1921
Volume 80, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Malaria preventive strategies in pregnancy were assessed in a health center randomized trial comparing intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) with and without community based promotional activities in rural Burkina Faso. The study involved 2,240 secundigravidae and secundigravidae and evaluated factors associated with antenatal clinic (ANC) attendance and uptake of IPTp-SP. With promotion, 64.2% completed ≥ 3 ANC visits compared with 44.7% without ( = 0.05). Complete uptake of IPTp-SP was 71.8% with and 49.1% without promotion ( = 0.008). The IPTp-SP uptake was lowest in adolescents delivering during high malaria transmission with (29%) or without promotion (30%). Uptake of SP was higher during the low transmission season than in the high transmission season (adjusted odds ratio = 2.17, 95% confidence interval = 1.59–3.03). Community sensitization increased ANC attendance and IPTp-SP uptake. Adolescents were the most difficult to reach, particularly during the high malaria transmission period. The impact of IPTp-SP will be limited unless this high risk group is protected.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2009.80.460
2009-03-01
2017-11-24
Loading full text...

Full text loading...

/deliver/fulltext/14761645/80/3/0800460.html?itemId=/content/journals/10.4269/ajtmh.2009.80.460&mimeType=html&fmt=ahah

References

  1. Steketee RW, Nahlen BL, Parise ME, Menendez C, 2001. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg 64 : 28–35.
  2. Guyatt HL, Snow RW, 2001. The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa. Am J Trop Med Hyg 64 : 36–44.
  3. World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the African Region. AFR/MAL/04/01. Brazzaville, Congo: World Health Organization Regional Office for Africa.
  4. Abou-Zahr CL, Wardlaw TM, 2003. Antenatal Care in Developing Countries—Promises, Achievements and Missed Opportunities. Geneva: World Health Organization and United Nations Children’s Fund.
  5. Parise ME, Ayisi JG, Nahlen BL, Schultz LJ, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW, 1998. Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59 : 813–822.
  6. Shulman CE, Dorman EK, Cutts F, Kawuondo K, Bulmer JN, Peshu N, Marsh K, 1999. Intermittent sulphadoxine-pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet 353 : 632–636.
  7. Verhoeff FH, Brabin BJ, Chimsuku L, Kazembe P, Russell WB, Broadhead RL, 1998. An evaluation of the effects of intermittent sulfadoxine-pyrimethamine treatment in pregnancy on parasite clearance and risk of low birthweight in rural Malawi. Ann Trop Med Parasitol 92 : 141–150.
  8. Crawley J, Hill J, Yartey J, Robalo M, Serufilira A, Ba-Nguz A, Roman E, Palmer A, Asamoa K, Steketee R, 2007. From evidence to action? Challenges to policy change and programme delivery for malaria in pregnancy. Lancet Infect Dis 7 : 145–155.
  9. ter Kuile FO, Steketee RW, 2007. Intermittent preventive therapy with sulfadoxine-pyrimethamine during pregnancy: seeking information on optimal dosing frequency. J Infect Dis 196 : 1574–1576.
  10. World Health Organization, 2005. Global Strategy Plan 2005–2010. Geneva: World Health Organization. Available at: http://www.rollbackmalaria.org/forumV/docs/gsp_en.pdf.
  11. Ministère de la Santé, 2005. Réunion de Consensus National sur le Changement de Politique de Traitement du Paludisme. Ouagadougou, Burkina Faso, 21–23 Février 2005: Programme National de Lutte Contre le Paludisme.
  12. Gikandi PW, Noor AM, Gitonga CW, Ajanga AA, Snow RW, 2008. Access and barriers to measures targeted to prevent malaria in pregnancy in rural Kenya. Trop Med Int Health 13 : 208–217.
  13. Nikiéma B, Haddad S, Potvin L, 2008. Women bargaining to seek healthcare: norms, domestic practices, and implications in rural Burkina Faso. World Dev 36 : 608–624.
  14. Brady M, Saloucou L, Chong E, 2007. Girls’ Adolescence in Burkina Faso—A Pivot Point for Social Change. Ouagadougou, Burkina Faso and New York: The Population Council I: 1–32.
  15. Van Eijk AM, Bles HM, Odhiambo F, Ayisi JG, Blokland IE, Rosen DH, Adazu K, Slutsker L, Lindblade KA, 2006. Use of antenatal services and delivery care among women in rural western Kenya: a community based survey. Reprod Health 3 : 2.
