Volume 80, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We report two cases of post–kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment of visceral leishmaniasis with miltefosine. Both patients had maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for bodies in a skin snip of lesions. Patients were put on amphotericin B and responded very well for nodular lesions with one course of treatment. However, longer duration of the treatment is needed for total clearance of macular lesions from body surface in PKDL cases. This is the first case report of PKDL in India, which developed after successful treatment of visceral leishmaniasis with miltefosine.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Zijlstra EE, El-Hassan AM, 2001. Leishmaniasis in Sudan: post-kala-azar dermal leishmaniasis. Tran R Soc Trop Med Hyg 95 (Suppl 1): S59–S76.
    [Google Scholar]
  2. Dutta M, Ghosh TK, 1983. Review of current status of leishmaniasis epidemiology, Proceedings of the Indo-UK Workshop on Leishmaniasis, New Delhi: Indian Council of Medical Research: 97–102.
  3. World Health Organization, 1978. A Decade of Health Development in South-east Asia. South-east Asia Regional Publication Series No. 7. New Delhi: World Health Organization.
  4. Ranjan A, Sur D, Singh VP, Siddique NA, Manna B, Lal CS, Sinha PK, Kishore K, Bhattacharya SK, 2005. Risk factors for Indian kala-azar. Am J Trop Med Hyg 73 : 74–78.
    [Google Scholar]
  5. Bhattacharya SK, Sinha PK, Sunder S, Thakur CP, Jha TK, Pandey K, Das VNR, Kumar N, Lal CS, Verma N, Singh VP, Ranjan A, Verma RK, Anders G, Sindermann H, Ganguly NK, 2007. Phase 4 trial of miltefosine for the treatment of Indian visceral leishmaniasis. J Infect Dis 196 : 591–598.
    [Google Scholar]
  6. Sharma MC, Gupta AK, Verma N, Das VN, Saran R, Kar SK, 2000. Demonstration of Leishmania parasites in skin lesions of Indian post kala-azar dermal leishmaniasis (PKDL) cases. J Commun Dis 32 : 67–68.
    [Google Scholar]
  7. Salotra P, Singh R, 2006. Challenges in the diagnosis of post kala-azar dermal leishmaniasis. Indian J Med Res 123 : 295–310.
    [Google Scholar]
  8. Das VNR, Ranjan A, Bimal S, Siddique NA, Pandey K, Kumar N, Verma N, Singh VP, Sinha PK, Bhattacharya SK, 2005. Magnitude of unresponsiveness to sodium stibogluconate in the treatment of visceral leishmaniasis in Bihar. Natl Med J India 18 : 131–133.
    [Google Scholar]
  9. Thakur CP, Narain S, Kumar N, Hasaan SM, Jha DK, Kumar A, 1997. Amphotericin B is superior to sodium antimony glucon-ate in the treatment of Indian post kala-azar dermal leishmaniasis. Ann Trop Med Parasitol 91 : 611–616.
    [Google Scholar]
  • Received : 09 May 2008
  • Accepted : 02 Sep 2008
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error