Volume 80, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We compared intralesional glucantine and cryotherapy for treatment of children with cutaneous leishmaniasis in Iran. We observed that cryotherapy is an effective treatment for cutaneous leishmaniasis in children. No serious posttreament side effects were observed in either group. At six months of follow-up, no recurrence of disease was observed in cured patients in either group. Because of its simplicity, lower cost, low rate of serious complications, and greater tolerability, cryotherapy should be recommended as an appropriate alternative treatment for leishmaniasis in children.


Article metrics loading...

Loading full text...

Full text loading...



  1. Talari SA, Talaei R, Shajari GR, Vakili Z, Taghaviardakani A, 2006. Childhood cutaneous leishmaniasis: report of 117 cases from Iran. Korean J Parasitol 44 : 355–360.
  2. Hepburn NC, 2000. Cutaneous leishmaniasis. Clin Exp Dermatol 25 : 363–370.
  3. Khatami A, Firooz A, Gorouhi F, Dowlati Y, 2007. Treatment of acute Old World cutaneous leishmaniasis: a systematic review of the randomized controlled trials. J Am Acad Dermatol 57 : 335.
  4. Palacios R, Osorio LE, Grajales LF, Ochoa MT, 2001. Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonite for cutaneous leishmaniasis due to Leishmania Viannia species. Am J Trop Med Hyg 64 : 187–193.
  5. Cruz A, Rainey PM, Herwaldt BL, Stagni G, Palacios R, Trujillo R, Saravia NG, 2007. Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate. J Infect Dis 195 : 602–608.
  6. Sharifi I, Fekri AR, Aflattonian MR, Nadim A, Nikian Y, Kamesipour A, 1998. Cutaneous leishmaniasis in primary school children in the south-eastern Iranian city of Bam, 1994–95. Bull World Health Organ 76 : 289–293.
  7. Stavropoulos PG, Papakonstantinou AM, Petropoulou H, Kontochristopoulos G, Katsambas A, 2006. Cryotherapy as an adjunct to systemic antimonials for cutaneous leishmaniasis in children. J Eur Acad Dermatol Venereol 20 : 765–766.
  8. Minodier P, Noël G, Blanc P, Uters M, Retornaz K, Garnier JM, 2005. Management of cutaneous leishmaniasis in adults and children. Med Trop 65 : 487–495.
  9. Kafetzis DA, 2003. An overview p of paediatric leishmaniasis. J Postgrad Med 49 : 31–38.
  10. Dowlati Y, 1996. Cutaneous leishmaniasis: clinical aspect. Clin Dermatol 14 : 425–431.
  11. Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Quellette M, 2006. Unresponsiveness to glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med 3 : 0659–0667.
  12. Leibovici V, Homayoun A, 1986. Cryotherapy in acute cutaneous leishmaniasis. Int J Dermatol 25 : 473–475.
  13. Mosleh IM, Geith E, Natshen L, Schonian G, Abotteen N, Kharabsheh S, 2008. Efficacy of a weekly cryotherapy regimen to treat Leishmania major cutaneous leishmaniasis. J Am Acad Dermatol 58 : 617–624.
  14. Asilian A, Sadeghinia A, Faghihi G, Momeni A, Amini Harandi A, 2003. The efficacy of treatment with intralesional meglumine antimoniate alone, compared with that of cryotherapy combined with the meglumine antimoniate or intralesional sodium stibogluconate, in the treatment of cutaneous leishmaniasis. Ann Trop Med Parasitol 97 : 493–498.
  15. Gurei MS, Tatli N, Ozbilge H, Erel O, Seyrek A, Kocyigit A, Ulukanligil M, 2000. Efficacy of crotherapy and intralesional Pentostam in treatment of cutaneous leishmaniasis. J Egypt Soc Parasitol 30 : 169–176.
  16. Leibovici V, Aram H, 1986. Cryotherapy in acute cutaneous leishmaniasis. Int J Dermatol 25 : 473–475.

Data & Media loading...

  • Received : 02 Feb 2008
  • Accepted : 27 Oct 2008

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error