Volume 80, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


To assess the extents and determinants of long-term CD4 cell increases after initiation of antiretroviral therapy (ART), changes in CD4 cell counts were analyzed in a cohort of HIV-1–infected Senegalese using a mixed-effects model. After a median follow-up of 54 months, an average of 483 CD4 cells/mm (95% confidence interval [CI] = 331; 680) was reached. The average asymptote level was ~421 cells/mm (95% CI = 390; 454) in patients with < 200 cells/mm at baseline and ~500 cells/mm in patients with > 200 cells/mm. The independent predictors of long-term CD4 cell reconstitution were the baseline CD4 cell count and the monthly average viral load over the entire follow-up. This good long-term immune reconstitution, optimal in subjects with low average viral loads and > 200 CD4 cells/mm at baseline, argues in favor of the earliest possible access to ART and underlines the importance of strict compliance with the treatment.


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  • Received : 13 Sep 2007
  • Accepted : 29 Dec 2008

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