Volume 80, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Africa’s populous country, Nigeria, contains or contained more cases of dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis than any other African nation and ranks or ranked first (dracunculiasis, onchocerciasis, schistosomiasis) or third (lymphatic filariasis) in the world for the same diseases. After beginning village-based interventions against dracunculiasis 20 years ago and confronting onchocerciasis a few years later, Nigeria has nearly eliminated dracunculiasis and has provided annual mass drug administration for onchocerciasis to over three quarters of that at-risk population for 7 years. With assistance from The Carter Center, Nigeria began treating lymphatic filariasis and schistosomiasis in two and three states, respectively, over the past decade, while conducting pioneering operational research as a basis for scaling up interventions against those diseases, for which much more remains to be done. This paper describes the status of Nigeria’s struggles against these four neglected tropical diseases and discusses challenges and plans for the future.


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  1. Edungbola LD, Withers PC Jr, Braide EI, Kale OO, Sadiq LO, Nwobi BC, Alakija T, McConnon P, Hopkins DR, 1992. Mobilization strategy for Guinea worm eradication in Nigeria. Am J Trop Med Hyg 47 : 529–538. [Google Scholar]
  2. Jiya JJ, 1998. Problems and perspective in programme management: the case of the National Control Programme in Nigeria. Ann Trop Med Parasitol 92 : S167–S168. [Google Scholar]
  3. Hopkins DR, Eigege A, Miri ES, Gontor I, Ogah G, Umaru J, Gwomkudu CC, Mathai W, Jinadu MY, Amadiegwu S, Oyenekan OK, Korve K, Richards FO, 2002. Lymphatic filariasis elimination and schistosomiasis control in combination with onchocerciasis control in Nigeria. Am J Trop Med Hyg 67 : 266–272. [Google Scholar]
  4. Richards F, Eigege A, Miri E, Jinadu MY, Hopkins DR, 2006. Integration of mass drug administration programs in Nigeria: the challenge of schistosomiasis. Bull World Health Organ 84 : 273–276. [Google Scholar]
  5. Hopkins DR, Ruiz-Tiben E, 1991. Strategies for eradication of dracunculiasis. Bull World Health Organ 69 : 533–540. [Google Scholar]
  6. Edungbola LD, Watts SJ, Kale OO, 1988. The distribution of dracunculiasis in Nigeria: a preliminary study. Int J Epidemiol 17 : 428–433. [Google Scholar]
  7. World Health Organization, 1990. Dracunculiasis: Nigeria. Wkly Epidemiol Rec 65 : 385–387. [Google Scholar]
  8. Watts SJ, 1987. Dracunculiasis in Africa in 1986: its geographic extent, incidence, and at-risk population. Am J Trop Med Hyg 37 : 119–125. [Google Scholar]
  9. Withers PC Jr, 1989. Methodology of the NIGEP Guinea-worm active case search. Nigerian J Parasitol Suppl. No 1 : 39–42. [Google Scholar]
  10. Hopkins DR, Ruiz-Tiben E, Downs P, Withers PC Jr, Roy S, 2008. Dracunculiasis eradication: neglected no longer. Am J Trop Med Hyg 79 : 474–479. [Google Scholar]
  11. Richards FO, Boatin B, Sauerbrey M, Sékétéli A, 2001. Control of onchocerciasis today: status and challenges. Trends Parasitol 17 : 558–563. [Google Scholar]
  12. Richards F, Hopkins D, Cupp E, 2000. Commentary: varying programmatic goals and approaches to river blindness. Lancet 255 : 1663–1664. [Google Scholar]
  13. Abiose A, Murdoch I, Babalola O, Cousens S, Liman I, Onyema J, Evans J, Gregory W, Jones B, 1994. Distribution and aetiology of blindness and visual impairment in meso-endemic onchocercal communities, Kaduna State, Nigeria. Br J Ophthalmol 78 : 8–13. [Google Scholar]
  14. Richards F, Gonzales-Peralta C, Jallah E, Miri E, 1996. Community-based distributors in the delivery of ivemectin: onchocerciasis control at the village level in Plateau State, Nigeria. Acta Trop 61 : 137–144. [Google Scholar]
  15. Gemade EI, Jiya JY, Nwoke BE, Ogunba EO, Edeghere H, Akoh JI, Omojola A, 1998. Human onchocerciasis: current assessment of the disease burden in Nigeria by rapid epidemiological mapping. Ann Trop Med Parasitol 92 : S79–S83. [Google Scholar]
  16. World Health Organization, 2008. African Programme for onchocerciasis control—report on task force meeting, July 2008. Wkly Epidemiol Rec 83 : 307–312. [Google Scholar]
  17. World Health Organization, 1996. Onchocerciasis: Nigeria. Wkly Epidemiol Rec 71 : 213–215. [Google Scholar]
  18. World Health Organization, 1997. River blindness (onchocerciasis): progress in ivermectin distribution, Nigeria. Wkly Epidemiol Rec 72 : 221–228. [Google Scholar]
  19. Miri ES, 1998. Problems and perspectives of managing an onchocerciasis control programme. Ann Trop Med Parasitol 92 : S121–S128. [Google Scholar]
