1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 81, Issue 5
  4. Article
Volume 81, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

An otherwise healthy 20-year-old woman in Goa, India, received antibiotics after a diagnosis of upper respiratory tract infection. One week later, vivax malaria was diagnosed at a health center, but the patient developed respiratory distress and lost consciousness. She arrived at emergency department in shock, breathless, and comatose. She died within minutes. Two independent laboratories later confirmed by microscopy (140,000/μL) and by nested and real-time polymerase chain reaction methods. Post-mortem examination showed congestion of alveolar capillaries by heavy monocytic infiltrates, along with diffuse damage to alveolar membranes consistent with acute respiratory distress syndrome. Parasites seen in lung tissue were roughly proportionate to both peripheral hyperparasitemia and those seen in other organs without lesions. In this patient, vivax malaria caused a rapidly fatal respiratory distress.

Copyright 2009 The American Society of Tropical Medicine
Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2009.09-0348
2009-11-01
2019-11-21

  • From This Site

    /content/journals/10.4269/ajtmh.2009.09-0348
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/81/5/0810758.html?itemId=/content/journals/10.4269/ajtmh.2009.09-0348&mimeType=html&fmt=ahah

References

  1. Price RN, Tjitra E, Guerra CA, Yeung S, White NJ, Anstey NM, 2007. Vivax malaria: neglected and not benign. Am J Trop Med Hyg 77: 79–87. [Google Scholar]
  2. Mendis K, Sina BJ, Marchesini P, Carter R, 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64: 97–106. [Google Scholar]
  3. Grassi B, Feletti R, 1890. Parasites malariques chez les oiseaux. Arch Ital del Biologie 13: 297–300. [Google Scholar]
  4. Lomar AV, Vidal JE, Lomar FP, Barbas CV, Matos GJ, Boulos M, 2005. Acute respiratory distress syndrome due to vivax malaria: case report and literature review. Braz J Infect Dis 9: 425–430. [Google Scholar]
  5. Kotwal RS, Wenzel RB, Sterling RA, Porter WD, Jordan NN, Petruccelli BP, 2005. An outbreak of malaria in USArmy Rangers returning from Afghanistan. JAMA 293: 212–215. [Google Scholar]
  6. Maguire JD, Fenton ME, Susanti AI, Walker JB, 2007. Plasmodium vivax-associated acute respiratory distress syndrome after extended travel in Afghanistan. Travel Med Infect Dis 5: 301–305. [Google Scholar]
  7. Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A, 2005. Plasmodium vivax malaria. Emerg Infect Dis 11: 132–134. [Google Scholar]
  8. Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S, Kochar A, Khatri MP, Gupta V, 2009. Severe Plasmodium vivax: a report on serial cases from Bikaner in northwestern India. Am J Trop Med Hyg 80: 194–198. [Google Scholar]
  9. Barcus MJ, Basri H, Picarima H, Manyakori C, Sekartuti, Elyazar I, Bangs MJ, Maguire JD, and Baird JK, 2007. Demographic risk factors for severe and fatal vivax and falciparum malaria among hospital admissions in northeastern Indonesian Papua. Am J Trop Med Hyg 77: 984–991. [Google Scholar]
  10. Tjitra E, Anstey NM, Sugiarto P, Warikar N, Kenangalem E, Karyana M, Lampah DA, Price RN, 2008. Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med 5: 890–898. [Google Scholar]
  11. Genton B, Dácremont V, Rare L, Baea K, Reeder JC, Alpers MP, Mueller I, 2008. Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea. PLoS Med 5: e127. [Google Scholar]
  12. Baird JK, 2007. Neglect of Plasmodium vivax malaria. Trends Parasitol 23: 533–539. [Google Scholar]
  13. Anstey NM, Russell B, Yeo TW, Price RN, 2009. The pathophysiology of vivax malaria. Trends Parasitol 25: 220–227. [Google Scholar]
  14. Shaha KK, Mohanthy S, 2006. Alleged dowry death: a study of homicidal burns. Med Sci Law 46: 105–110. [Google Scholar]
  15. Ng OT, Ooi EE, Lee CC, Lee PJ, Ng LC, Pei SW, Tu TM, Loh JP, Leo YS, 2008. Naturally acquired human Plasmodium knowlesi infection, Singapore. Emerg Infect Dis 14: 814–816. [Google Scholar]
  16. Mangold KA, Manson RU, Koay ES, Stephens L, Regner M, Thomson RB Jr, Peterson LR, Kaul KL, 2005. Real-time PCR for detection and identification of Plasmodium spp. J Clin Microbiol 43: 2435–2440. [Google Scholar]
  17. Kimura M, Kaneko O, Liu Q, 1997. Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene. Parasitol Int 46: 91–95. [Google Scholar]
  18. Tan LK, Yacoub S, Scott S, Bhagani S, Jacobs M, 2008. Acute lung injury and other serious complications of Plasmodium vivax malaria. Lancet Infect Dis 8: 449–455. [Google Scholar]
  19. Ewing J, 1902. Contribution to the pathological anatomy of malaria fever. J Exp Med 6: 119–180. [Google Scholar]
  20. Anstey NM, Handojo T, Pain MCF, Kenangalem E, Tjitra E, Price RN, Maguire GP, 2007. Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation. J Infect Dis 195: 589–596. [Google Scholar]
  21. Anstey NM, Jacups SP, Cain T, Pearson T, Ziesing PJ, Fisher DA, Currie BJ, Marks PJ, Maguire GP, 2002. Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity. J Infect Dis 185: 1326–1334. [Google Scholar]
  22. Silamut K, Phu NH, Whitty C, Turner GD, Louwrier K, Mai NT, Simpson JA, Hien TT, White NJ, 1999. A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain. Am J Pathol 155: 395–410. [Google Scholar]
  23. LeClerc Y, Verreault J, Bisson G, 1989. Diffuse lung uptake of tech-netium-99m sulfur colloid in malaria. J Nucl Med 30: 117–119. [Google Scholar]
  24. Pukrittayakamee S, Imwong M, Singhasivanon P, Stepniewska K, Day NJ, White NJ, 2008. Effects of antimalarial drugs on gametocyte carriage in P. vivax. Am J Trop Med Hyg 79: 378–384. [Google Scholar]
  25. Oh MD, Shin H, Shin D, Kim U, Lee S, Kim N, Cho MH, Chai JY, Choe K, 2001. Clinical features of vivax malaria. Am J Trop Med Hyg 65: 143–146. [Google Scholar]
  26. McKenzie FE, Jeffery GM, Collins WE, 2002. Plasmodium vivax blood-stage dynamics. J Parasitol 88: 521–535. [Google Scholar]
  27. Karunaweera ND, Carter R, Grau GE, Mendis KN, 1998. Demonstration of anti-disease immunity to Plasmodium vivax malaria in Sri Lanka using a quantitative method to assess clinical disease. Am J Trop Med Hyg 58: 204–210. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2009.09-0348
Loading
Histopathology of Fatal Respiratory Distress Caused by Plasmodium vivax Malaria
The American Journal of Tropical Medicine and Hygiene 81, 758 (2009); https://doi.org/10.4269/ajtmh.2009.09-0348
/content/journals/10.4269/ajtmh.2009.09-0348
/content/journals/10.4269/ajtmh.2009.09-0348
Loading

Data & Media loading...

  • Received : 22 Jun 2009
  • Accepted : 30 Jul 2009

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error