1921
Volume 80, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

We examined 364 school children for intestinal parasites in a sub-urban zone of Caracas, Venezuela. was the most prevalent parasite in stool samples from 34 children. Levels of IgA and IgG antibodies to were assessed by enzyme-linked immunosorbent assay and Western blot before and after treatment with secnidazole. All patients were cured with a reduction of IgA antibody levels in 26 of 34 children and a reduction in IgG-specific antibody levels in 18 of 34 children. Serum of infected patients reacted with proteins of 14 kD to 137 kD. Some patients did not show a change in IgA serum reactivity for parasite proteins by Western blot after treatment. Seventeen children showed reduction of the reactivity or disappearance of protein reactivity (mainly the 14-kD, 122-kD, and 137-kD proteins). Antibody response was not related to clinical status, but quantitative and qualitative serum antibody response against infection could be used to assess levels of new protein markers that decrease or disappear with successful chemotherapy.

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2009-01-01
2017-09-22
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  • Received : 27 Oct 2007
  • Accepted : 25 Jun 2008

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