Volume 80, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We enrolled 382 patients at two hospitals in Uganda in a prospective observational study of severe sepsis. Because artemisinins improve survival in murine sepsis models, we performed a analysis of the association between the use of artemether-lumefantrine (A-L) and mortality in patients with or without malaria. In patients with negative malaria smears ( = 328 of 379), Kaplan–Meier curves revealed decreased combined inpatient and 30-day mortality among patients receiving A-L versus those who did not (20.6%, SE = 10.6 versus 48.8%, SE = 3.2; Log rank χ = 3.93, = 0.048). The decrease in mortality associated with A-L was maintained in the most clinically ill patients determined by Karnofsky Performance Scores ≤ 50 (16.7%, SE = 15.2 versus 58.3%, SE = 3.7; Log rank χ 3.94, = 0.041). Research into the properties of A-L is needed to improve treatment of sepsis without compromising malarial susceptibility.


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  • Received : 06 Jun 2008
  • Accepted : 22 Jan 2009

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