1921
Volume 81, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Yunnan Province of China is considered the site of origin for modern plague. We analyzed the genotypes of eight strains isolated from three counties in Yunnan Province by pulse field gel electrophoresis (PFGE). PFGE showed that strains isolated from the same site were identical regardless of hosts or year of isolation. However, strains isolated from geographically distinct loci were genetically divergent. Whole genome sequences of two strains from two foci in Yunnan showed that the genetic variation of strains was caused by genome rearrangement. We concluded that strains in each epidemic focus in Yunnan were a clonal population and selected by host environments. The genomic variability of the strains from different foci were caused by genome rearrangement, which may provide a positive selective advantage for to adapt to its host environments.

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2017-11-19
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  • Received : 03 Apr 2009
  • Accepted : 14 Jul 2009

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