1921
Volume 80, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A review is presented on studies conducted in New World monkeys and chimpanzees with the Salvador I strain of . This isolate has been adapted to and (squirrel) monkeys and developed as a model for the testing of antimalarial vaccines. After the injection of 10,000 sporozoites, the median prepatent period in monkeys was 21.5 days. In 103 sporozoite-induced infections in splenectomized monkeys, the median maximum parasite count ranged from 2,139 to 202,368/μL, with a median maximum parasite count of 48,174/μL. Median maximum parasite counts in and monkeys were 19,902, 18,390, 21,420, and 18,210/μL, respectively and ranged from 124 to 156,000/μL. Mosquito infections were readily obtained in different species of mosquitoes. The monkey and Salvador I strain seems suitable for the testing of sporozoite and liver stage vaccines but not for blood-stage vaccines against unless adapted further in spleen-intact monkeys.

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2009-02-01
2017-09-24
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  • Received : 22 Sep 2008
  • Accepted : 27 Oct 2008

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