  20. Emukah EC, Osuoha E, Miri ES, Onyenama J, Amazigo U, Obijuru C, Osuji N, Ekeanyanwu J, Amadiegwu S, Korve K, Richards FO, 2004. A longitudinal study of impact of repeated mass ivermectin treatment on clinical manifestations of onchocerciasis in Imo State, Nigeria. Am J Trop Med Hyg 70 : 556–561. [Google Scholar]
  21. Weil GJ, Lammie PJ, Weiss N, 1997. The ICT filariasis test: a rapid-format antigen test for diagnosis of bancroftian filariasis. Parasitol Today 13 : 401–404. [Google Scholar]
  22. Molyneux DH, Neira M, Liese B, Heyman D, 2000. Elimination of lymphatic filariasis as public health problem: setting the scene for elimination. Trans R Soc Trop Med Hyg 94 : 589–591. [Google Scholar]
  23. Ottesen EA, Duke BO, Karam M, Behbehani K, 1997. Strategies and tools for the control/elimination of lymphatic filariasis. Bull World Health Organ 75 : 491–503. [Google Scholar]
  24. World Health Organization, 2007. Global programme to eliminate lymphatic filariasis: progress report on mass drug administration in 2006. Wkly Epidemiol Rec 82 : 361–380. [Google Scholar]
  25. Lindsay SW, Thomas CJ, 2000. Mapping and estimating the population at risk from lymphatic filariasis in Africa. Trans R Soc Trop Med Hyg 94 : 37–45. [Google Scholar]
  26. Richards FO Jr, Pam DD, Kal A, Gerlong GY, Onyeka J, Sambo Y, Danboyi J, Ibrahim B, Terranella A, Kumbak D, Dakul A, Lenhart A, Rakers L, Umaru J, Amadiegwu S, Withers PC Jr, Mafuyai H, Jinadu MY, Miri ES, Eigege A, 2005. Significant decrease in the prevalence of Wuchereria bancrofti infection in anopheline mosquitoes following the addition of albendazole to annual, ivermectin-based, mass treatments in Nigeria. Ann Trop Med Parasitol 99 : 155–164. [Google Scholar]
  27. Chitsulo L, Engels D, Montresor A, Savioli L, 2000. The global status of schistosomiasis and its control. Acta Trop 77 : 41–51. [Google Scholar]
  28. Federal Ministry of Health, 1997. National Plan of Action in Schistosomiasis Control in Nigeria, 1997–2001. Abuja, Nigeria: Federal Ministry of Health.
  29. Gutman J, Fagbemi A, Alphonsus K, Eigege A, Miri ES, Richards FO Jr, 2008. Missed treatment opportunities for Schistosomiasis mansoni in an active urinary treatment program in Plateau and Nasarawa States, Nigeria. Ann Trop Med Parasitol 102 : 335–346. [Google Scholar]
  30. World Health Organization, 1993. The control of schistosomiasis: second report of the WHO expert committee. Geneva: World Health Organization (WHO Technical Report Series No. 830).
  31. Eigege A, Pede E, Miri E, Umaru J, Ogbu Pearce P, Jinadu MY, Njepuome AN, 2008. Triple drug administration (TDA) with praziquantel, ivermectin and albendazole, for the prevention of three neglected tropical diseases in Nigeria. Ann Trop Med Parasitol 102 : 1–3. [Google Scholar]
  32. Hopkins DR, Richards FO, Katabarwa M, 2005. Wither onchocerciasis control in Africa? Am J Trop Med Hyg 72 : 1–2. [Google Scholar]
  33. Centers for Disease Control and Prevention, 1993. Recommendations of the International Task Force for Disease Eradication. MMWR 42 : 10–11. [Google Scholar]
  34. World Health Organization, 2007. Meeting of the International Task Force for Disease Eradication—11 January 2007. Wkly Epidemiol Rec 82 : 197–202. [Google Scholar]
  35. Noor AM, Mutheu JJ, Tatem AJ, Hay SI, Snow RW, 2009. Insecticide-treated net coverage in Africa: mapping progress in 2000–7. Lancet 373 : 58–67. [Google Scholar]
  36. Blackburn BG, Eigege A, Gotau H, Gerlong G, Miri E, Hawley WA, Mathieu E, Richards F, 2006. Successful integration of insecticide-treated bed net distribution with mass drug administration in central Nigeria. Am J Trop Med Hyg 75 : 650–655. [Google Scholar]
  37. Reid M, 2008. Nigeria still searching for right formula. Bull World Health Organ 86 : 663–665. [Google Scholar]
  38. Anonymous, 2008. Community-directed interventions for major health problems in Africa. A multi-country study. Final report. Available at: http://www.who.int/tdr/ir/cdi.htm. Accessed October 24, 2008.
  39. Parker M, Allen T, Hastings J, 2007. Resisting control of neglected tropical diseases: dilemmas in the mass treatment of schistosomiasis and soil-transmitted helminthes in north-west Uganda. J Biosoc Sci 40 : 161–181. [Google Scholar]
  40. Doumenge JP, Mott KE, Chueng C, Villenave D, Perrin MF, Reaud-Thomas G, 1987. Atlas of the Global Distribution of Schistosomiasis. Geneva: World Health Organization.

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  • Received : 14 Nov 2008
  • Accepted : 21 Jan 2009

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