Volume 80, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Information on malaria-associated anemia in adult patients is scarce in South American populations. From 2004 to 2006, malaria patients 18 to 45 years of age were recruited in a descriptive cross-sectional study from two different towns: Manaus, in the Brazilian Amazon (120 patients) where incidence is lower (≈20%), and in Tumaco on the Colombian Pacific Coast (126 patients) where incidence is higher (≈90%). Relationships between hematologic parameters and independent variables were explored using cross-tabulations and multiple linear regression analyses. We found an inverse relationship of hemoglobin (Hb) levels with days of illness in both sites. In Manaus but not in Tumaco, red cell distribution width (RDW) was related to asexual parasitemia. Reticulocytes were higher in infection in Tumaco. Only in Tumaco, two patients with infection presented with severe anemia (Hb < 7 g/dL). Etiologic factors associated with hematologic changes in malaria seem to be multifactorial. More studies are needed to clarify the anemia determinants in uncomplicated malaria in South America, where malaria transmission is mostly unstable.


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  • Received : 25 Aug 2008
  • Accepted : 06 Oct 2008

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