1921
Volume 80, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Arthritogenicity, as determined by joint swelling and synovial histology, was compared between or within two genospecies that cause Lyme arthritis in humans. The spirochete burden in bladder tissue (a site of spirochete persistence) was documented by quantitative polymerase chain reaction, and immune responses were analyzed. In C3H/HeJ mice, three isolates and two of the three isolates induced severe arthritis and swelling. Previous designation as invasive or noninvasive , or RNA spacer type of did not determine arthritis severity induced by isolates. Compared with the other five isolates, the PBi isolate induced significantly less arthritis, a lower humoral immune response, and persisted at a much lower level in bladder tissue. However, PBi isolates induced similar antigen-specific inflammatory T cell responses from the local draining lymph node. Thus, diverse and isolates were highly arthritogenic in immune competent mice.

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  • Received : 06 Jun 2008
  • Accepted : 06 Oct 2008

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