1921
Volume 80, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Cystic echinococosis (CE) is a public health problem caused by . We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6–61.2%) against lung cysts and liver cysts (91.8–100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2009.80.367
2009-03-01
2017-09-26
Loading full text...

Full text loading...

/deliver/fulltext/14761645/80/3/0800367.html?itemId=/content/journals/10.4269/ajtmh.2009.80.367&mimeType=html&fmt=ahah

References

  1. Eckert J, Deplazes P, 2004. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern. Clin Microbiol Rev 17 : 107–135.
  2. Eckert J, Conraths FJ, Tackmann K, 2000. Echinococcosis: an emerging or re-emerging zoonosis? Int J Parasitol 30 : 1283–1294.
  3. Schantz PM, 1991. Parasitic zoonoses in perspective. Int J Parasitol 21 : 161–170.
  4. Dueger EL, Moro PL, Gilman RH, 1999. Oxfendazole treatment of sheep with naturally acquired hydatid disease. Antimicrob Agents Chemother 43 : 2263–2267.
  5. Morris DL, Clarkson MJ, Stallbaumer MF, Pritchard J, Jones RS, Chinnery JB, 1985. Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man. Thorax 40 : 453–458.
  6. Pawlowski ZS, Eckert J, Vuitton DA, Ammann R, Kern P, Craig PS, Dar FK, De Rosa F, Filice C, Gottstein B, Grimm F, Macpherson CN, Sato N, Todorov T, Uchino J, von Sinner W, Wen H, 2001. Echinococcosis in humans: clinical aspects, diagnosis and treatment. Gemmell JE, Mal JR, Roberts MG, Meslin F, Pawlowski Z, eds. WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. Paris: World Health Organization, 20–66.
  7. Thompson R, McManus DP, 2001. Aetiology: parasites and life-cycles. Eckert J, Gemmell MA, Meslin F, Pawlowski Z, eds. WHO/OIE Manual on Echinococcosis in Humans and Animals: A Public Health Problem of Global Concern. Paris: World Health Organization, 1–19.
  8. Pawlowski Z, Eckert J, Vuitton DA, Ammann R, Kem P, Craig PS, Diaz KF, De Rosa F, Filice C, Gottstein B, Grimm F, Macpherson CN, Sato N, Todorov T, Uchino J, von Sinner W, Wen H, 2002. Echinococcosis in humans: clinical aspects, diagnosis and treatment. Eckert J, Gemmell MA, Meslin F, Pawlowski Z, eds. WHO/OIE Manual on Echinococcosis in Humans and Animals: a Public Health Problem of Global Concern. Paris: World Health Organization, 20–71.
  9. Mohamed AE, Yasawy MI, Al Karawi MA, 1998. Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology 45 : 1690–1694.
  10. Horton RJ, 1997. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop 64 : 79–93.
  11. Horton RJ, 1989. Chemotherapy of Echinococcus infection in man with albendazole. Trans R Soc Trop Med Hyg 83 : 97–102.
  12. Marriner SE, Bogan JA, 1981. Pharmacokinetics of oxfendazole in sheep. Am J Vet Res 42 : 1143–1145.
  13. Gonzalez AE, Falcon N, Gavidia C, Garcia HH, Tsang VC, Bernal T, Romero M, Gilman RH, 1997. Treatment of porcine cysticercosis with oxfendazole: a dose-response trial. Vet Rec 141 : 420–422.
  14. Blanton RE, Wachira TM, Zeyhle EE, Njoroge EM, Magambo JK, Schantz PM, 1998. Oxfendazole treatment for cystic hydatid disease in naturally infected animals. Antimicrob Agents Chemother 42 : 601–605.
  15. Stettler M, Fink R, Walker M, Gottstein B, Geary TG, Rossignol JF, Hemphill A, 2003. In vitro parasiticidal effect of nitazoxanide against Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother 47 : 467–474.
  16. Walker M, Rossignol JF, Torgerson P, Hemphill A, 2004. In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes. J Antimicrob Chemother 54 : 609–616.
  17. Moro PL, McDonald J, Gilman RH, Silva B, Verastegui M, Malqui V, Lescano G, Falcon N, Montes G, Bazalar H, 1997. Epidemiology of Echinococcus granulosus infection in the central Peruvian Andes. Bull World Health Organ 75 : 553–561.
  18. Stockis A, De Bruyn S, Gengler C, Rosillon D, 2002. Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d. Int J Clin Pharmacol Ther 40 : 221–227.
  19. Davila-Gutierrez CE, Vasquez C, Trujillo-Hernandez B, Huerta M, 2002. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg 66 : 251–254.