  16. Kiwuwa MS, Mufubenga P, 2008. Use of antenatal care, maternity services, intermittent presumptive treatment and insecticide treated bed nets by pregnant women in Luwero district, Uganda. Malar J 7 : 44.
  17. Brown CA, Sohani SB, Khan K, Lilford R, Mukhwana W, 2008. Antenatal care and perinatal outcomes in Kwale district, Kenya. BMC Pregnancy Childbirth 8 : 2.
  18. Mpembeni RN, Killewo JZ, Leshabari MT, Massawe SN, Jahn A, Mushi D, Mwakipa H, 2007. Use pattern of maternal health services and determinants of skilled care during delivery in Southern Tanzania: implications for achievement of MDG-5 targets. BMC Pregnancy Childbirth 7 : 29.
  19. Van Eijk AM, Ayisi JG, ter Kuile FO, Slutsker L, Otieno JA, Misore AO, Odondi JO, Rosen DH, Kager PA, Steketee RW, Nahlen BL, 2004. Implementation of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in Kisumu, western Kenya. Trop Med Int Health 9 : 630–637.
  20. Hill J, Kazembe P, 2006. Reaching the Abuja target for intermittent preventive treatment of malaria in pregnancy in African women: a review of progress and operational challenges. Trop Med Int Health 11 : 409–418.
  21. Anders K, Marchant T, Chambo P, Mapunda P, Reyburn H, 2008. Timing of intermittent preventive treatment for malaria during pregnancy and the implications of current policy on early uptake in north-east Tanzania. Malar J 7 : 79.
  22. Sirima SB, Cotte AH, Konate A, Moran AC, Asamoa K, Bougouma EC, Diarra A, Ouedraogo A, Parise ME, Newman RD, 2006. Malaria prevention during pregnancy: assessing the disease burden one year after implementing a program of intermittent preventive treatment in Koupela District, Burkina Faso. Am J Trop Med Hyg 75 : 205–211.
  23. Gill CJ, Macleod WB, Mwanakasale V, Chalwe V, Mwananyanda L, Champo D, Mukwamataba D, Chilengi R, Thea DM, Hamer DH, 2007. Inferiority of single-dose sulfadoxine-pyrimethamine intermittent preventive therapy for malaria during pregnancy among HIV-positive Zambian women. J Infect Dis 196 : 1577–1584.
  24. Ministère de la Santé, 2006. Directives Nationales pour la Prise en Charge du Paludisme au Burkina Faso. 1–13. Ouagadougou, Burkina Faso: Programme National de Lutte contre le Paludisme.
  25. Brabin BJ, 1983. An analysis of malaria in pregnancy in Africa. Bull World Health Organ 61 : 1005–1016.
  26. Brady M, Saloucou L, 2007. Addressing the Needs of Married Adolescent Girls in Burkina Faso. Promoting Healthy, Safe, and Productive Transitions to Adulthood. Brief no. 9, 1–4. New York: The Population Council.
  27. Brabin L, Brabin BJ, 2005. HIV, malaria and beyond: reducing the disease burden of female adolescents. Malar J 4 : 2.
  28. World Health Organization, 2007. Adolescent Pregnancy: Unmet Needs and Undone Deeds: A Review of the Literature and Programs. Department of Child and Adolescent Health and Development. Geneva: World Health Organization. Available at: http://www.who.int/child_adolescent_health/documents/discussion/.
  29. Sirima SB, Konate A, Tiono AB, Convelbo N, Cousens S, Pagnoni F, 2003. Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso. Trop Med Int Health 8 : 133–139.
  30. Tiono AB, Kabore Y, Traore A, Convelbo N, Pagnoni F, Sirima SB, 2008. Implementation of home-based management of malaria in children reduces the work load for peripheral health facilities in a rural district of Burkina Faso. Malar J 7 : 201.
  31. Mbonye AK, Magnussen P, Bygbjerg IB, 2007. Intermittent preventive treatment of malaria in pregnancy: the effect of new delivery approaches on access and compliance rates in Uganda. Trop Med Int Health 12 : 519–531.
  32. Msyamboza K, Savage EJ, Kazembe P, Gies S, D’Alessandro U, Brabin BJ, 2009. Community based distribution of sulfadoxine-pyrimethamine for intermittent preventive treatment during pregnancy improved coverage but reduced antenatal attendance in southern Malawi. Trop Med Int Health DOI: 10.1111/j.1365–3156.2008.02197.x.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2009.80.460
Loading
/content/journals/10.4269/ajtmh.2009.80.460
Loading

Data & Media loading...

  • Received : 28 Jul 2008
  • Accepted : 04 Nov 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error