347. [Google Scholar]
  28. Collins WE, Skinner JC, Stanfill PS, Sutton BB, Huong AY, 1984. Infection and transmission studies with the N-3 strain of Plasmodium fieldi in the Macaca mulatta monkey. J Parasitol 70 : 422–427. [Google Scholar]
  29. Collins WE, Guinn E, Held JR, 1966. Studies on the transmission of two strains of Plasmodium inui by Anopheles maculatus and An. stephensi. J Parasitol 52 : 664–668. [Google Scholar]
  30. Earle WC, Perez M, 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17 : 1124–1130. [Google Scholar]
  31. Coggelshall LT, Kumm HW, 1938. Effect of repeated superinfections upon the potency of immune serum of monkeys harboring chronic infections of P. knowlesi. J Exp Med 68 : 17–27. [Google Scholar]
  32. Freund J, Thomson KJ, Sommer HE, Walter AW, Pisani TM, 1948. Immunization of monkeys against malaria by means of killed parasites with adjuvants. Am J Trop Med 28 : 1–22. [Google Scholar]
  33. Puri SK, Dutta GP, 2003. Blood schizontocidal activity of WR238605 (Tafenoquine) against Plasmodium cynomolgi and Plasmodium fragile infections in rhesus monkeys. Acta Trop 86 : 35–40. [Google Scholar]
  34. Bhardwaj D, Kushwaha A, Puri SK, Herrera A, Singh N, Chauhan VS, 2003. DNA prime-protein boost immunization in monkeys: efficacy of a novel construct containing functional domains of Plasmodium cynomolgi CS and TRAP. FEMS Immunol Med Microbiol 39 : 241–250. [Google Scholar]
  35. Shanks GD, Edstein MD, Chedester AL, Smith CD, Corcoran KD, Ngampochjana M, Hansukjariya P, Sattabongkot J, Webster HK, 1994. Proguanil plus sulfamethoxazole is not casually pro-phylactic in the Macaca mulatta-Plasmodium cynomolgi model. Am J Trop Med Hyg 50 : 641–645. [Google Scholar]
  36. Corcoran KD, Hansukjariya P, Sattabongkot J, Ngampochjana M, Edstein MD, Smith CD, Shanks GD, Milhous WK, 1993. Causal prophylactic and radical curative activity of WR182393 (a gua-nylhydrazone) against Plasmodium cynomolgi in Macaca mulatta. Am J Trop Med Hyg 49 : 473–477. [Google Scholar]
  37. Dutta S, Kaushal DC, Ware LA, Puri SK, Kaushal NA, Narula A, Upadhyaya DS, Lanar DE, 2005. Merozoite surface protein 1 of Plasmodium vivax induces a protective response against Plasmodium cynomolgi challenge in rhesus monkeys. Infect Immun 73 : 5936–5944. [Google Scholar]
  38. Trager W, 1966. Coenzyme A and the antimalarial action in vitro of antipantothenate against Plasmodium lophurae, P. coatneyi, and P. falciparum. Trans NY Acad Sci 28 : 1094–1108. [Google Scholar]
  39. MaenoY, Brown AE, Smith CD , Tegoshi T, Toyoshima T, Okenhouse CF, Corcoran KD, Ngampochjana M, Kyle DE, Webster HK, Aikawa M, 1993. A nonhuman primate model for human cerebral malaria: effects of artesunate (quinhaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi. Am J Trop Med Hyg 49 : 726–734. [Google Scholar]
  40. Glew RH, Atkinson JP, Frank MM, Collins WE, Neva FA, 1975. Serum complement and immunity in experimental simian malaria. I. Cyclical alterations in C4 related to schizont rupture. J Infect Dis 131 : 17–25. [Google Scholar]
  41. Kilejian A, Abati A, Trager W, 1977. Plasmodium falciparum and Plasmodium coatneyi: immunogenicity of “knob-like protrusions” on infected erythrocyte membranes. Exp Parasitol 42 : 157–164. [Google Scholar]
  42. Collins WE, Chin W, Skinner JC, 1979. Plasmodium fragile and Macaca mulatta monkeys as a model system for the study of malaria vaccines. Am J Trop Med Hyg 28 : 948–954. [Google Scholar]
  43. Collins WE, Pye D, Webster TL, Vandenberg KL, Schoofs PG, Crether PE, Galland GG, Sulzer AJ, Coppel RL, Marshall V, Sullivan JS, Morris CL, Anders RF, 1994. Immunization and efficacy trial of an apical membrane antigen vaccine against Plasmodium fragile in squirrel monkeys. Am J Trop Med Hyg 51 : 711–719. [Google Scholar]
  44. Collins WE, Sullivan JS, Galland GG, Nace D, Williams A, Williams T, Barnwell JW, 2007. Isolates of Plasmodium inui adapted to Macaca mulatta monkeys and laboratory-reared anopheline mosquitoes for experimental study. J Parasitol 93 : 1061–1069. [Google Scholar]

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  • Received : 12 Jan 2009
  • Accepted : 16 Jan 2009

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