1921
Volume 80, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Duffy binding protein (DBP) is vital for parasite development, thereby making this molecule a good vaccine candidate. Preclinical development of a vaccine often involves use of primate models prior to testing efficacy in humans, but primate isolates are poorly characterized. We analyzed the complete gene coding for the DBP in several isolates that are used for experimental primate infections and compared these sequences with the Salvador I DBP isolate, which is being used for vaccine development. Our results affirm that primate-adapted isolates are genetically similar to circulating in humans, but variability is greatest in the putative target of protective antibodies. In addition, some isolates contain multiple genetically different clones. Testing a DBP vaccine may therefore be complicated by heterogeneity and diversity of the isolates available for challenge.

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2009-02-01
2017-09-20
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  • Received : 09 Sep 2008
  • Accepted : 24 Sep 2008

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