  20. Rossignol JF, Abaza H, Friedman H, 1998. Successful treatment of human fascioliasis with nitazoxanide. Trans R Soc Trop Med Hyg 92 : 103–104.
  21. Soraci AL, Mestorino N, Errecalde JO, 1997. Some pharmaco-kinetic parameters of oxfendazole in sheep. Vet Res Commun 21 : 283–287.
  22. Parashar A, Arya R, 2005. Nitazoxanide. Indian Pediatr 42 : 1161–1165.
  23. Dueger EL, Gilman RH, 2001. Prevalence, intensity, and fertility of ovine cystic echinococcosis in the central Peruvian Andes. Trans R Soc Trop Med Hyg 95 : 379–383.
  24. Himonas C, Antoniadou-Sotiriadou K, Papadopoulos E, 1994. Hydatidosis of food animals in Greece: prevalence of cysts containing viable protoscoleces. J Helminthol 68 : 311–313.
  25. Theodos CM, Griffiths JK, D’Onfro J, Fairfield A, Tzipori S, 1998. Efficacy of nitazoxanide against Cryptosporidium parvum in cell culture and in animal models. Antimicrob Agents Chemother 42 : 1959–1965.
  26. Craig PS, Larrieu E, 2006. Control of cystic echinococcosis/hydatidosis: 1863–2002. Adv Parasitol 61 : 443–508.
  27. Heath D, Yang W, Li T, Xiao Y, Chen X, Huang Y, Yang Y, Wang Q, Qiu J, 2006. Control of hydatidosis. Parasitol Int 55 (Suppl): S247–S252.
  28. Lightowlers MW, Lawrence SB, Gauci CG, Young J, Ralston MJ, Maas D, Health DD, 1996. Vaccination against hydatidosis using a defined recombinant antigen. Parasite Immunol 18 : 457–462.
  29. Lanusse CE, Gascon LH, Prichard RK, 1995. Comparative plasma disposition kinetics of albendazole, fenbendazole, oxfendazole and their metabolites in adult sheep. J Vet Pharmacol Ther 18 : 196–203.
  30. Todorov T, Vutova K, Donev S, Ivanov A, Katzarov K, Takov D, 2005. The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis. Ann Trop Med Parasitol 99 : 649–659.
  31. Urrea-Paris MA, Moreno MJ, Casado N, Rodriguez-Caabeiro F, 2002. Relationship between the efficacy of praziquantel treatment and the cystic differentiation in vivo of Echinococcus granulosus metacestode. Parasitol Res 88 : 26–31.
  32. Teggi A, Lastilla MG, De Rosa F, 1993. Therapy of human hydatid disease with mebendazole and albendazole. Antimicrob Agents Chemother 37 : 1679–1684.
  33. Menezes da Silva A, 2003. Hydatid cyst of the liver-criteria for the selection of appropriate treatment. Acta Trop 85 : 237–242.
  34. Zhang W, Li J, McManus DP, 2003. Concepts in immunology and diagnosis of hydatid disease. Clin Microbiol Rev 16 : 18–36.
  35. Kern P, 2003. Echinococcus granulosus infection: clinical presentation, medical treatment and outcome. Langenbecks Arch Surg 388 : 413–420.
  36. Reinemeyer CR, Courtney CH, 2003. Fármacos contra cestodos y trematodos. Adams HR, ed. Farmacología y Terapéutica Veterinaria. Zaragosa, Spain: Editorial Acribia, 1049–1061.
  37. Hemphill A, Mueller J, Esposito M, 2006. Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert Opin Pharmacother 7 : 953–964.
  38. García JL, Álvarez AI, Redondo PA, Prieto JG, 1997. Estudio de la fertilidad y viabilidad de quistes hidatídicos ovinos. Rev Esp Salud Publica 71 : 445–449.
  39. Moro PL, Bonifacio N, Gilman RH, Lopera L, Silva B, Takumoto R, Verastegui M, Cabrera L, 1999. Field diagnosis of Echinococcus granulosus infection among intermediate and definitive hosts in an endemic focus of human cystic echinococcosis. Trans R Soc Trop Med Hyg 93 : 611–615.
  40. Purriel P, Schantz PM, Beovide H, Mendoza G, 1973. Human echinococcosis (hydatidosis) in Uruguay: a comparison of indices of morbidity and mortality, 1962–71. Bull World Health Organ 49 : 395–402.
  41. Morris DL, Richards KS, Clarkson MJ, Taylor DH, 1990. Comparison of albendazole and praziquantel therapy of Echinococcus granulosus in naturally infected sheep. Vet Parasitol 36 : 83–90.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2009.80.367
Loading
/content/journals/10.4269/ajtmh.2009.80.367
Loading

Data & Media loading...

  • Received : 29 Apr 2008
  • Accepted : 25 Nov 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error