1921
Volume 80, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Genetic polymorphisms in are associated with resistance to a number of drugs, but data on their prevalence are limited from many areas. We explored the prevalence of key polymorphisms in patients presenting with malaria in Kinshasa. Prevalences of K76T; N86Y; N51I, C59R, and S108N; and A437G were well above 50% and of Y184F, N1042D, and D1246Y; I164L; and K540E were low. These results suggest an intermediate level of resistance to aminoquinoline and antifolate antimalarials in Kinshasa compared with other areas of Africa.

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2009-04-01
2017-09-23
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  • Received : 31 Oct 2008
  • Accepted : 21 Dec 2008

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