Volume 80, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Cutaneous leishmaniasis caused by () (CL-Lguy) is endemic in the Brazilian Amazon, differing from infection in clinical, diagnostic, and therapeutic aspects. T-cell reactivity to leishmanial antigens possibly involved in the pathogenesis of CL-Lguy was studied herein. Variable lymphoproliferative responses (LPRs) to antigens were found among the 23 studied patients, and 50% of them showed low or no response to these antigens. Active disease was associated with an enrichment of leishmanial-reactive T lymphocytes, mainly TCD4. High and low interferon (IFN)-γ producers were observed. TNF-α, interleukin (IL)-10, and IL-5 were consistently detected. CL-Lguy displayed low antibody response in comparison to patients. CL caused by presented positive LPRs and higher IFN-γ production but undetectable IL-5. seems to induce a down-regulation of the immune system compared with This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy.


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  • Received : 11 Feb 2008
  • Accepted : 20 May 2008

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