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Volume 80, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

We evaluated the performance of the leishmanin skin test (LST) in 50 patients with visceral leishmaniasis (VL), 124 cured VL patients at different time intervals, 125 healthy controls from an endemic region (HEC), and 14 healthy controls from a non-endemic region (NEHC). The leishmanin antigen used was based on and was obtained from the Pasteur Institute (Iran). A positive LST was found in 14.0% of patients with active VL, 40.3% of cured patients, 21.6% of HECs, and 0% in NEHCs. The 14% positivity in patients with active VL conflicts with the widely held opinion that such patients should be negative because of anergy. Also, a lack of sensitivity of the LST was observed in cured VL patients. An LST antigen produced from strains from India should be explored.

Copyright 2009 The American Society of Tropical Medicine
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/content/journals/10.4269/ajtmh.2009.80.566
2009-04-01
2018-08-14

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References

  1. Carvalho EM, Bacellar O, Barral A, Badaro R, Johnson WD Jr, 1989. Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated. J Clin Invest 83 : 860–864.
  2. Khalil EAG, Ayed NB, Musa AM, Ibrahim ME, Mukhtar MM, Zijlstra EE, Elhassan IM, Smith PG, Kieny PM, Ghalib HW, Zicker F, Modabber F, Elhassan AM, 2005. Dichotomy of protective cellular immune responses to human visceral leishmaniasis. Clin Exp Immunol 140 : 349–353.
  3. Desjeux P, 1992. Human leishmaniasis: epidemiology and public health aspects. World Health Stat Q 45 : 267–275.
  4. Sacks DL, Lal SL, Shrivastava SN, Blackwell JM, Neva FA, 1987. An analysis of T cell responsiveness in Indian Kala-azar. J Immunol 138 : 908–913.
  5. Zijlstra EE, El-Hassan AM, Ismail A, Ghalib HW, 1994. Endemic Kalaazar in eastern Sudan: a longitudinal study of the incidence of clinical and subclinical infection and post kala-azar dermal leishmaniasis. Am J Trop Med Hyg 51 : 826–836.
  6. Antunes CM, Mayrink W, Magalhaes PA, Costa CA, Melo MN, Dias M, Michalick MS, Williams P, Lima AO, Vieira JB, 1986. Controlled field trials of a vaccine against New World cutaneous leishmaniasis. Int J Epidemiol 15 : 572–580.
  7. Khalil EA, El Hassan AM, Zijlstra EE, Mukhtar MM, Ghalib HW, Musa B, Ibrahim ME, Kamil AA, Elsheikh M, Babiker A, Modabber F, 2000. Autoclaved Leishmania major vaccine for prevention of visceral leishmaniasis: a randomized, double-blind, BCG-controlled trial in Sudan. Lancet 356 : 1565–1569.
  8. Momeni AZ, Jalayer T, Emamjomeh M, Khamesipour A, Zicker F, Labaf-Ghasemi R, 1999. A randomized double-blind, controlled trial of killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in Iran. Vaccine 17 : 466–472.
  9. Zhou XH, Obuchowski NA, McClish DK, 2002. Statistical Methods in Diagnostic Medicine. New York: Wiley & Sons.
  10. Sokal JE, 1975. Editorial: Measurement of delayed skin-test responses. N Engl J Med 293 : 501–502.
  11. Manson-Bahr PEC, 1961. Immunity in kala-azar. Trans R Soc Trop Med Hyg 55 : 550–555.
  12. el Safi S, Hamid N, Ahmad-Haleem OA, Hammad A, Kareem HG, Boelaert M, 2004. Infection rates with Leishmania donovani and Mycobacterium tuberculosis in a village in eastern Sudan. Trop Med Int Health 9 : 1305–1311.
  13. Bern C, Amann J, Haque R, Chowdhury AM, Kurkjian KM, Vaz L, Wagatsuma Y, Breiman RF, Secor WE, Maguire JH, 2006. Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral leishmaniasis in Bangladesh. Am J Trop Med Hyg 75 : 744–748.
  14. Mol CJ, Koethe SM, 2006. QuantiFERON TB GOLD: an innovation in tuberculosis screening. Aaohn J 54 : 245–247.
  15. Pai M, Joshi R, Dogra S, Mendiratta DK, Narang P, Dheda K, Kalantri S, 2006. Persistently elevated T cell interferon-gamma responses after treatment for latent tuberculosis infection among health care workers in India: a preliminary report. J Occupat Med Toxicol 1 : 7.
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Evaluation of Leishmanin Skin Test in Indian Visceral Leishmaniasis
The American Journal of Tropical Medicine and Hygiene 80, 566 (2009); https://doi.org/10.4269/ajtmh.2009.80.566
/content/journals/10.4269/ajtmh.2009.80.566
/content/journals/10.4269/ajtmh.2009.80.566
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  • Received : 12 Jun 2008
  • Accepted : 11 Nov 2008

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